Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
Abstract
The telomere length of replicating somatic cells is inversely correlated with age and has been reported to be associated cross-sectionally with cardiovascular disease (CVD). Leukocyte telomere length, as expressed by mean terminal restriction fragment (TRF) length, was measured in 419 randomly selected participants from the Cardiovascular Health Study, comprising a community-dwelling cohort recruited in four US communities. The authors investigated associations between TRF length and selected measures of subclinical CVD/risk factors for CVD (data were collected at the 1992/1993 clinic visit) and incident CVD (ascertained through June 2002). In these participants (average age = 74.2 years (standard deviation, 5.2)), mean TRF length was 6.3 kilobase pairs (standard deviation, 0.62). Significant or borderline inverse associations were found between TRF length and diabetes, glucose, insulin, diastolic blood pressure, carotid intima-media thickness, and interleukin-6. Associations with body size and C-reactive protein were modified by gender and age, occurring only in men and in participants aged 73 years or younger. In younger (but not older) participants, each shortened kilobase pair of TRF corresponded with a threefold increased risk of myocardial infarction (hazard ratio = 3.08, 95% confidence interval: 1.22, 7.73) and stroke (hazard ratio = 3.22, 95% confidence interval: 1.29, 8.02). These results support the hypotheses that telomere attrition may be related to diseases of aging through mechanisms involving oxidative stress, inflammation, and progression to CVD.
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Inter-individual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases.
“Inter-individual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases.”
From Identification of seven loci affecting mean telomere length and their association with disease (2013) · cites this paper as [14]
In cross-sectional population studies, mean LTL is longer in women than in men and is inversely associated with age, declining by between 20-40 base pairs per year.
“In cross-sectional population studies mean LTL is longer in women than in men and is inversely associated with age (declining by between 20–40 base-pairs (bp) per year)9, 12–14.”
From Identification of seven loci affecting mean telomere length and their association with disease (2013) · cites this paper as [14]
Shorter age-and sex-adjusted mean LTL has been found to be associated with risk of several age-related diseases, including CAD.
“Furthermore, shorter age-and sex-adjusted mean LTL has been found to be associated with risk of several age-related diseases, including CAD12–15 and has been advanced as a marker of biological ageing16.”
From Identification of seven loci affecting mean telomere length and their association with disease (2013) · cites this paper as [14]
One of the most widely reported associations for LTL to date has been that between shorter mean LTL and CAD.
“One of the most widely reported associations for LTL to date has been that between shorter mean LTL and CAD12–14, 25.”
From Identification of seven loci affecting mean telomere length and their association with disease (2013) · cites this paper as [14]
Many prior studies using Southern blotting have shown that mean LTL attrition rate is about ~30 bp per year.
“However, many prior studies that have used Southern blotting to measure LTL have shown that mean LTL attrition rate is about ~30 bp per year8, 12–14, 25.”
From Identification of seven loci affecting mean telomere length and their association with disease (2013) · cites this paper as [14]
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- Authors
- Fitzpatrick, A. L., Kronmal, R. A., Gardner, J. P., Psaty, B. M., Jenny, N. S., Tracy, R. P., Walston, J., Kimura, M., & Aviv, A.
- Affiliations
- University of Washington (US)
- Rutgers, The State University of New Jersey (US)
- University of Vermont (US)
- Johns Hopkins University (US)
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-10-13
- Volume
- 165
- Issue
- 1
- Pages
- 14-21
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2136303436
- Cited by
- 773
- References
- 37
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 17 · 2023: 25 · 2022: 27 · 2021: 42 · 2020: 45 · 2019: 42 · 2018: 41 · 2017: 50 · 2016: 43 · 2015: 53 · 2014: 71 · 2013: 54 · 2012: 47
- FWCI
- 21.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- American Diabetes Association
- Healthcare Foundation of New Jersey
- National Institutes of Health (n01hc085079-024, n01hc015103-009, n01hc085086-022, n01hc035129-010)
- National Heart, Lung, and Blood Institute (N01HC15103, N01 HC85086, N01-HC85079, N01HC35129)
- National Institute of Neurological Disorders and Stroke
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- leukocyte telomere length, telomere shortening, cardiovascular disease, terminal restriction fragments, myocardial infarction, stroke, carotid intima-media thickness, interleukin-6, C-reactive protein, diabetes mellitus, blood pressure, oxidative stress, inflammation, aging, community-dwelling older adults
- MeSH terms
- Aged, Cardiovascular Diseases, DNA, Female, Humans, Inflammation, Leukocytes, Male, Myocardial Infarction, Pilot Projects, Polymorphism, Restriction Fragment Length, Risk, Risk Factors, Telomere, Oxidative Stress, Risk Assessment
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