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Differential Localization of Estrogen Receptors in Various Vasopressin Synthesizing Nuclei of the Rat Brain
Open accessAbstract
Vasopressin (VP) cells in the bed nucleus of the stria terminalis, medial amygdaloid nucleus and supraoptic and paraventricular nuclei are influenced by gonadal steroids. The present paper examined whether VP cells in the bed nucleus of the stria terminalis, medial amygdaloid nucleus, and supraoptic and paraventricular nuclei contain estrogen receptors. Brains from adult short‐term castrated, colchicine‐treated male rats were fixed with 4% paraformaldehyde and 0.5% glutaraldehyde. In the immunocytochemical double‐staining procedure Vibratome sections were first incubated with an estrogen receptor antibody (#H222) and stained with diaminobenzidine‐Ni+. Following methanol‐hydrogen peroxide washes, sections were incubated with anti‐neurophysin and stained with diaminobenzidine. Parvocellular cells in the bed nucleus of the stria terminalis and medial amygdaloid nucleus were double‐stained with a blue‐black nucleus (indicating the estrogen receptors) surrounded by brown cytoplasm (resulting from VP‐neurophysin‐immunoreactivity). Our results provide the first direct anatomical evidence supporting the hypothesis that gonadal steroids' influence of parvocellular VP cells in the bed nucleus of the stria terminalis and medial amygdaloid nucleus is mediated directly via estrogen receptors localized in nuclei of VP neurons. We were unable to co‐localize any estrogen receptors in VP and oxytocin cells of magnocellular size in the supraoptic, paraventricular and anterior commissural nuclei, suggesting that estrogen indirectly affects these magnocellular hypothalamic cells.
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“since virtually all them are immunoreactive for androgen and estrogen receptors (Axelson and Van Leeuwen, 1990;Zhou et al., 1993).”
From Sex differences in the effects of testosterone and its metabolites on vasopressin messenger RNA levels in the bed nucleus of the stria terminalis of rats (1994) · cites this paper as Axelson and Van Leeuwen, 1990
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Cites
Atlas of estradiol‐concentrating cells in the central nervous system of the female rat
Pfaff, D. W., & Keiner, M. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901510204 · Cited by 1,494
Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells
King, W. J., & Greene, G. L. (1984) · Nature · doi:10.1038/307745a0 · Cited by 1,408
Holmes, R. L. (1982) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(82)90255-3 · Cited by 567
Rhodes, C. H., Morriell, J. I., & Pfaff, D. W. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901980106 · Cited by 536
Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurones
Shivers, B. D., Harlan, R. E., Morrell, J. I., & Pfaff, D. W. (1983) · Nature · doi:10.1038/304345a0 · Cited by 531
The vasopressinergic innervation of the brain in normal and castrated rats
DeVries, G. J., Buijs, R. M., van Leeuwen, F. W., Caffé, A. R., & Swaab, D. F. (1985) · Journal of Comparative Neurology · doi:10.1002/cne.902330206 · Cited by 522
Streefkerk, J. G. (1972) · Journal of Histochemistry & Cytochemistry · doi:10.1177/20.10.829 · Cited by 363
Estradiol-Concentrating Neurons: Topography in the Hypothalamus by Dry-Mount Autoradiography
Stumpf, W. E. (1968) · Science · doi:10.1126/science.162.3857.1001 · Cited by 298
van Leeuwen, F. W., Caffe, A. R., & Vries, G. J. D. (1985) · Brain Research · doi:10.1016/0006-8993(85)90348-8 · Cited by 248
Flügge, G., Oertel, W. H., & Wuttke, W. (2008) · Neuroendocrinology · doi:10.1159/000124500 · Cited by 238
Research works printed but not linked: 2
- Vries GJ, 1984, Sex differences in the brain. Progress in Brain Research, 23
- Leeuwen FW, 1987, Neuromethods, 73
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Ontogeny of arginine vasopressin-like immunoreactivity in the Brazilian opossum brain
Iqbal, J., & Jacobson, C. D. (1995) · Developmental Brain Research · doi:10.1016/0165-3806(95)00097-w · Cited by 18
Watson, R. E., Hutchinson, R. K., Langub, M. C., Landis, J. W., Seksaria, S., Rainey, D., & KEIL, L. C. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00557.x · Cited by 18
Gender‐related changes in the avian vasotocin system during ontogeny
Jurkevich, A., Großmann, R., Balthazart, J., & Viglietti‐Panzica, C. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1153 · Cited by 17
Seredynski, A. L., Ball, G. F., Balthazart, J., & Charlier, T. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018627 · Cited by 16
Chapter 5 Central vasopressin systems and steroid hormones
Kalsbeek, A., Palmand, I. F., & Buijs, R. M. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39007-1 · Cited by 16
Whorf, R. C., & Tobet, S. A. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230202 · Cited by 15
Regulation of Galanin in Memory Pathways
MILLER, M. A. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10705.x · Cited by 14
MILLER, M. A., Ferris, C. F., & Kolb, P. E. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00029-7 · Cited by 14
Kalamarz‐Kubiak, H., Gozdowska, M., Guellard, T., & Kulczykowska, E. (2017) · Biology Open · doi:10.1242/bio.024844 · Cited by 12
van Zwieten, E. J., Kos, W., Ravid, R., & Swaab, D. F. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90008-y · Cited by 11
Garcia, A. N., Depena, C., Bezner, K. S., Yin, W., & Gore, A. C. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.10.018 · Cited by 11
Silverman, A., DonCarlos, L. L., & Morrell, J. I. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00327.x · Cited by 11
Embryonic differentiation of sexual dimorphism in vasotocin and mesotocin levels in chickens
Robinzon, B., Sayag, N., Koike, T. I., Kinzler, S. L., & Marks, P. A. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90036-f · Cited by 11
Amygdala AVPR1A mediates susceptibility to chronic social isolation in female mice
François, M., Vranich, K. A., Delgado, I. C., Lafond, A., Lopatinsky, N. R., Davis, T., Lewis, E. M., Kuromaru, M., Hassouna, R., Williams, B. L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64742-y · Cited by 11
Swaab, D. F., Goudsmit, E., Kremer, H. P. H., Hofman, M. A., & Ravid, R. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)62369-9 · Cited by 10
Neuroplasticity and Aggression: An Interaction Between Vasopressin and Serotonin
Ferris, C. F. (2005) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195168761.003.0007 · Cited by 10
Dufourny, L., Warembourg, M., & Jolivet, A. (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00190.x · Cited by 10
Hypothalamic Transcription Factors and the Regulation of the Hypothalamo-Neurohypophysial System
Burbach, J. P. H., van Schaick, H. S. A., da Silva, S. L., Asbreuk, C. H. J., & Smidt, M. P. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4871-3_3 · Cited by 9
Burbach, J. P. H., Burbach, H., & Adan, R. A. H. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb55535.x · Cited by 9
Vasopressin and Oxytocin Receptors and the Developing Brain
Boer, G. J. (1993) · Springer eBooks · doi:10.1007/978-94-011-1540-7_12 · Cited by 9
Caffe´, A. R., Holstege, J. C., & van Leeuwen, F. W. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63812-1 · Cited by 4
Ren, S., Wang, X., Huang, X., Chen, L., Zhang, B., Li, Y., & Huang, X. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01272-9 · Cited by 3
Cruttwell, C., Herbison, A. E., & Bicknell, R. J. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12075-f · Cited by 3
Aoyama, M., Takeuchi, Y., Mori, Y., & OKAMURA, H. (1998) · Journal of Reproduction and Development · doi:10.1262/jrd.44.149 · Cited by 3
Dufourny, L., & Warembourg, M. (2001) · Experimental Brain Research · doi:10.1007/s002210000569 · Cited by 2
Neuroendocrine Changes in Aging and Alzheimer’s Disease
Swaab, D. F., Goudsmit, E., Kremer, H. P. H., Ravid, R., & Witting, W. (1992) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4684-6805-2_13
Sex Differences in Neurotransmitters Systems; Vasopressin as an Example
Vries, G. J. D. (2006) · Springer eBooks · doi:10.1007/978-0-387-30405-2_12
Iqbal, J. (1995) · Iowa State University Digital Repository (Iowa State University) · doi:10.31274/rtd-180813-10084
Steroid Sensitive Neurons and Male Rat Mating Behavior
Huddleston, G. G. (2022) · Digital Archive @ GSU · doi:10.57709/1063847
Circuits neuronaux sous-tendant la régulation émotionnelle par le système ocytocinergique
Goyon, S. (2018) · theses.fr (ABES) · doi:10.70675/c8c9bec0z7b79z4826z862az93b128e1ada6
Wang (1997) · doi:10.1002/(sici)1098-2396(199709)27:1
Metadata
- Authors
- Axelson, J. F., & van Leeuwen, F. W.
- Affiliations
- College of the Holy Cross (US)
- Corresponding author
- van Leeuwen, Fred W.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 1990-04
- Volume
- 2
- Issue
- 2
- Pages
- 209-216
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2069085535
- Cited by
- 133
- References
- 42
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2018: 1 · 2017: 2 · 2013: 1
- FWCI
- 27.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Jan Dekker Stichting
- National Institutes of Health (5r01am016166-12)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- estrogen receptor, vasopressin neurons, bed nucleus of the stria terminalis, medial amygdala, supraoptic nucleus, paraventricular nucleus, neurophysin, parvocellular neurons, magnocellular neurons, oxytocin, hypothalamus, castration, colchicine
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