The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Telomere attrition is associated with inflammation, low fetuin‐A levels and high mortality in prevalent haemodialysis patients
Abstract
Abstract.: Introduction. Chronic kidney disease (CKD) predisposes to a 10‐ to 20‐fold increased cardiovascular risk. Patients undergo accelerated atherogenesis and vascular ageing. We investigated whether telomere attrition, a marker of cell senescence, contributes to this increased mortality risk. Methods. This is a cross‐sectional study in prevalent haemodialysis patients [n = 175; 98 Males; median (range) age: 66 (23–86) years]. Biochemical markers of oxidative stress and inflammatory status were measured in relation to the patient’s leucocyte telomere length. Overall mortality was assessed after a median of 31 (range 2–42) months. Results. Telomere length was shorter in CKD men, despite women being older (average ± SD 6.41 ± 1.23 vs. 6.96 ± 1.48 kb, P = 0.002). Telomere length was associated with age (rho = −0.18, P = 0.01), fetuin‐A (rho = 0.26, P = 0.0004), high‐sensitivity C‐reactive protein (rho = −0.21, P = 0.005) and IL‐6 (rho = −0.17, P = 0.02). In a multivariate logistic regression (pseudo r2 = 0.14), telomere length was associated with age >65 years (odds ratio: 2.11; 95% CI: 1.10, 4.06), sex (2.01; 1.05, 3.86), fetuin‐A (1.85; 0.97, 3.50) and white blood cell count (2.04; 1.02, 4.09). Receiver operating characteristic curves identified a telomere length < 6.28 kb as a fair predictor of mortality. Finally, reduced telomere length was associated with increased mortality, independently of age, gender and inflammation (likelihood ratio 41.6, P < 0.0001), but dependently on fetuin‐A levels. Conclusion. Age and male gender seem to be important contributors to reduced telomere length in CKD patients, possibly via persistent inflammation. Reduced telomere length also contributes to the mortality risk of these patients through pathways that could involve circulating levels of fetuin‐A.
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Cites
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
What is subjective global assessment of nutritional status?
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Accelerated telomere shortening in response to life stress
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002
Association between telomere length in blood and mortality in people aged 60 years or older
Cawthon, R. M., Smith, K. R., O'Brien, E., Sivatchenko, A., & Kerber, R. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12384-7 · Cited by 1,761
The elephant in uremia: Oxidant stress as a unifying concept of cardiovascular disease in uremia
Himmelfarb, J., Stenvinkel, P., Ikizler, T. A., & Hakim, R. M. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00600.x · Cited by 1,179
Self-citationLeukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
Fitzpatrick, A. L., Kronmal, R. A., Gardner, J. P., Psaty, B. M., Jenny, N. S., Tracy, R. P., Walston, J., Kimura, M., & Aviv, A. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj346 · Cited by 773
White Cell Telomere Length and Risk of Premature Myocardial Infarction
Brouilette, S., Singh, R. K., Thompson, J. R., Goodall, A. H., & Samani, N. J. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000067426.96344.32 · Cited by 590
Short Telomeres Are Associated With Increased Carotid Atherosclerosis in Hypertensive Subjects
Benetos, A., Gardner, J. P., Zureik, M., Labat, C., Xiaobin, L., Adamopoulos, C., Temmar, M., Bean, K. E., Thomas, F., & Aviv, A. (2004) · Hypertension · doi:10.1161/01.hyp.0000113081.42868.f4 · Cited by 313
Serra, V., von Zglinicki, T., Lorenz, M., & Saretzki, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207939200 · Cited by 278
Valdes, A. M., Richards, J. B., Gardner, J. P., Swaminathan, R., Kimura, M., Xiaobin, L., Aviv, A., & Spector, T. D. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0357-5 · Cited by 164
Cited by
Van den Bergh, B. R. H., van den Heuvel, M. I., Lahti, M., Braeken, M., de Rooij, S. R., Entringer, S., Hoyer, D., Roseboom, T., Räikkönen, K., King, S., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.003 · Cited by 1,181
Stenvinkel, P., Carrero, J. J. A. A., Axelsson, J., Lindholm, B., Heimbu[Combining Diaeresis]rger, O., & Massy, Z. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03670807 · Cited by 561
Self-citationLin, J., Epel, E., Cheon, J., Kroenke, C., Sinclair, E., Bigos, M., Wolkowitz, O., Mellon, S., & Blackburn, E. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.09.012 · Cited by 426
Psychological and metabolic stress: A recipe for accelerated cellular aging?
Epel, E. S. (2009) · Hormones · doi:10.14310/horm.2002.1217 · Cited by 423
Inflammation in End-Stage Renal Disease-What Have We Learned in 10 Years?
Carrero, J. J., & Stenvinkel, P. (2010) · Seminars in Dialysis · doi:10.1111/j.1525-139x.2010.00784.x · Cited by 354
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Metadata
- Authors
- Carrero, J. J., Stenvinkel, P., Fellström, B., Qureshi, A. R., Lamb, K., Heimbürger, O., Bárány, P., Radhakrishnan, K., Lindholm, B., Soveri, I., Nordfors, L., & Shiels, P. G.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2007-12-07
- Volume
- 263
- Issue
- 3
- Pages
- 302-312
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2093417178
- Cited by
- 186
- References
- 13
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Carrero, J. J., Stenvinkel, P., Fellström, B., Qureshi, A. R., Lamb, K., Heimbürger, O., Bárány, P., Radhakrishnan, K., Lindholm, B., Soveri, I., Nordfors, L., & Shiels, P. G. (2008). Telomere attrition is associated with inflammation, low fetuin‐A levels and high mortality in prevalent haemodialysis patients. Journal of Internal Medicine. https://doi.org/10.1111/j.1365-2796.2007.01890.x
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