Effects of Testosterone on Coronary Vasomotor Regulation in Men With Coronary Heart Disease
Abstract
Background —The increased incidence of coronary artery disease in men compared with premenopausal women suggests a detrimental role of male hormones on the cardiovascular system. However, testosterone has direct relaxing effects on coronary arteries in animals, as shown both in vitro and in vivo. The effect of testosterone on the human coronary circulation remains unknown. Methods and Results —We studied 13 men (aged 61±11 years) with coronary artery disease. They underwent measurement of coronary artery diameter and blood flow after a 3-minute intracoronary infusion of vehicle control (ethanol) followed by 2-minute intracoronary infusions of acetylcholine (10 −7 to 10 −5 mol/L) until peak velocity response. A dose-response curve to 3-minute infusions of testosterone (10 −10 to 10 −7 mol/L) was then determined, and the acetylcholine infusions were repeated. Finally, an intracoronary bolus of isosorbide dinitrate (1000 μg) was given. Coronary blood flow was calculated from measurements of blood flow velocity using intracoronary Doppler and coronary artery diameter using quantitative coronary angiography. Testosterone significantly increased coronary artery diameter compared with baseline (2.78±0.74 mm versus 2.86±0.72 mm [ P =0.05], 2.87±0.71 mm [ P =0.038], and 2.90±0.75 mm [ P =0.005] for baseline versus testosterone 10 −9 to 10 −7 mol/L, respectively). A significant increase in coronary blood flow occurred at all concentrations of testosterone compared with baseline (geometric mean [95% CI]: 32 [25, 42] versus 36.3 [27, 48] { P =0.006}, 35.3 [26, 47] { P =0.029}, 36.8 [28, 49] { P =0.002}, and 37 [28, 48] { P =0.002} mL/min for baseline versus testosterone 10 −10 to 10 −7 mol/L, respectively). No differences existed in coronary diameter or blood flow responses to acetylcholine before versus after testosterone. Conclusions —Short-term intracoronary administration of testosterone, at physiological concentrations, induces coronary artery dilatation and increases coronary blood flow in men with established coronary artery disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In vitro and in vivo studies have found testosterone to be a coronary vasodilator.
“In vitro and in vivo studies have found testosterone to be a coronary vasodilator.[11][12][13]”
From Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life (2004) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Stampfer, M. J., & Colditz, G. A. (1991) · Preventive Medicine · doi:10.1016/0091-7435(91)90006-p · Cited by 1,611 · see citing works
Gray, A., Feldman, H. A., McKinlay, J. B., & Longcope, C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1016 · Cited by 1,104 · see citing works
Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity.
Doucette, J. W., Corl, P. D., Payne, H. M., Flynn, A. E., Goto, M., Nassí, M., & Segal, J. (1992) · Circulation · doi:10.1161/01.cir.85.5.1899 · Cited by 1,017 · see citing works
Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women.
Gilligan, D. M., Quyyumi, A. A., & Cannon, R. O. (1994) · Circulation · doi:10.1161/01.cir.89.6.2545 · Cited by 546 · see citing works
Collins, P. D., Rosano, G. M. C., Sarrel, P. M., Ulrich, L. G., Adamopoulos, S. N., Beale, C. M., McNeill, J. G., & Poole-Wilson, P. A. (1995) · Circulation · doi:10.1161/01.cir.92.1.24 · Cited by 530 · see citing works
Self-citationAndrogens in Men — Uses and Abuses
Bagatell, C. J., & Bremner, W. J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603143341107 · Cited by 463 · see citing works
Testosterone Relaxes Rabbit Coronary Arteries and Aorta
Yue, P., Chatterjee, K., Beale, C., Poole-Wilson, P. A., & Collins, P. (1995) · Circulation · doi:10.1161/01.cir.91.4.1154 · Cited by 414 · see citing works
Self-citationThe association of hypotestosteronemia with coronary artery disease in men.
Phillips, G. B., Pinkernell, B. H., & Jing, T. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.5.701 · Cited by 400 · see citing works
Testosterone Induces Dilation of Canine Coronary Conductance and Resistance Arteries In Vivo
Chou, T. M., Sudhir, K., Hutchison, S. J., Ko, E., Amidon, T. M., Collins, P. D., & Chatterjee, K. (1996) · Circulation · doi:10.1161/01.cir.94.10.2614 · Cited by 312 · see citing works
Self-citationTestosterone Increases Human Platelet Thromboxane A2Receptor Density and Aggregation Responses
Ajayi, A. A. L., Mathur, R. S., & Halushka, P. V. (1995) · Circulation · doi:10.1161/01.cir.91.11.2742 · Cited by 307 · see citing works
Natural Androgens Inhibit Male Atherosclerosis
Alexandersen, P., Haarbo, J., Byrjalsen, I., Lawaetz, H., & Christiansen, C. (1999) · Circulation Research · doi:10.1161/01.res.84.7.813 · Cited by 251 · see citing works
Effect of acute testosterone on myocardial ischemia in men with coronary artery disease
Webb, C. M., Adamson, D. L., de Zeigler, D., & Collins, P. D. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00880-7 · Cited by 242 · see citing works
Self-citationDecreased Bioavailable Testosterone in Aging Normal and Impotent Men*
Nankin, H. R., & CALKINS, J. H. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-6-1418 · Cited by 238 · see citing works
Contrasting effects of testosterone and stanozolol on serum lipoprotein levels
Thompson, P. D. (1989) · JAMA · doi:10.1001/jama.261.8.1165 · Cited by 234 · see citing works
Adams, M. R., Williams, J. K., & Kaplan, J. R. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.5.562 · Cited by 209 · see citing works
Contrasting Effects of Testosterone and Stanozolol on Serum Lipoprotein Levels
Thompson, P. D. (1989) · JAMA · doi:10.1001/jama.1989.03420080085036 · Cited by 201 · see citing works
Nuclear uptake of sex steroid hormones in the cardiovascular system of the baboon.
McGill, H. C., & Sheridan, P. J. (1981) · Circulation Research · doi:10.1161/01.res.48.2.238 · Cited by 172 · see citing works
Effect of testosterone cypionate on postexercise ST segment depression.
Jaffe, M. D. (1977) · Heart · doi:10.1136/hrt.39.11.1217 · Cited by 155 · see citing works
Harman, S. M., Tsitouras, P. D., Costa, P. T., & Blackman, M. R. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-3-547 · Cited by 116 · see citing works
Hutchison, S. J., Sudhir, K., Chou, T. M., Sievers, R. E., Zhu, B., Sun, Y., DEEDWANIA, P. C., Glantz, S. A., Parmley, W. W., & Chatterjee, K. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00570-0 · Cited by 92 · see citing works
TESTOSTERONE PROPIONATE THERAPY IN ONE HUNDRED CASES OF ANGINA PECTORIS
Lesser, M. A. (1946) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-6-8-549 · Cited by 87 · see citing works
Higashiura, K., Mathur, R. S., & Halushka, P. V. (1997) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199703000-00002 · Cited by 58 · see citing works
The Therapeutic Value of Testosterone Propionate in Angina Pectoris
Levine, S. A., & LIKOFF, W. B. (1943) · New England Journal of Medicine · doi:10.1056/nejm194311182292102 · Cited by 44 · see citing works
Lin, A., Gonzalez, R., & Shain, S. A. (1985) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.5.6.659 · Cited by 23 · see citing works
Inter-relationships between factor VII, serum testosterone and plasma lipoproteins
Heller, R. F., Meade, T. W., Haines, A., Stirling, Y., Miller, N. E., & Lewis, B. (1982) · Thrombosis Research · doi:10.1016/0049-3848(82)90123-2 · Cited by 13 · see citing works
Haager, P. K., Klues, H. G., Schmidt, M., et al. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199901000-00019 · Cited by 10 · see citing works
A Guide to Medical Endocrinology
Hassan, T. A. (1985) · Cited by 5 · see citing works
Changes in Human Coronary Flow Reserve After Administration of Intracoronary Diltiazem
Vrolix, M., Sionis, D. G., Piessens, J., et al. (1991) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199100189-00014 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Hutchison SJ, Sudhir K, Chou TM, Sievers RE, Zhu BQ, Sun YP, Deedwania PC, Glantz SA, Parmley WW, Chatterjee K. Testosterone worsens endothelial dysfunction associated with hypercholesterolemia and environmental tobacco smoke exposure in male rabbit aorta. J Am Coll Cardiol. 1997;29:800 -807.
Cited by
Sorted by citations
Khaw, K.-T., Dowsett, M., Folkerd, E., Bingham, S., Wareham, N., Luben, R., Welch, A., & Day, N. (2007) · Circulation · doi:10.1161/circulationaha.107.719005 · Cited by 743 · see citing works
Risks of testosterone-replacement therapy and recommendations for monitoring.
Rhoden, E. L., & Morgentaler, A. (2004) · New England Journal of Medicine · doi:10.1056/nejmra022251 · Cited by 705 · see citing works
English, K. M., Steeds, R. P., Jones, T. H., Diver, M. J., & Channer, K. S. (2000) · Circulation · doi:10.1161/01.cir.102.16.1906 · Cited by 582 · see citing works
Andropause: clinical implications of the decline in serum testosterone levels with aging in men
Matsumoto, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.2.m76 · Cited by 490 · see citing works
Smith, J. C., Bennett, S., Evans, L. M., Kynaston, H. G., Parmar, M., Mason, M. D., Cockcroft, J. R., Scanlon, M. F., & Davies, J. S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7851 · Cited by 458 · see citing works
English, K. (2000) · European Heart Journal · doi:10.1053/euhj.1999.1873 · Cited by 350 · see citing works
Aversa, A., Isidori, A. M., Spera, G., Lenzi, A., & Fabbri, A. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01764.x · Cited by 343 · see citing works
Androgens, insulin resistance and vascular disease in men
Kapoor, D., Malkin, C. J., Channer, K. S., & Jones, T. H. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02299.x · Cited by 317 · see citing works
Testosterone and insulin resistance in the metabolic syndrome and T2DM in men
Rao, P. M., Kelly, D. M., & Jones, T. H. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.122 · Cited by 292 · see citing works
Malkin, C. J., Pugh, P. J., Morris, P. D., Kerry, K. E., Jones, R. D., Jones, T. H., & Channer, K. S. (2004) · Heart · doi:10.1136/hrt.2003.021121 · Cited by 250 · see citing works
Testosterone replacement therapy: current trends and future directions
Nieschlag, E., Behre, H. M., Bouchard, P., Corrales, J. J., Jones, T. H., Stalla, G. K., Webb, S. M., & Wu, F. C. W. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh035 · Cited by 224 · see citing works
Low Testosterone Level Is an Independent Determinant of Endothelial Dysfunction in Men
AKISHITA, M., HASHIMOTO, M., OHIKE, Y., OGAWA, S., IIJIMA, K., ETO, M., & OUCHI, Y. (2007) · Hypertension Research · doi:10.1291/hypres.30.1029 · Cited by 179 · see citing works
Jones, R. D., Pugh, P. J., Jones, T. H., & Channer, K. S. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705141 · Cited by 153 · see citing works
Groti, K., Žuran, I., Antonič, B., Foršnarič, L., & Pfeifer, M. (2018) · The Aging Male · doi:10.1080/13685538.2018.1468429 · Cited by 117 · see citing works
Kang, S.-M., Jang, Y., Kim, J. I.-Y., Chung, N., Cho, S.-Y., Chae, J. S., & Lee, J.-H. O. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02202-6 · Cited by 105 · see citing works
Vascular Dysfunction and Metabolic Parameters in Polycystic Ovary Syndrome
Meyer, C., McGrath, B. P., Cameron, J., Kotsopoulos, D., & Teede, H. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1487 · Cited by 101 · see citing works
Anawalt, B. D., & Merriam, G. R. (2001) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70206-1 · Cited by 93 · see citing works
Vascular Reactivity in Hypogonadal Men Is Reduced by Androgen Substitution
Zitzmann, M., Brune, M., & Nieschlag, E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020504 · Cited by 86 · see citing works
Effect of testosterone on <i>ex vivo</i> vascular reactivity in man
Malkin, C. J., Jones, R. D., Jones, T. H., & Channer, K. S. (2006) · Clinical Science · doi:10.1042/cs20050354 · Cited by 81 · see citing works
Body composition, metabolic syndrome and testosterone in ageing men
Allan, C. A., Strauss, B. J. G., & McLachlan, R. I. (2007) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901552 · Cited by 67 · see citing works
Hypogonadotropic Hypogonadism in Men with Type 2 Diabetes
Dandona, P., Dhindsa, S., Chandel, A., & Chaudhuri, A. (2009) · Postgraduate Medicine · doi:10.3810/pgm.2009.05.2001 · Cited by 47 · see citing works
Non‐genomic effects of androgens on isolated human vascular and nonvascular penile erectile tissue
Waldkirch, E., Ückert, S., Schultheiss, D., Geismar, U., Bruns, C., Scheller, F., Jonas, U., Becker, A. J., Stief, C. G., & Hedlund, P. (2008) · BJU International · doi:10.1111/j.1464-410x.2007.07182.x · Cited by 27 · see citing works
- Authors
- Webb, C. M., McNeill, J. G., Hayward, C. S., de Zeigler, D., & Collins, P.
- Affiliations
- Royal Brompton Hospital (GB)
- From Cardiac Medicine, National Heart and Lung Institute, Imperial College School of Medicine, and Royal Brompton Hospital, London, UK (C.M.W., J.G.M., C.S.H., P.C.), and Columbia Laboratories, Paris, France (D.d.Z).
- Venue
- Circulation
- Published
- 1999-10-19
- Volume
- 100
- Issue
- 16
- Pages
- 1690-1696
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2148746144
- Cited by
- 451
- References
- 28
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 4 · 2023: 9 · 2022: 9 · 2021: 8 · 2020: 11 · 2019: 12 · 2018: 9 · 2017: 17 · 2016: 10 · 2015: 18 · 2014: 18 · 2013: 21 · 2012: 22
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- British Heart Foundation
- National Heart Foundation of Australia
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- testosterone, coronary artery disease, coronary blood flow, coronary artery diameter, acetylcholine response, isosorbide dinitrate, androgens, coronary vasodilation, menopause, sex differences in cardiovascular disease, endothelium-dependent vasodilation, nitric oxide, nitric oxide synthase, nitric oxide synthase inhibition, nitric oxide donors
- MeSH terms
- Acetylcholine, Adult, Aged, Analysis of Variance, Blood Pressure, Coronary Circulation, Coronary Disease, Coronary Vessels, Female, Heart Rate, Hemodynamics, Humans, Hypercholesterolemia, Infusions, Intra-Arterial, Male, Middle Aged, Muscle, Smooth, Vascular, Sex Characteristics, Smoking, Testosterone, Coronary Angiography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
