Synbiotic therapy ( Bifidobacterium longum /Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial
Open accessAbstract
Background and aims: Ulcerative colitis (UC) is an acute and chronic inflammatory disease of the large bowel with unknown aetiology. The immune response against normal commensal microorganisms is believed to drive inflammatory processes associated with UC. Therefore, modulation of bacterial communities on the gut mucosa, through the use of probiotics and prebiotics, may be used to modify the disease state. Methods: A synbiotic was developed for use in UC patients combining a probiotic, Bifidobacterium longum , isolated from healthy rectal epithelium, and a prebiotic (Synergy 1), a preferential inulin-oligofructose growth substrate for the probiotic strain. Treatment was employed in a double blinded randomised controlled trial using 18 patients with active UC for a period of one month. Clinical status was scored and rectal biopsies were collected before and after treatment, and transcription levels of epithelium related immune markers were measured. Results: Sigmoidoscopy scores (scale 0–6) were reduced in the test group (start 4.5 (1.4), end 3.1 (2.5)) compared with placebo (start 2.6 (2.1), end 3.2 (2.2)) (p = 0.06). mRNA levels for human beta defensins 2, 3, and 4, which are strongly upregulated in active UC, were significantly reduced in the test group after treatment (p = 0.016, 0.038, and 0.008, respectively). Tumour necrosis factor α and interleukin 1α, which are inflammatory cytokines that drive inflammation and induce defensin expression, were also significantly reduced after treatment (p = 0.018 and 0.023, respectively). Biopsies in the test group had reduced inflammation and regeneration of epithelial tissue. Conclusions: Short term synbiotic treatment of active UC resulted in improvement of the full clinical appearance of chronic inflammation in patients receiving this therapy.
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Cites
Biostatistics: A Foundation for Analysis in the Health Sciences.
Rosenfeld, B., & Daniel, W. W. (1984) · Journal of the American Statistical Association · doi:10.2307/2288760 · Cited by 2,841 · see citing works
Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
Butcher, E. C. (1991) · Cell · doi:10.1016/0092-8674(91)90279-8 · Cited by 2,789 · see citing works
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554 · see citing works
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C., & Horak, I. D. (1993) · Cell · doi:10.1016/0092-8674(93)80067-o · Cited by 1,744 · see citing works
A simple clinical colitis activity index
Walmsley, R. S., Ayres, R., Pounder, R. E., & Allan, R. N. (1998) · Gut · doi:10.1136/gut.43.1.29 · Cited by 1,320 · see citing works
Taurog, J. D., Richardson, J. A., Croft, J. T., Simmons, W. A., Zhou, M., FERNÁNDEZ-SUEIRO, J. L., Balish, E., & Hammer, R. E. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2359 · Cited by 1,156 · see citing works
Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial
Gionchetti, P., Rizzello, F., Helwig, U., Venturi, A., Lammers, K. M., Brigidi, P., Vitali, B., Poggioli, G., Miglioli, M., & Campieri, M. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00171-9 · Cited by 1,147 · see citing works
Rembacken, B., Snelling, A. M., Hawkey, P. M., Chalmers, D. M., & Axon, A. (1999) · The Lancet · doi:10.1016/s0140-6736(98)06343-0 · Cited by 1,100 · see citing works
Duchmann, R., Kaiser, I., Hermann, E., Mayet, W.-J., Ewe, K., & BÜSCHENFELDE, K.-H. M. Z. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb03836.x · Cited by 938 · see citing works
Mimura, T., Rizzello, F., Helwig, U., Poggioli, G., Schreiber, S., Talbot, I. C., Nicholls, R. J., Gionchetti, P., Campieri, M., & Kamm, M. A. (2003) · Gut · doi:10.1136/gut.53.1.108 · Cited by 912 · see citing works
Kruis, W., SCHÜTZ, E., Fric, P., Fixa, B., Judmaier, G., & Stolte, M. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1997.00225.x · Cited by 774 · see citing works
Saccharomyces boulardii in Maintenance Treatment of Crohn’s Disease
Guslandi, M., Mezzi, G., Sorghi, M., & Testoni, P. A. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005588911207 · Cited by 722 · see citing works
Biostatistics: A Foundation for Analysis in the Health Sciences.
Daniel, W. W. (1988) · Biometrics · doi:10.2307/2531929 · Cited by 621 · see citing works
Variation Between Observers in Describing Mucosal Appearances in Proctocolitis
Baron, J. H., Connell, A. M., & Lennard-Jones, J. E. (1964) · BMJ · doi:10.1136/bmj.1.5375.89 · Cited by 614 · see citing works
Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium.
O′Neil, D. A., Porter, E. M., Elewaut, D. S., Anderson, G. M., Eckmann, L., Ganz, T., & Kagnoff, M. F. (1999) · PubMed · Cited by 596 · see citing works
Self-citationVenturi, Gionchetti, P., Rizzello, F., Johansson, Zucconi, Brigidi, P., Matteuzzi, & Campieri, M. (1999) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1999.00560.x · Cited by 567 · see citing works
Widespread expression of beta‐defensin hBD‐1 in human secretory glands and epithelial cells
Zhao, C., Wang, I., & Lehrer, R. I. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)01123-4 · Cited by 554 · see citing works
Prebiotics and synbiotics: concepts and nutritional properties
Roberfroid, M. B. (1998) · British Journal Of Nutrition · doi:10.1017/s0007114500006024 · Cited by 347 · see citing works
Borruel, N., Carol, M., Casellas, F., Antolı́n, M., de Lara, F., Espín, E., Naval, J., Guarner, F., & Malagelada, J. (2002) · Gut · doi:10.1136/gut.51.5.659 · Cited by 326 · see citing works
Schultsz, C., van den Berg, F. M., ten Kate, F. J. W., Tytgat, G. N. J., & Dankert, J. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70393-8 · Cited by 311 · see citing works
Wehkamp, J., Harder, J., Weichenthal, M., Mueller, O., Herrlinger, K. R., Fellermann, K., Schroeder, J. M., & Stange, E. F. (2003) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200307000-00001 · Cited by 295 · see citing works
The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria
Stagg, A. J., Hart, A. L., Knight, S. C., & Kamm, M. A. (2003) · Gut · doi:10.1136/gut.52.10.1522 · Cited by 231 · see citing works
Turunen, U., Färkkilä, M. A., HAKALA, K., Seppälä, K., Sivonen, K., OGREN, M., Vuoristo, M., Valtonen, V., & Miettinen, T. A. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70076-9 · Cited by 229 · see citing works
Identification of Multiple Novel Epididymis-Specific β-Defensin Isoforms in Humans and Mice
Yamaguchi, Y., Nagase, T., Makita, R., Fukuhara, S., Tomita, T., Tominaga, T., Kurihara, H., & Ouchi, Y. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2516 · Cited by 228 · see citing works
Bacteria as the cause of ulcerative colitis
Campieri, M., & Gionchetti, P. (2001) · Gut · doi:10.1136/gut.48.1.132 · Cited by 215 · see citing works
Recent Developments in the Immunology of Inflammatory Bowel Disease
MacDonald, Monteleone, & Pender (2000) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2000.00658.x · Cited by 197 · see citing works
Probiotics, infection and immunity
Macfarlane, G. T., & Cummings, J. H. (2002) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200210000-00008 · Cited by 185 · see citing works
Self-citationDickinson, R., O'Connor, H. J., Pinder, I. F., Hamilton, I., Johnston, D., & Axon, A. T. R. (1985) · Gut · doi:10.1136/gut.26.12.1380 · Cited by 184 · see citing works
Mantzaris, G. J., Hatzis, A., Kontogiannis, P., & Triadaphyllou, G. (1994) · PubMed · Cited by 171 · see citing works
Macfarlane, S., Furrie, E., Cummings, J. H., & Macfarlane, G. T. (2004) · Clinical Infectious Diseases · doi:10.1086/420823 · Cited by 167 · see citing works
Self-citationA study of fructo oligosaccharides in the prevention of travellers’ diarrhoea
Cummings, J. H., Christie, S., & Cole, T. J. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.01043.x · Cited by 164 · see citing works
Self-citationFellermann, K., Wehkamp, J., Herrlinger, K. R., & Stange, E. F. (2003) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200306000-00008 · Cited by 148 · see citing works
Matsuda, H., Fujiyama, Y., Andoh, A., Ushijima, T., Kajinami, T., & Bamba, T. (2000) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2000.02045.x · Cited by 133 · see citing works
O′Neil, D. A., Cole, S. P., Martin-Porter, E., Housley, M. P., Liu, L., Ganz, T., & Kagnoff, M. F. (2000) · Infection and Immunity · doi:10.1128/iai.68.9.5412-5415.2000 · Cited by 118 · see citing works
Self-citationMucosa-associated bacterial flora of the human colon
Poxton, I. R., Brown, R. L., Sawyerr, A. M., & Ferguson, A. (1997) · Journal of Medical Microbiology · doi:10.1099/00222615-46-1-85 · Cited by 114 · see citing works
Daig, R., Rogler, G., Aschenbrenner, E., Vogl, D., Falk, W., Gross, V., Schölmerich, J., & Andus, T. (2000) · Gut · doi:10.1136/gut.46.3.350 · Cited by 104 · see citing works
Use of Probiotics in the Treatment of Inflammatory Bowel Disease
Hart, A. L., Stagg, A. J., & Kamm, M. A. (2003) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200302000-00005 · Cited by 102 · see citing works
The rectal mucosa-associated microflora in patients with ulcerative colitis
Hartley, M. G., HUDSON, M. J., Swarbrick, E. T., Hill, M. J., Gent, A. E., Hellier, M. D., & Grace, R. H. (1992) · Journal of Medical Microbiology · doi:10.1099/00222615-36-2-96 · Cited by 80 · see citing works
Mucosal cytokine expression, cellular markers and adhesion molecules in inflammatory bowel disease
Woywodt, A., Ludwig, D., Neustock, P., et al. (1999) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199903000-00010 · Cited by 79 · see citing works
Laake, K., Line, P., Aabakken, L., Løtveit, T., Bakka, A. O., Eide, J., Rosetti, A., Grzyb, K., BJØRNEKLETT, A., & Vatn, M. H. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310000906 · Cited by 64 · see citing works
Regulation of expression of β-defensins: endogenous enteric peptide antibiotics
O′Neil, D. A. (2003) · Molecular Immunology · doi:10.1016/s0161-5890(03)00161-5 · Cited by 51 · see citing works
Self-citationCiprofloxacin as a treatment for ulcerative colitis—not yet
Present, D. H. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70104-0 · Cited by 26 · see citing works
Challenges In Inflammatory Bowel Disease
Windsor, A. C. J. (2002) · Colorectal Disease · doi:10.1046/j.1463-1318.2002.00365.x · Cited by 19 · see citing works
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Dominant and diet-responsive groups of bacteria within the human colonic microbiota
Walker, A. W., Ince, J., Duncan, S. H., Webster, L. M., Holtrop, G., Ze, X., Brown, D., Stares, M. D., Scott, P., Bergerat, A., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2010.118 · Cited by 1,632 · see citing works
The influence of diet on the gut microbiota
Scott, K. P., Gratz, S. W., Sheridan, P. O., Flint, H. J., & Duncan, S. H. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.020 · Cited by 1,052 · see citing works
Belenguer, A., Duncan, S. H., Calder, A. G., Holtrop, G., Louis, P., Lobley, G. E., & Flint, H. J. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.5.3593-3599.2006 · Cited by 856 · see citing works
The gut microbiota and inflammatory bowel disease
Matsuoka, K., & Kanai, T. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-014-0454-4 · Cited by 804 · see citing works
Khan, I., Ullah, N., Zha, L., Bai, Y., Khan, A., Zhao, T., Che, T., & Zhang, C. (2019) · Pathogens · doi:10.3390/pathogens8030126 · Cited by 771 · see citing works
Beneficial effects of probiotic consumption on the immune system
Maldonado Galdeano, C., Cazorla, S. I., Lemme Dumit, J. M., Vélez, E., & Perdigón, G. (2019) · Annals of Nutrition and Metabolism · doi:10.1159/000496426 · Cited by 729 · see citing works
Inflammatory bowel diseases (IBD) and the microbiome-searching the crime scene for clues
Lee, M., & Chang, E. B. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.09.056 · Cited by 645 · see citing works
Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits
PICARD, C., FIORAMONTI, J., FRANCOIS, A., ROBINSON, T., NEANT, F., & MATUCHANSKY, C. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02615.x · Cited by 618 · see citing works
Miele, E., Pascarella, F., Giannetti, E., Quaglietta, L., Baldassano, R. N., & Staiano, A. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.118 · Cited by 517 · see citing works
Role of Probiotics in Human Gut Microbiome-Associated Diseases
Kim, S.-K., Guevarra, R. B., Kim, Y.-T., Kwon, J., Kim, H., Cho, J. H., Kim, H. B., & Lee, J.-H. (2019) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1906.06064 · Cited by 519 · see citing works
Sood, A., Midha, V., Makharia, G. K., Ahuja, V., Singal, D., Goswami, P., & Tandon, R. K. (2009) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2009.07.016 · Cited by 513 · see citing works
<i><i>Bifidobacterium infantis</i></i>35624 modulates host inflammatory processes beyond the gut
Groeger, D., O’Mahony, L., Murphy, E. F., Bourke, J. F., Dinan, T. G., Kiely, B., Shanahan, F., & Quigley, E. M. M. (2013) · Gut Microbes · doi:10.4161/gmic.25487 · Cited by 448 · see citing works
Probiotics, prebiotics and amelioration of diseases
Tsai, Y.-L., Lin, T.-L., Chang, C.-J., Wu, T.-R., Lai, W.-F., Lu, C.-C., & Lai, H.-C. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-018-0493-6 · Cited by 388 · see citing works
Microbial biofilms in the human gastrointestinal tract
Macfarlane, S., & Dillon, J. F. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03287.x · Cited by 379 · see citing works
Self-citationShen, J., Zuo, Z.-X., & Mao, A.-P. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000437495.30052.be · Cited by 364 · see citing works
Emergent Sources of Prebiotics: Seaweeds and Microalgae
De Jesus Raposo, M., De Morais, A., & De Morais, R. (2016) · Marine Drugs · doi:10.3390/md14020027 · Cited by 331 · see citing works
Ganji‐Arjenaki, M., & Rafieian‐Kopaei, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25911 · Cited by 314 · see citing works
International Society of Sports Nutrition Position Stand: Probiotics
Jäger, R., Mohr, A. E., Carpenter, K. C., Kerksick, C. M., Purpura, M., Moussa, A., Townsend, J. R., Lamprecht, M., West, N. P., Black, K., et al. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0329-0 · Cited by 277 · see citing works
Prebiotics, immune function, infection and inflammation: a review of the evidence
Lomax, A. R., & Calder, P. C. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508055608 · Cited by 257 · see citing works
The intestinal microbiome, probiotics and prebiotics in neurogastroenterology
Saulnier, D. M., Ringel, Y., Heyman, M. B., Foster, J. A., Bercik, P., Shulman, R. J., Versalovic, J., Verdu, E. F., Dinan, T. G., Hecht, G., et al. (2013) · Gut Microbes · doi:10.4161/gmic.22973 · Cited by 248 · see citing works
Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota
Noor, S. O., Ridgway, K., Scovell, L., Kemsley, E. K., Lund, E. K., Jamieson, C., Johnson, I. T., & Narbad, A. (2010) · BMC Gastroenterology · doi:10.1186/1471-230x-10-134 · Cited by 227 · see citing works
The human gut microbiome in health: Establishment and resilience of microbiota over a lifetime
Greenhalgh, K., Meyer, K. M., Aagaard, K. M., & Wilmes, P. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13318 · Cited by 218 · see citing works
Leveraging diet to engineer the gut microbiome
Wolter, M., Grant, E. T., Boudaud, M., Steimle, A., Pereira, G. V., Martens, E. C., & Desai, M. S. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00512-7 · Cited by 211 · see citing works
Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults
Kekkonen, R. A., Lummela, N., Karjalainen, H., Latvala, S., Tynkkynen, S., Järvenpää, S., Kautiainen, H., Julkunen, I., Vapaatalo, H., & Korpela, R. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2029 · Cited by 223 · see citing works
Tamaki, H., Nakase, H., Inoue, S., Kawanami, C., Itani, T., Ohana, M., Kusaka, T., Uose, S., Hisatsune, H., Tojo, M., et al. (2016) · Digestive Endoscopy · doi:10.1111/den.12553 · Cited by 214 · see citing works
Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation
Riedel, C. U. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i23.3729 · Cited by 210 · see citing works
Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases
Huang, E. Y., Inoue, T., Leone, V. A., Dalal, S., Touw, K., Wang, Y., Musch, M. W., Theriault, B., Higuchi, K., Donovan, S., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000332 · Cited by 204 · see citing works
Ishikawa, H., Matsumoto, S., Ohashi, Y., Imaoka, A., Setoyama, H., Umesaki, Y., Tanaka, R., & Otani, T. (2011) · Digestion · doi:10.1159/000322977 · Cited by 197 · see citing works
Immunological properties of inulin-type fructans
Vogt, L., Meyer, D., Pullens, G., Faas, M., Smelt, M., Venema, K., Ramasamy, U., Schols, H. A., & De Vos, P. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.656772 · Cited by 195 · see citing works
Zhang, X.-F., Guan, X.-X., Tang, Y.-J., Sun, J.-F., Wang, X.-K., Wang, W.-D., & Fan, J.-M. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02503-5 · Cited by 193 · see citing works
Miele, E., Shamir, R., Aloi, M., Assa, A., Braegger, C., Bronsky, J., de Ridder, L., Escher, J. C., Hojsak, I., Kolaček, S., et al. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001896 · Cited by 191 · see citing works
Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders
Currò, D., Ianiro, G., Pecere, S., Bibbò, S., & Cammarota, G. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13632 · Cited by 160 · see citing works
Roller, M., Clune, Y., Collins, K., Rechkemmer, G., & Watzl, B. (2007) · British Journal of Nutrition · doi:10.1017/s0007114507450292 · Cited by 125 · see citing works
The role of gut microbiota in human obesity: Recent findings and future perspectives
Tagliabue, A., & Elli, M. (2013) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.09.002 · Cited by 118 · see citing works
Synbiotics for Improved Human Health: Recent Developments, Challenges, and Opportunities
Krumbeck, J. A., Walter, J., & Hutkins, R. W. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030117-012757 · Cited by 84 · see citing works
Dore, M. P., Bibbò, S., Fresi, G., Bassotti, G., & Pes, G. M. (2019) · Nutrients · doi:10.3390/nu11122913 · Cited by 83 · see citing works
Van den Abbeele, P., Verstrepen, L., Ghyselinck, J., Albers, R., Marzorati, M., & Mercenier, A. (2020) · Nutrients · doi:10.3390/nu12071917 · Cited by 73 · see citing works
The Yin and Yang of Bacterial Resilience in the Human Gut Microbiota
Gibson, M. K., Pesesky, M. W., & Dantas, G. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.05.029 · Cited by 71 · see citing works
Cheng, Y., Jin, U.-H., Davidson, L. A., Chapkin, R. S., Jayaraman, A., Tamamis, P., Orr, A., Allred, C., Denison, M. S., Soshilov, A., et al. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfw230 · Cited by 48 · see citing works
Effects of probiotics on the gastrointestinal tract
Snelling, A. M. (2005) · Current Opinion in Infectious Diseases · doi:10.1097/01.qco.0000182103.32504.e3 · Cited by 46 · see citing works
Farewell to Animal Testing: Innovations on Human Intestinal Microphysiological Systems
Kang, T., & Kim, H. (2016) · Micromachines · doi:10.3390/mi7070107 · Cited by 40 · see citing works
Bacterial biofilms associated with food particles in the human large bowel
Van Wey, A. S., Cookson, A. L., Roy, N. C., McNabb, W. C., Soboleva, T. K., & Shorten, P. R. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000589 · Cited by 31 · see citing works
Anadón, A., Martínez-Larrañaga, M. R., Ares, I., & Martínez, M. A. (2016) · Nutraceuticals · doi:10.1016/b978-0-12-802147-7.00055-3 · Cited by 24 · see citing works
Probiotic use in irritable bowel syndrome
Young, P., & Cash, B. D. (2006) · Current Gastroenterology Reports · doi:10.1007/s11894-006-0053-1 · Cited by 22 · see citing works
Probiotics: Origin, Products, and Regulations in India
Narula, A. (2021) · Microorganisms for Sustainability · doi:10.1007/978-981-16-1947-2_4 · Cited by 6 · see citing works
Finamore, A., Peluso, I., & Serafini, M. (2016) · Probiotics, Prebiotics, and Synbiotics · doi:10.1016/b978-0-12-802189-7.00041-1 · Cited by 4 · see citing works
- Authors
- Furrie, E., Macfarlane, S., Kennedy, A., Cummings, J. H., Walsh, S. V., O’Neil, D. A., & Macfarlane, G. T.
- Affiliations
- University of Dundee (GB)
- Ninewells Hospital (GB)
- University of Aberdeen (GB)
- Corresponding author
- Furrie, E
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2005-01-11
- Volume
- 54
- Issue
- 2
- Pages
- 242-249
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1774839
- OpenAlex
- W2131691027
- Cited by
- 766
- References
- 44
- Citations by year
- 2026: 17 · 2025: 33 · 2024: 32 · 2023: 32 · 2022: 34 · 2021: 43 · 2020: 35 · 2019: 33 · 2018: 27 · 2017: 29 · 2016: 31 · 2015: 30 · 2014: 37 · 2013: 28 · 2012: 41
- FWCI
- 25.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- ulcerative colitis, Bifidobacterium longum, probiotics, prebiotics, gut microbiota, inflammation resolution, human beta-defensins, TNF-α, interleukin-1 alpha, rectal mucosa, epithelial regeneration, commensal bacteria
- MeSH terms
- Adult, Aged, Bifidobacterium, Biopsy, C-Reactive Protein, Colitis, Ulcerative, Double-Blind Method, Female, Humans, Intestinal Mucosa, Male, Middle Aged, Oligosaccharides, Pilot Projects, Rectum, RNA, Messenger, Sigmoidoscopy, Gene Expression, Cytokines, Treatment Outcome, Inflammation Mediators, Probiotics, beta-Defensins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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