Cited by 379Bacterial biofilms and quorum sensingGut microbiota and healthOral microbiology and periodontitis research

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Microbial biofilms in the human gastrointestinal tract

Macfarlane, S., Dillon, J.F.·2007·Journal of Applied Microbiology

DOI 10.1111/j.1365-2672.2007.03287.x

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Abstract

The human gastrointestinal tract contains rich and diverse microbiotas along its length. However, while extensive studies have been made on lumenal bacterial communities in the gut, less work has been carried out on organisms growing in biofilms, where individual groups of bacteria exist in a multiplicity of different microhabitats and metabolic niches associated with the mucosa, the mucus layer and particulate surfaces in the gut lumen. Bacteria and yeasts also occur in biofilms attached to artificial surfaces and devices implanted in the host, such as in patients being fed via enteral tubes. Although we are just beginning to investigate the composition and metabolic activities of these structures, increasing evidence suggests that they are important to the host in both health and disease. There is mounting interest in mucosal biofilms in the colon, especially with respect to their role in inflammatory bowel disease. Because bacteria growing in biofilms are more resistant to antibiotics than unattached organisms, it is often difficult to modify the structure and composition of these communities, or to eradicate them from the body. However, recent work has shown that there is considerable potential to alter the species composition of mucosal biofilms in a beneficial way using synbiotics.

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“Moreover, the brain modulates myriad gut functions that includes mucosal immune response; secretion of acids, bicarbonates, and mucus; and gastric motility (Macfarlane and Dillon, 2007).”
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Isolation and Purification of Sulfate-Reducing Bacteria
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Synergistic interactions prevail in multispecies biofilms formed by the human gut microbiota on mucin
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Method
Mining the human gut microbiome for novel stress resistance genes
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Enterocyte-Associated Microbiome of the Hadza Hunter-Gatherers
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“interventional strategies infections (Donlan, 2001; Steward and Costeron, 2001; Gilbert et al., 2002; Stoodley et al., 2004; Lasa et al., 2005; Sanclement et al., 2005; Macfarlane and Dillon, 2007; Vlastarakos et al., 2007; Macedo and Abraham, 2009; Wolcott and Ehrlich, 2008; Coenye and Nelis, 2010; Drago et al., 2012…”
Background
Gut power: Modulation of human amyloid formation by amyloidogenic proteins in the gastrointestinal tract
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Bioinspired in vitro intestinal mucus model for 3D-dynamic culture of bacteria
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“This dynamics influences the bacterial gene expression, adhesion to substrate and molecules production [12], resulting, at the macroscopic scale, in changes in growth rate, clearance [13] and intestinal biofilm formation [14].”

Authors: Macfarlane, S., & Dillon, J. F.
Affiliations: University of Dundee (GB)
Corresponding author: Macfarlane, S.
ORCID: Macfarlane, S.
Dillon, J.F.
Venue: Journal of Applied Microbiology
Publisher: Oxford University Press (OUP)
Published: 2007-05
Volume: 102
Issue: 5
Pages: 1187-1196
ISSN: 1364-5072 (ISSN-L)
1365-2672
DOI: 10.1111/j.1365-2672.2007.03287.x
OpenAlex: W2041418306
Cited by: 379
References: 55
Citations by year: 2026: 11 · 2025: 10 · 2024: 20 · 2023: 26 · 2022: 24 · 2021: 25 · 2020: 28 · 2019: 31 · 2018: 22 · 2017: 26 · 2016: 14 · 2015: 17 · 2014: 32 · 2013: 16 · 2012: 20
FWCI: 0.98
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3045 d)
Locations: Journal of Applied Microbiology (publishedVersion)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: biofilm, gastrointestinal tract, gut microbiota, mucus layer, inflammatory bowel disease, antibiotic resistance, synbiotics
MeSH terms: Bacteria, Humans, Intestinal Mucosa, Biofilms, Probiotics, Gastrointestinal Tract

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Microbial biofilms in the human gastrointestinal tract

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