The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Low testosterone levels are associated with carotid atherosclerosis in men
Abstract
Abstract.: Objective. To study the relationship between endogenous sex hormone levels and intima‐media thickness (IMT) of the carotid artery measured by ultrasonography. Design. Population‐based cross‐sectional study. Methods. Sex hormone levels measured by immunoassay, anthropometric measurements and IMT was studied in 1482 men aged 25–84 years participating in the 1994–1995 Tromsø study. The data were analysed with partial correlation, multiple linear regression and logistic regression analysis. Results. Linear regression models showed that total testosterone and sex hormone‐binding globulin levels, but not calculated free testosterone, serum oestradiol or dehydroepiandrosterone sulphate levels were inversely associated with the age‐adjusted IMT (P = 0.008 and P < 0.001 respectively). These associations were independent of smoking, physical activity, blood pressure and lipid levels, but were not independent of body mass index (BMI). Excluding men with cardiovascular disease (CVD) did not materially change these results. In a logistic regression model adjusted for the confounding effect of CVD risk factors, men with testosterone levels in the lowest quintile (<9.0 nmol L−1) had an independent OR = 1.51 (P = 0.015) of being in the highest IMT quintile. Conclusions. We found an inverse association between total testosterone levels and IMT of the carotid artery in men that was present also after excluding men with CVD, but was not independent of BMI. The clinical relevance of this, however, is uncertain and needs to be investigated in a clinical setting.
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Cites
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
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Effect of Testosterone Treatment on Body Composition and Muscle Strength in Men Over 65 Years of Age
Snyder, P. J. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.8.2647 · Cited by 531
Effects of Testosterone on Coronary Vasomotor Regulation in Men With Coronary Heart Disease
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Self-citationWaist Circumference and Testosterone Levels in Community Dwelling Men. The Tromsø Study
Svartberg, J., von Mühlen, D., Sundsfjord, J., & Jorde, R. (2004) · European Journal of Epidemiology · doi:10.1023/b:ejep.0000036809.30558.8f · Cited by 229
Self-citationHerrington, D. M., Gordon, G. B., Achuff, S. C., Trejo, J. F., Weisman, H. F., Kwiterovich, P. O., & Pearson, T. A. (1990) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(10)80334-1 · Cited by 147
Sex hormones and hemostatic risk factors for coronary heart disease in men with hypertension
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Cited by
Muraleedharan, V., Marsh, H., Kapoor, D., Channer, K. S., & Jones, T. H. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0321 · Cited by 389
Genetic determinants of serum testosterone concentrations in men
Ohlsson, C., Wallaschofski, H., Lunetta, K. L., Stolk, L., Perry, J. R. B., Koster, A., Petersen, A.-K., Eriksson, J., Lehtimäki, T., Huhtaniemi, I. T., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002313 · Cited by 224
Association of Sex Hormones, Aging, and Atrial Fibrillation in Men: The Framingham Heart Study
Magnani, J. W., Moser, C. B., Murabito, J. M., Sullivan, L. M., Wang, N., Ellinor, P. T., Vasan, R. S., Benjamin, E. J., & Coviello, A. D. (2014) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.113.001322 · Cited by 112
Endogenous testosterone levels and smoking in men. The fifth Tromsø study
Svartberg, J., & Jorde, R. (2007) · International Journal of Andrology · doi:10.1111/j.1365-2605.2006.00720.x · Cited by 111
Self-citationSvartberg, J., Schirmer, H., Wilsgaard, T., Mathiesen, E. B., Njølstad, I., Løchen, M.-L., & Jorde, R. (2014) · Andrology · doi:10.1111/j.2047-2927.2013.00174.x · Cited by 32
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Metadata
- Authors
- SVARTBERG, J., VON MÜHLEN, D., MATHIESEN, E., JOAKIMSEN, O., BØNAA, K. H., & STENSLAND‐BUGGE, E.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2006-03-24
- Volume
- 259
- Issue
- 6
- Pages
- 576-582
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2022894974
- Cited by
- 164
- References
- 9
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- closed
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