Cited by 214Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic DiseasesDiet, Metabolism, and Disease

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The metabolic syndrome: time to get off the merry-go-round?: Review: The metabolic syndrome

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Reaven, G. M.·2011·Journal of Internal Medicine

DOI 10.1111/j.1365-2796.2010.02325.x

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Abstract

The diagnostic category of the metabolic syndrome (MetS) has received considerable attention over the last decade, and prestigious organizations continue to strive for its incorporation into medical practice. This review has three goals: (i) summarize the history of the several attempts to define a diagnostic category designated as the MetS; (ii) question the aetiological role of abdominal obesity in the development of the other components of the MetS; and (iii) evaluate a diagnosis of the MetS as an effective way to identify apparently healthy individuals at increased risk to develop cardiovascular disease (CVD) or type 2 diabetes (2DM). The most important conclusion is that the MetS seems to be less effective in this population than the Framingham Risk Score in predicting CVD, and no better, if not worse, than fasting plasma glucose concentrations in predicting 2DM.

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Authors: Reaven, G. M.
Affiliations: Stanford Medicine (US)
Corresponding author: Reaven, G. M.
Venue: Journal of Internal Medicine
Publisher: Wiley
Published: 2010-12-03
Volume: 269
Issue: 2
Pages: 127-136
ISSN: 0954-6820 (ISSN-L)
DOI: 10.1111/j.1365-2796.2010.02325.x
OpenAlex: W1492634769
Cited by: 214
References: 46
Citations by year: 2026: 6 · 2025: 10 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 11 · 2020: 8 · 2019: 12 · 2018: 11 · 2017: 19 · 2016: 19 · 2015: 14 · 2014: 27 · 2013: 17 · 2012: 34
FWCI: 2.98
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1733 d)
Locations: Journal of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: metabolic syndrome, diagnostic criteria, abdominal obesity, cardiovascular risk, type 2 diabetes, Framingham risk score, fasting blood glucose, risk prediction, etiology
MeSH terms: Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Risk Assessment, Metabolic Syndrome, Obesity, Abdominal

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