Cited by 379Bacterial biofilms and quorum sensingGut microbiota and healthOral microbiology and periodontitis research

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Microbial biofilms in the human gastrointestinal tract

Macfarlane, S., Dillon, J.F.·2007·Journal of Applied Microbiology

DOI 10.1111/j.1365-2672.2007.03287.x

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Abstract

The human gastrointestinal tract contains rich and diverse microbiotas along its length. However, while extensive studies have been made on lumenal bacterial communities in the gut, less work has been carried out on organisms growing in biofilms, where individual groups of bacteria exist in a multiplicity of different microhabitats and metabolic niches associated with the mucosa, the mucus layer and particulate surfaces in the gut lumen. Bacteria and yeasts also occur in biofilms attached to artificial surfaces and devices implanted in the host, such as in patients being fed via enteral tubes. Although we are just beginning to investigate the composition and metabolic activities of these structures, increasing evidence suggests that they are important to the host in both health and disease. There is mounting interest in mucosal biofilms in the colon, especially with respect to their role in inflammatory bowel disease. Because bacteria growing in biofilms are more resistant to antibiotics than unattached organisms, it is often difficult to modify the structure and composition of these communities, or to eradicate them from the body. However, recent work has shown that there is considerable potential to alter the species composition of mucosal biofilms in a beneficial way using synbiotics.

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Unveiling the role of outer membrane proteins (OMPs) in biofilm formation and Harnessing them for targeting biofilm-forming bacterial infections
Vadaga, B. S., Sharma, S., Batchu, R., Dasgupta, M., & Kodgire, P. (2026) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-025-04732-w · Cited by 5
“According to statistics from the National Institutes of Health and the Centers for Disease Control, biofilm-forming bacteria cause 75% of human illnesses (Macfarlane and Dillon 2007 ; Wrzosek et nutrients (Horne et al. 2020 ).”
Assessing the impact of heavy metal residues in food and drug packaging on the standard bacterial strains: a biofilm perspective
Mukhi, S., Dhanashree, B., Srikantiah, R. M., Manjrekar, P., & Harish, S. (2023) · CyTA - Journal of Food · doi:10.1080/19476337.2023.2279187 · Cited by 5
“Metals can also influence cell surface adhesion and/or cell-to-cell aggregation process, promoting biofilm formation and, consequently, its resistance (Macfarlane & Dillon, 2007).”
Background
Effects of Weevil (Rhynchophorus palmarum), Teosinte (Dioon mejiae) and Caesar’s Mushroom (Amanita caesarea) on the Properties of Lactobacillus acidophilus LA-K
Alemán, R. S., Avila, D., Avila, A., Marcía, J., Picha, D. H., Aryana, K. J., & Fernández, I. M. (2023) · Fermentation · doi:10.3390/fermentation9090852 · Cited by 5
Chapter 2: The composition and role of the microbiota in chickens
Pedroso, A. A., & Lee, M. D. (2014) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-792-9_2 · Cited by 11
Interactions between potentially pathogenic fungi and natural human microbiota.
Góralska, K. (2014) · PubMed · Cited by 5
Neurological disorders associated with impaired gut microbiota
Kanhere, H. S., Rahangdale, Y. U., Bodele, A. S., Wadhwani, D. I., Ghoshewar, A. R., & Karande, S. P. (2021) · GSC Biological and Pharmaceutical Sciences · doi:10.30574/gscbps.2021.15.2.0121 · Cited by 5
“Just two hours of exposure to a social stressor will drastically alter the population profile and decrease the relative proportions of the major microbiota phyla [37].”
Background
Effect of intestinal microbiome, antibiotics, and probiotics in the prevention and management of ulcerative colitis
Kushkevych, I. V., & Jampílek, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00016-7 · Cited by 5
Construction of a model of the human proximal colon
Jiménez-Vera, R., Monroy, O., Corona-Cruz, A. I., & García‐Garibay, M. (2008) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-008-9803-6 · Cited by 5
“Most of this activity takes place in the lower intestinal system, in which important metabolites such as short chain fatty acids (SCFA) are produced (Gill et al. 2006; Macfarlane and Macfarlane 2006; Louis et al. 2007; Macfarlane and Dillon 2007 ).”
Background
Chemical Characterization and Impact of Nipple Fruit (Solanum mammosum) on the Characteristics of Lactobacillus acidophilus LA K
Aleman, R. S., Avila, D., Avila, A., Losso, J. N., Picha, D., Xu, Z., & Aryana, K. (2023) · Fermentation · doi:10.3390/fermentation9080715 · Cited by 4
Cellular and Microbial In Vitro Modelling of Gastrointestinal Cancer
Žukauskaitė, K., Li, M., Horvath, A., Jarmalaitė, S., & Stadlbauer, V. (2024) · Cancers · doi:10.3390/cancers16173113 · Cited by 4
“Nevertheless, to simulate the different parts of the GI tract, multi-vessel models consisting of multiple reactors have been invented [69–71].”
DISSIMILATORY SULFATE REDUCTION BY VARIOUS DESULFOVIBRIO SP. STRAINS OF THE HUMAN INTESTINE
Кушкевич, I. В. (2013) · Microbiology&Biotechnology · doi:10.18524/2307-4663.2013.3(23).48939 · Cited by 4
FISH analysis of Lactobacillus biofilms in the gastrointestinal tract of different hosts
Lebeer, S., Verhoeven, T. L. A., Claes, I. J. J., Hertogh, G., Vermeire, S., Buyse, J., Immerseel, F. V., Vanderleyden, J., & Keersmaecker, S. C. J. D. (2011) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2011.02994.x · Cited by 4
Neural control of redox response and microbiota-triggered inflammation in Drosophila gut
Fuse, N., Hashiba, H., Ishibashi, K., Suzuki, T., Nguyen, Q., Fujii, K., Ikeda‐Ohtsubo, W., Kitazawa, H., Tanimoto, H., & Kurata, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1268611 · Cited by 4
Compositional changes in fecal microbiota in a new Parkinson's disease model: C57BL/6-Tg(NSE-haSyn) mice
Kim, J. E., Kwon, K.-C., Jin, Y. J., Seol, A., Song, H. J., Roh, Y. J., Kim, T. R., Park, E. S., Park, G. H., Park, J. W., et al. (2023) · Laboratory Animal Research · doi:10.1186/s42826-023-00181-4 · Cited by 4
“These cells are affected by the gut microbiota through the regulation of mucus and biofilm production, gastrointestinal (GI) motility, GI permeability, and immune response [5].”
Background
Share of the Saccharomyces genus in the mycobiota of the gastrointestinal tract of oncology patients – potential effects of a fruit-based diet
Glinka, P., Nowacka, K., Kulesza, K., Ejdys, E., & Dynowska, M. (2018) · PubMed · doi:10.17420/ap6403.152 · Cited by 4
Characterization of Escherichia coli colonizing the gastrointestinal tract and urinary tract catheters
Wang, X. (2008) · Figshare · Cited by 4
Do the Physical Structure and Physicochemical Characteristics of Dietary Fibers Influence their Health Effects?
Fardet, A. (2016) · Wiley eBooks · doi:10.1002/9781119138105.ch1 · Cited by 4
Influence of the Microbiota Through the Gut-Brain Axis in Neurological Diseases
Guarnotta, V., Mandarino, F. V., Fasulo, E., Maida, M. F., Laterza, L., Sferrazza, S., Raimondo, D., & Sinagra, E. (2024) · Integrated science · doi:10.1007/978-3-031-73061-0_20 · Cited by 3
Free-standing bacterial films reinforced with 2D layered double hydroxide nanosheets: A biohybrid platform toward engineered living materials
Gurianov, Y., Shlar, I., & Poverenov, E. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.07.034 · Cited by 3
The Emerging Role of the Brain–Gut Axis in Amyotrophic Lateral Sclerosis: Pathogenesis, Mechanisms, and Therapeutic Perspectives
Yang, E. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178419 · Cited by 5
“Furthermore, Macfarlane et al. [81] proposed that ANS dysfunction in ALS may directly affect microbial populations by altering gut physiology.”
Food-residue-level antibiotics promote mucosal colonization of foodborne antibiotic-resistant Staphylococcus aureus in a simulated human gut
Yan, Z., Zhang, X., Shum, T., Xie, J., Chiou, J. A., Yu, J. Q., & Li, X. D. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2599517 · Cited by 5
“63 The enrichment of biofilm formation and quorum-sensing pathways further suggests a greater potential for biofilm development in mucosal communities, 64 enhancing microbial communication and cooperation.”
Association between the Gut Microbiota and the Pathophysiology of Irritable Bowel Syndrome: A Narrative Review
Andoh, A., & Miwa, H. (2026) · Digestion · doi:10.1159/000550907 · Cited by 4
Adaptation of Enterococcus faecalis to intestinal mucus revealed by a human colonic organoid model
Mikhaleva, S., Hsiao, P.-L., Kurmashev, A., Anderson, C. M., Colomer‐Winter, C., Boos, J. A., Choo, P. Y., Willett, J. L. E., Hierlemann, A. R., Kline, K. A., et al. (2026) · mSystems · doi:10.1128/msystems.01304-25 · Cited by 3
“Our findings show that Ef strongly prefers the mucosal niche, rapidly attaches, and forms robust, biofilm-like colonies, as previously reported in both germ-free mouse models and patient-derived intestinal samples (12, 35).”
Autonomic nervous system dysfunction in irritable bowel syndrome: pathophysiology and therapeutic implications
Bai, Y., Yu, M., Weng, C., Xu, J., Zheng, M., & Lv, B. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1832540 · Cited by 4
Cooperation and bacterial pathogenicity: an approach to social evolution
Molina, C. A., & Vı́lchez, S. (2014) · Revista chilena de historia natural · doi:10.1186/s40693-014-0014-2 · Cited by 3
“An interesting case study is that of the human microbiome, particularly that of the intestine, where the cells can form dense biofilms containing various species (Macfarlane and Dillon 2007).”
Background
Functional Microbial Landscapes
Ciccarese, D., & Johnson, D. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-64046-8.00472-9 · Cited by 3
FliI Role in Flagellar Assembly of Salmonella ΔfliI Mutant Strain Determines Motility and Biofilm Formation
Liaqat, I., Mirza, S. A., Sajjad, S., Ali, S., Qamar, M. F., & Haq, I. U. (2020) · Pakistan Journal of Zoology · doi:10.17582/journal.pjz/20190628120649 · Cited by 3
“Additionally other factors including fimbriae, pili, curli may also contribute to decreased biofilm formation in non flagellar strains (Reisner et al., 2006; Lemon et al., 2007; MacFarlane and Dillon, 2007; Kim et al., 2008; Liaqat and Sakellaris, 2012).”
Background
Pseudomonas Aeruginosa Biofilm: Role of Exopolysaccharides in the Function and Architecture of the Biofilm
Ghafoor, A. (2014) · Journal of Infection and Molecular Biology · doi:10.14737/jimb.2307-5465/2.4.61.73 · Cited by 3
“These biofilms develop a relationship with the host which may be beneficial or harmful for the host [reviewed in (Macfarlane and Dillon, 2007)] .”
Advanced acuity in microbial biofilm genesis, development, associated clinical infections and control
Kumar, P., Mishra, S., & Singh, S. (2017) · Journal des Anti-infectieux · doi:10.1016/j.antinf.2017.01.002 · Cited by 3
Human Intestinal Microbial Biofilm and its Correlation with Intestinal Mucin Secretion
Williams, K., Bekele, A. Z., Gokulan, K., & Khare, S. (2015) · doi:10.1002/9781118864036.ch9 · Cited by 3
Lactobacilli in the normal microbiota and probiotic effects of Lactobacillus plantarum
Lönnermark, E. (2010) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 3
Phage Probiotics
Wong, S. L. (2016) · SpringerBriefs in biochemistry and molecular biology · doi:10.1007/978-3-319-45791-8_5 · Cited by 2
Pittadhara Kala Sahayo Majjadhara Kala and brain gut microbiota axis: A comparative review study
Tiwari, R., & Pandey, B. (2022) · Journal of Ayurveda · doi:10.4103/joa.joa_290_20 · Cited by 2
Impact of galacto-oligosaccharides on prebiotic potential in the intestinal microbiota fermentation and health status in an animal model
Bajwa, A. A., Iqbal, S., Sohaib, M., Nasir, M., & Anjum, A. A. (2023) · Food Science and Technology · doi:10.5327/fst.88922 · Cited by 2
“Due to emerging prebiotics, this concept has been challenged, and there is growing acceptance that minor variations in dietary strategies can alter microbiota composition and physiological functions related to them (Macfarlane & Dillon, 2007).”
Background
The gut microbiota-brain axis role in neurodegenerative diseases and implications according to the sex
Mora-Ortiz, M., García-Fernández, H., Pérez‐Martínez, P., & Camargo, A. (2024) · Open Research Europe · doi:10.12688/openreseurope.18568.1 · Cited by 2
Non-invasive optical quantification of otitis media and middle ear effusions
Monroy, G. L. (2014) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign) · Cited by 2
Methods in Computational Biology
Carlson, R. P., & Sauro, H. M. (2019) · MDPI eBooks · doi:10.3390/books978-3-03921-164-7 · Cited by 2
Effect of iron and sodium chloride on biofilm development of stenotrophomonas maltophilia
Martinez, R. F. (2011) · Digital Commons-DePaul (DePaul University) · Cited by 2
Contribution of biofilm genes to adherence of Escherichia coli O157:H7 to epithelial cells
Stephenson, M. (2012) · doi:10.31274/etd-180810-533 · Cited by 2
“In addition, biofilms are potential causes in the pathogenesis of otitis media (179), tonsillitis (36) and lung infections in cystic fibrosis patients (81).”
Background

Authors: Macfarlane, S., & Dillon, J. F.
Affiliations: University of Dundee (GB)
Corresponding author: Macfarlane, S.
ORCID: Macfarlane, S.
Dillon, J.F.
Venue: Journal of Applied Microbiology
Publisher: Oxford University Press (OUP)
Published: 2007-05
Volume: 102
Issue: 5
Pages: 1187-1196
ISSN: 1364-5072 (ISSN-L)
1365-2672
DOI: 10.1111/j.1365-2672.2007.03287.x
OpenAlex: W2041418306
Cited by: 379
References: 55
Citations by year: 2026: 11 · 2025: 10 · 2024: 20 · 2023: 26 · 2022: 24 · 2021: 25 · 2020: 28 · 2019: 31 · 2018: 22 · 2017: 26 · 2016: 14 · 2015: 17 · 2014: 32 · 2013: 16 · 2012: 20
FWCI: 0.98
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3045 d)
Locations: Journal of Applied Microbiology (publishedVersion)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: biofilm, gastrointestinal tract, gut microbiota, mucus layer, inflammatory bowel disease, antibiotic resistance, synbiotics
MeSH terms: Bacteria, Humans, Intestinal Mucosa, Biofilms, Probiotics, Gastrointestinal Tract

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Microbial biofilms in the human gastrointestinal tract

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