Clues from Bariatric Surgery: Reversing Insulin Resistance to Heal the Heart
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Obesity is a state of metabolic dysregulation of the whole organism and a major contributing factor to the epidemic of insulin resistant diabetes. The nonpharmacologic treatment of obesity with bariatric surgery results in a dramatic and almost instantaneous reversal of insulin resistance. The present review collectively addresses the evidence for this phenomenon in the literature and discusses potential metabolic and neurohumoral mechanisms. We propose that nutrient restriction lowers the cell's defense mechanisms for nutrient overload in insulin responsive organs.
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Reversal of insulin resistance after bariatric surgery is induced before any significant weight loss occurs.
“The improvements observed in post-surgery were originally postulated to be induced by the subsequent post-surgery weight loss, but it has become apparent that reversal of insulin resistance is induced before any significant weight loss occurs.298”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [298]
It is currently unclear how T2D remission is achieved via bariatric surgery, but it is not just due to the weight loss associated with this surgery.
“Hence, it is currently unclear how T2D remission is achieved via bariatric surgery, but it is not just due to the weight loss associated with this surgery.”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [298]
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Reed, J., Bain, S., & Kanamarlapudi, V. (2021) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s319895 · Cited by 441 · see citing works
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- Authors
- Khalaf, K. I., & Taegtmeyer, H.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Corresponding author
- Taegtmeyer, Heinrich
- ORCID
- Taegtmeyer, Heinrich
- Venue
- Current Diabetes Reports
- Published
- 2013-01-26
- Volume
- 13
- Issue
- 2
- Pages
- 245-251
- ISSN
- 1534-4827 (ISSN-L)
- 1539-0829
- PMC
- PMC3595325
- OpenAlex
- W2156619378
- Cited by
- 13
- References
- 55
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2015: 1 · 2013: 1
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Diabetes Reports (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL061483, R01HL073162)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- bariatric surgery, insulin resistance, obesity, type 2 diabetes, metabolic surgery, nutrient restriction, cardioprotection, neurohumoral mechanisms, metabolic dysfunction
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Obesity, Bariatric Surgery
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