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Cited by 381

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

Biological and clinical significance of DNA damage in the male germ line

Open access
Aitken, R. John, De Iuliis, Geoffry N., McLachlan, Robert I.·2009·International Journal of Andrology
DOI 10.1111/j.1365-2605.2008.00943.x
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Abstract

Summary: DNA damage is a common feature of human spermatozoa with purported links to poor rates of conception, impaired embryonic development, an increased incidence of miscarriage and the appearance of various kinds of morbidity in the offspring including childhood cancer. However, difficulties in interpretation arise, because these associations are not consistently observed across all data sets. Such inconsistency reflects the inherent complexity of the reproductive process, large variations in sample size, differences in patient selection, inadequate study design as well as inter‐individual differences in the type of DNA damage being detected and the effectiveness of repair mechanisms in the oocyte. This review considers the type, source and measurement of DNA damage in human spermatozoa. It also addresses the clinical utility of the information generated in such studies, and highlights areas where further research is needed to bridge the gap between an intriguing biological phenomenon and the evidence‐based clinical management of male patients characterized by high levels of DNA damage in their spermatozoa.

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Citations

Cites

Show all 77 references

Research works printed but not linked: 19

  1. 10.1159/000077501 · doi:10.1159/000077501
  2. 10.1093/humrep/del351 · doi:10.1093/humrep/del351
  3. 10.1111/j.1365-2605.1989.tb01290.x · doi:10.1111/j.1365-2605.1989.tb01290.x
  4. 10.1586/17474108.3.3.267 · doi:10.1586/17474108.3.3.267
  5. ASRM Practice Committee, 2006, The clinical utility of sperm DNA integrity testing, Fertility and Sterility, 86, S35
  6. Caglar G. S., 2007, Semen DNA fragmentation index, evaluated with both TUNEL and Comet assay, and the ICSI outcome, In Vivo, 21, 1075
  7. 10.1093/humrep/dem002 · doi:10.1093/humrep/dem002
  8. 10.1071/RD05065 · doi:10.1071/rd05065
  9. 10.1093/humrep/dei082 · doi:10.1093/humrep/dei082
  10. 10.1093/humrep/deh417 · DOI
  11. 10.1111/j.1365-2605.2001.0317a.x · doi:10.1111/j.1365-2605.2001.0317a.x
  12. Karydis S., 2005, ICSI outcome is not associated with the incidence of spermatozoa with abnormal chromatin condensation, In Vivo, 19, 921
  13. 10.1016/j.annepidem.2003.10.003 · doi:10.1016/j.annepidem.2003.10.003
  14. 10.1016/S1472-6483(10)61776-2 · doi:10.1016/s1472-6483(10)61776-2
  15. 10.1016/j.taap.2004.06.028 · doi:10.1016/j.taap.2004.06.028
  16. 10.1016/j.mrfmmm.2007.05.012 · DOI
  17. 10.1093/humrep/deg259 · doi:10.1093/humrep/deg259
  18. Sega G. A., 1991, Adducts in sperm protamine and DNA vs. mutation frequency, Progress in Clinical and Biological Research, 372, 521
  19. 10.1016/j.mrfmmm.2006.01.017 · doi:10.1016/j.mrfmmm.2006.01.017

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Metadata

Authors
Aitken, R. J., De Iuliis, G. N., & McLachlan, R. I.
Venue
International Journal of Andrology
Publisher
Wiley
Published
2009-01-05
Volume
32
Issue
1
Pages
46-56
ISSN
  • 0105-6263 (ISSN-L)
  • 1365-2605
DOI
10.1111/j.1365-2605.2008.00943.x
OpenAlex
W2123490472
Cited by
381
References
77
FWCI
29.20
Type
journal article
Language
en
Open access
bronze
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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CoChat. (2026). Citation check: Biological and clinical significance of DNA damage in the male germ line. https://app.cochat.ai/papers/10.1111/j.1365-2605.2008.00943.x
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Aitken, R. J., De Iuliis, G. N., & McLachlan, R. I. (2009). Biological and clinical significance of DNA damage in the male germ line. International Journal of Andrology. https://doi.org/10.1111/j.1365-2605.2008.00943.x

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.