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Differential Localization of Estrogen Receptors in Various Vasopressin Synthesizing Nuclei of the Rat Brain
Open accessAbstract
Vasopressin (VP) cells in the bed nucleus of the stria terminalis, medial amygdaloid nucleus and supraoptic and paraventricular nuclei are influenced by gonadal steroids. The present paper examined whether VP cells in the bed nucleus of the stria terminalis, medial amygdaloid nucleus, and supraoptic and paraventricular nuclei contain estrogen receptors. Brains from adult short‐term castrated, colchicine‐treated male rats were fixed with 4% paraformaldehyde and 0.5% glutaraldehyde. In the immunocytochemical double‐staining procedure Vibratome sections were first incubated with an estrogen receptor antibody (#H222) and stained with diaminobenzidine‐Ni+. Following methanol‐hydrogen peroxide washes, sections were incubated with anti‐neurophysin and stained with diaminobenzidine. Parvocellular cells in the bed nucleus of the stria terminalis and medial amygdaloid nucleus were double‐stained with a blue‐black nucleus (indicating the estrogen receptors) surrounded by brown cytoplasm (resulting from VP‐neurophysin‐immunoreactivity). Our results provide the first direct anatomical evidence supporting the hypothesis that gonadal steroids' influence of parvocellular VP cells in the bed nucleus of the stria terminalis and medial amygdaloid nucleus is mediated directly via estrogen receptors localized in nuclei of VP neurons. We were unable to co‐localize any estrogen receptors in VP and oxytocin cells of magnocellular size in the supraoptic, paraventricular and anterior commissural nuclei, suggesting that estrogen indirectly affects these magnocellular hypothalamic cells.
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“since virtually all them are immunoreactive for androgen and estrogen receptors (Axelson and Van Leeuwen, 1990;Zhou et al., 1993).”
From Sex differences in the effects of testosterone and its metabolites on vasopressin messenger RNA levels in the bed nucleus of the stria terminalis of rats (1994) · cites this paper as Axelson and Van Leeuwen, 1990
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Cites
Atlas of estradiol‐concentrating cells in the central nervous system of the female rat
Pfaff, D. W., & Keiner, M. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901510204 · Cited by 1,494
Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells
King, W. J., & Greene, G. L. (1984) · Nature · doi:10.1038/307745a0 · Cited by 1,408
Holmes, R. L. (1982) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(82)90255-3 · Cited by 567
Rhodes, C. H., Morriell, J. I., & Pfaff, D. W. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901980106 · Cited by 536
Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurones
Shivers, B. D., Harlan, R. E., Morrell, J. I., & Pfaff, D. W. (1983) · Nature · doi:10.1038/304345a0 · Cited by 531
The vasopressinergic innervation of the brain in normal and castrated rats
DeVries, G. J., Buijs, R. M., van Leeuwen, F. W., Caffé, A. R., & Swaab, D. F. (1985) · Journal of Comparative Neurology · doi:10.1002/cne.902330206 · Cited by 522
Streefkerk, J. G. (1972) · Journal of Histochemistry & Cytochemistry · doi:10.1177/20.10.829 · Cited by 363
Estradiol-Concentrating Neurons: Topography in the Hypothalamus by Dry-Mount Autoradiography
Stumpf, W. E. (1968) · Science · doi:10.1126/science.162.3857.1001 · Cited by 298
van Leeuwen, F. W., Caffe, A. R., & Vries, G. J. D. (1985) · Brain Research · doi:10.1016/0006-8993(85)90348-8 · Cited by 248
Flügge, G., Oertel, W. H., & Wuttke, W. (2008) · Neuroendocrinology · doi:10.1159/000124500 · Cited by 238
Gonadal hormone actions on the morphology of the vasopressinergic innervation of the adult rat brain
De Vries, G. J., Buijs, R. M., & Sluiter, A. A. (1984) · Brain Research · doi:10.1016/0006-8993(84)91157-0 · Cited by 224
Vasopressin-immunoreactive cell bodies in the bed nucleus of the stria terminalis of the rat
van Leeuwen, F., & Caffé, R. (1983) · Cell and Tissue Research · doi:10.1007/bf00211473 · Cited by 206
Caffe´, A. R., & van Leeuwen, F. W. (1983) · Cell and Tissue Research · doi:10.1007/bf00222229 · Cited by 199
Morrell, J. I., McGinty, J. F., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000124212 · Cited by 166
Cintra, A., Fuxé, K., Härfstrand, A., Agnati, L. F., Miller, L. S., Greene, J. L., & Gustafsson, J.-Α. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90196-8 · Cited by 166
Warembourg, M., Jolivet, A., & Milgröm, E. (1989) · Brain Research · doi:10.1016/0006-8993(89)91561-8 · Cited by 165
Effects of Sex Steroid Hormones on Arginine Vasopressin in Intact and Castrated Male and Female Rats
Skowsky, R., Swan, L., & Smith, P. B. W. (1979) · Endocrinology · doi:10.1210/endo-104-1-105 · Cited by 160
De Vries, G. J., Duetz, W., Buijs, R. M., van Heerikhuize, J., & Vreeburg, J. T. M. (1986) · Brain Research · doi:10.1016/0006-8993(86)91519-2 · Cited by 153
DIFFUSION ARTIFACTS IN 3,3'-DIAMINOBENZIDINE CYTOCHEMISTRY
Novikoff, A. B., Novikoff, P. M., Quintana, N., & DAVIS, C. (1972) · Journal of Histochemistry & Cytochemistry · doi:10.1177/20.9.745 · Cited by 151
Uhl, G. R., Zingg, H. H., & Habener, J. F. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.16.5555 · Cited by 150
Vasopressin and oxytocin systems in the brain and upper spinal cord of Macaca fascicularis
Caffé, A. R., Van Ryen, P. C., Van Der Woude, T. P., & Van Leeuwen, F. W. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902870304 · Cited by 128
Estradiol influences oxytocin-immunoreactive brain systems
Jirikowski, G. F., Caldwell, J. D., Pedersen, C. A., & Stumpf, W. E. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90022-x · Cited by 111
Sheridan, P. J. (1979) · Endocrinology · doi:10.1210/endo-104-1-130 · Cited by 105
Sar, M., & Parikh, I. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90111-1 · Cited by 103
The supraoptic nucleus: Afferents from areas involved in control of body fluid homeostasis
Wilkin, L. D., Mitchell, L. D., Ganten, D., & Johnson, A. K. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90006-7 · Cited by 100
Rhodes, C. H., Morrell, J. I., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000123195 · Cited by 96
Kelly, J. P., & Swanson, L. W. (1980) · Brain Research · doi:10.1016/0006-8993(80)90430-8 · Cited by 96
Regulation of neuronal oxytocin mRNA by ovarian steroids in the mature and developing hypothalamus.
Miller, F. D., Ozimek, G., Milner, R. J., & Bloom, F. E. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2468 · Cited by 95
Sar, M., & Stumpf, W. E. (1980) · Neuroscience Letters · doi:10.1016/0304-3940(80)90081-6 · Cited by 93
Mapping of estrogen receptor-producing cells in the rat brain by in situ hybridization
Pelletier, G., Liao, N., Folléa, N., & Govindan, M. V. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90264-9 · Cited by 90
Crowley, W. R., O'Donohue, T. L., George, J. M., & Jacobowitz, D. M. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90373-9 · Cited by 88
Akesson, T. R., & Micevych, P. E. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490190405 · Cited by 86
Rhodes, C., Morrell, J., & Pfaff, D. W. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-12-01718.1982 · Cited by 86
Crofton, J. T., Baer, P. G., Share, L., & Brooks, D. P. (1985) · Endocrinology · doi:10.1210/endo-117-3-1195 · Cited by 85
Rhodes, C. H., Morrell, J. I., & Pfaff, D. W. (1981) · Cell and Tissue Research · doi:10.1007/bf00234544 · Cited by 57
Axonal projections and peptide content of steroid hormone concentrating neurons
Morrell, J. I., Schwanzel‐Fukuda, M., Fahrbach, S. E., & Pfaff, D. W. (1984) · Peptides · doi:10.1016/0196-9781(84)90281-x · Cited by 48
Swaab, D. F., & Jongkind, J. F. (2008) · Neuroendocrinology · doi:10.1159/000121916 · Cited by 47
Shivers, B. D., Harlan, R. E., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000125086 · Cited by 42
A way in which estradiol might play a role in the sexual behavior of male rats
Södersten, P. (1980) · Hormones and Behavior · doi:10.1016/0018-506x(80)90035-5 · Cited by 37
Sar, M., & Stumpf, W. E. (1981) · Journal of Histochemistry & Cytochemistry · doi:10.1177/29.1a_suppl.6895229 · Cited by 36
Akesson, T. R., & Micevych, P. E. (1988) · Journal of Neurobiology · doi:10.1002/neu.480190103 · Cited by 31
Marchetti, P., Sica, G., Natoli, C., Spina, M. A., & Iacobelli, S. (1984) · Springer eBooks · doi:10.1007/978-1-4757-1577-4_10 · Cited by 19
Research works printed but not linked: 2
- Vries GJ, 1984, Sex differences in the brain. Progress in Brain Research, 23
- Leeuwen FW, 1987, Neuromethods, 73
Cited by
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The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Neuroendocrine perspectives on social attachment and love
Sue Carter, C. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00055-9 · Cited by 1,425
Insel, T. R. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90073-g · Cited by 487
Gene Regulation in the Magnocellular Hypothalamo-Neurohypophysial System
Burbach, J. P. H., Luckman, S. M., Murphy, D., & Gainer, H. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1197 · Cited by 344
Herbison, A. E., & Theodosis, D. T. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90423-y · Cited by 283
Metadata
- Authors
- Axelson, J. F., & van Leeuwen, F. W.
- Affiliations
- College of the Holy Cross (US)
- Corresponding author
- van Leeuwen, Fred W.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 1990-04
- Volume
- 2
- Issue
- 2
- Pages
- 209-216
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2069085535
- Cited by
- 133
- References
- 42
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2018: 1 · 2017: 2 · 2013: 1
- FWCI
- 27.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Jan Dekker Stichting
- National Institutes of Health (5r01am016166-12)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- estrogen receptor, vasopressin neurons, bed nucleus of the stria terminalis, medial amygdala, supraoptic nucleus, paraventricular nucleus, neurophysin, parvocellular neurons, magnocellular neurons, oxytocin, hypothalamus, castration, colchicine
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