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Mild cognitive impairment – Beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment.
Open accessAbstract
Abstract.: The First Key Symposium was held in Stockholm, Sweden, 2–5 September 2003. The aim of the symposium was to integrate clinical and epidemiological perspectives on the topic of Mild Cognitive Impairment (MCI). A multidisciplinary, international group of experts discussed the current status and future directions of MCI, with regard to clinical presentation, cognitive and functional assessment, and the role of neuroimaging, biomarkers and genetics. Agreement on new perspectives, as well as recommendations for management and future research were discussed by the international working group. The specific recommendations for the general MCI criteria include the following: (i) the person is neither normal nor demented; (ii) there is evidence of cognitive deterioration shown by either objectively measured decline over time and/or subjective report of decline by self and/or informant in conjunction with objective cognitive deficits; and (iii) activities of daily living are preserved and complex instrumental functions are either intact or minimally impaired.
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“It seems quite obvious that both the dementia severity in AD patients and the pattern of cognitive deficits in MCI patients (only amnestic, amnestic plus other domains, or not amnestic at all [41]) have a great impact on the expected pattern of hippocampal regional atrophy.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [41]
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Items 201–209 of 209
Song, I.-U., Choi, E. K., Oh, J. K., Chung, Y.-A., & Chung, S.-W. (2016) · Acta Radiologica · doi:10.1177/0284185114566088 · Cited by 17
Schjønning Nielsen, M., Simonsen, A. H., Siersma, V., Engedal, K., Jelic, V., Andersen, B. B., Naik, M., Hasselbalch, S. G., & Høgh, P. (2018) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000490788 · Cited by 15
Self-citationSuhonen, N.-M., Hallikainen, I., Hänninen, T., Jokelainen, J., Krüger, J., Hall, A., Pikkarainen, M., Soininen, H., & Remes, A. M. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160983 · Cited by 14
Pilot Testing a Couples-Focused Intervention for Mild Cognitive Impairment
Lu, Y. Y.-F., Haase, J. E., & Weaver, M. (2013) · Journal of Gerontological Nursing · doi:10.3928/00989134-20130403-01 · Cited by 11
“Excluded were those with significant neurologic disease other than suspected incipient AD or current major depression (Winblad et al., 2004).”
BackgroundLim, B., Fowler, C., Li, Q.-X., Rowe, C., Dhiman, K., Gupta, V. B., Masters, C. L., Doecke, J. D., Martins, R. N., Collins, S., et al. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135078 · Cited by 10
Ye, Q., Chen, H., Liu, R., Qin, R., Luo, C., Li, M., Xu, Y., Zhao, H., & Bai, F. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.756241 · Cited by 6
Ekman, U., Kemani, M. K., Wallert, J., Wicksell, R. K., Holmström, L., Ngandu, T., Rennie, A., Akenine, U., Westman, E., & Kivipelto, M. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.600841 · Cited by 5
“In addition, depression or depressive symptoms are common in clinical settings, potentially reaching a prevalence of over 40% for individuals with MCI, and sub-clinical depressive symptoms are associated with the increased use of healthcare (Meeks et al., 2011).”
BackgroundMethodInfluentialSelf-citationDichgans, M., & Leys, D. (2017) · Circulation Research · doi:10.1161/circresaha.116.308426 · Cited by 581
Pearce, L. A., McClure, L. A., Anderson, D. C., Jacova, C., Sharma, M., Hart, R. G., & Benavente, O. R. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70224-8 · Cited by 135
Metadata
- Authors
- Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L. ‐., Nordberg, A., Bäckman, L., Albert, M., Almkvist, O., Arai, H., Basun, H., Blennow, K., De Leon, M., DeCarli, C., Erkinjuntti, T., Giacobini, E., Graff, C., Hardy, J., Jack, C., Jorm, A., Ritchie, K., Van Duijn, C., Visser, P., & Petersen, R. C.
- Affiliations
- Karolinska Institutet (SE)
- Johns Hopkins University (US)
- Tohoku University (JP)
- Uppsala University (SE)
- University of Gothenburg (SE)
- University of California, Davis (US)
- University of Helsinki (FI)
- University of Geneva (CH)
- National Institutes of Health (US)
- Mayo Clinic (US)
- Australian National University (AU)
- Inserm (FR)
- Maastricht University (NL)
- Corresponding author
- Winblad, B.
- ORCID
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2004-08-20
- Volume
- 256
- Issue
- 3
- Pages
- 240-246
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2055649795
- Cited by
- 4,946
- References
- 0
- Citations by year
- 2026: 157 · 2025: 234 · 2024: 272 · 2023: 228 · 2022: 267 · 2021: 271 · 2020: 306 · 2019: 292 · 2018: 248 · 2017: 263 · 2016: 267 · 2015: 284 · 2014: 256 · 2013: 263 · 2012: 254
- FWCI
- 54.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- mild cognitive impairment, diagnostic criteria, cognitive decline, activities of daily living, functional assessment, neuroimaging, biomarkers, dementia prevention, clinical management guidelines
- MeSH terms
- Aged, Cognition Disorders, Diagnostic Imaging, Humans, Neuropsychological Tests, Biomarkers, Biomedical Research
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