The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Brain Oxytocin: A Key Regulator of Emotional and Social Behaviours in Both Females and Males
Abstract
In addition to various reproductive stimuli, the neuropeptide oxytocin (OXT) is released both from the neurohypophysial terminal into the blood stream and within distinct brain regions in response to stressful or social stimuli. Brain OXT receptor‐mediated actions were shown to be significantly involved in the regulation of a variety of behaviours. Here, complementary methodological approaches are discussed which were utilised to reveal, for example, anxiolytic and anti‐stress effects of OXT, both in females and in males, effects that were localised within the central amygdala and the hypothalamic paraventricular nucleus. Also, in male rats, activation of the brain OXT system is essential for the regulation of sexual behaviour, and increased OXT system activity during mating is directly linked to an attenuated anxiety‐related behaviour. Moreover, in late pregnancy and during lactation, central OXT is involved in the establishment and fine‐tuned maintenance of maternal care and maternal aggression. In monogamous prairie voles, brain OXT is important for mating‐induced pair bonding, especially in females. Another example of behavioural actions of intracerebral OXT is the promotion of social memory processes and recognition of con‐specifics, as revealed in rats, mice, sheep and voles. Experimental evidence suggests that, in humans, brain OXT exerts similar behavioural effects. Thus, the brain OXT system seems to be a potential target for the development of therapeutics to treat anxiety‐ and depression‐related diseases or abnormal social behaviours including autism.
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In the citing paper
“Social behaviour is governed by OXT in both humans and animals (Bosch and Young, 2018; Menon and Neumann, 2023; Neumann, 2008).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Neumann, 2008
In the citing paper
“Intranasal oxytocin, for instance, has been found to facilitate social function, including improving social memory, memory of facial expressions and identity, enhancing the recognition of mental states revealed by facial expression, probably by causing selective fixation on the eye region when viewing faces, and increasing manifestations of trust (for a review, see Neumann, 2008).”
From A developmental, mentalization-based approach to the understanding and treatment of borderline personality disorder (2009) · cites this paper as Neumann, 2008
In the citing paper
“Moreover, they have also been shown to inhibit other behavioral systems that are involved in resilience, such as exploration, affiliation, and caregiving (Insel & Young, 2001; Mikulincer & Shaver, 2007; Neumann, 2008), which might also partially explain these individuals' difficulties in entering lasting relationships (including relationships with mental health care professionals) and the”
From A developmental, mentalization-based approach to the understanding and treatment of borderline personality disorder (2009) · cites this paper as Neumann, 2008
In the citing paper
“In addition, as parents experience higher stress over the first 6 months of parenting (48,49), OT activity may increase to mediate such parenting stress (16,49,50).”
From Oxytocin and the development of parenting in humans (2010) · cites this paper as [49]
In the citing paper
“This conceptualization is consistent with the known anxiolytic effects of OT on internal state and social behavior (61).”
From Oxytocin administration to parent enhances infant physiological and behavioral readiness for social engagement (2012) · cites this paper as [61]
In the citing paper
“our results agree with previous works showing that either intraperitoneally or intracerebroventricularly acutely-injected OXT facilitate reproductive and sociosexual behaviors in male rodents (Arletti et al, 1985;Neumann, 2008;Witt, 1995).”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Neumann, 2008
Citations
Cites
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
Self-citationOxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M., Swaab, D. F., Dogterom, J., & van Leeuwen, F. W. (1978) · Cell and Tissue Research · doi:10.1007/bf00224932 · Cited by 1,029
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945
Pedersen, C. A., & Prange, A. J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6661 · Cited by 841
Research works printed but not linked: 3
- Lonstein JS, 2006, Handbook of Neurochemistry and Molecular Biology, 1
- Numan M, 2003, Hormones, Brain, and Behavior Series
- Temple JL, 2003, Disruption of the genes for either oxytocin or the vasopressin 1B receptor alters male‐induced pregnancy block (the Bruce Effect). In: Society for Neuroscience Meeting
Cited by
Sorted by citations
Fonagy, P., & Luyten, P. (2009) · Development and Psychopathology · doi:10.1017/s0954579409990198 · Cited by 1,146
“…improving social memory, memory of facial expressions and identity, enhancing the recognition of mental states revealed by facial expression, probably by causing selective fixation on the eye region when viewing faces, and increasing manifestations of trust (for a review, see Neumann, 2008).”
BackgroundEvoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954
Self-citationThe Neurobiology of Human Attachments
Feldman, R. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.11.007 · Cited by 839
Metadata
- Authors
- Neumann, I. D.
- Affiliations
- University of Regensburg (DE)
- Corresponding author
- Neumann, I. D.
- ORCID
- Neumann, I. D.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2008-06
- Volume
- 20
- Issue
- 6
- Pages
- 858-865
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2039714243
- Semantic Scholar
- 39de7824db1c15f15b99d5947e6c556faef972fc
- Cited by
- 743
- References
- 112
- Citations by year
- 2026: 13 · 2025: 27 · 2024: 27 · 2023: 18 · 2022: 25 · 2021: 47 · 2020: 53 · 2019: 26 · 2018: 44 · 2017: 46 · 2016: 47 · 2015: 56 · 2014: 53 · 2013: 61 · 2012: 53
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin receptor, social behavior, emotional behavior, anxiety, stress, central amygdala, paraventricular nucleus, sexual behavior, maternal care, maternal aggression, pair bonding, Microtus ochrogaster, social memory, autism spectrum disorder, depression
- MeSH terms
- Animals, Behavior, Animal, Brain, Emotions, Female, Male, Maternal Behavior, Oxytocin, Pair Bond, Pregnancy, Social Behavior, Stress, Psychological, Receptors, Oxytocin, Rats
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