Brain oxytocin: A key regulator of emotional and social behaviours in both females and males

Neumann, I. D.

doi:10.1111/j.1365-2826.2008.01726.x

Cited by 743Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Brain oxytocin: A key regulator of emotional and social behaviours in both females and males

Neumann, I. D.·2008·Journal of Neuroendocrinology

DOI 10.1111/j.1365-2826.2008.01726.x

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Abstract

In addition to various reproductive stimuli, the neuropeptide oxytocin (OXT) is released both from the neurohypophysial terminal into the blood stream and within distinct brain regions in response to stressful or social stimuli. Brain OXT receptor‐mediated actions were shown to be significantly involved in the regulation of a variety of behaviours. Here, complementary methodological approaches are discussed which were utilised to reveal, for example, anxiolytic and anti‐stress effects of OXT, both in females and in males, effects that were localised within the central amygdala and the hypothalamic paraventricular nucleus. Also, in male rats, activation of the brain OXT system is essential for the regulation of sexual behaviour, and increased OXT system activity during mating is directly linked to an attenuated anxiety‐related behaviour. Moreover, in late pregnancy and during lactation, central OXT is involved in the establishment and fine‐tuned maintenance of maternal care and maternal aggression. In monogamous prairie voles, brain OXT is important for mating‐induced pair bonding, especially in females. Another example of behavioural actions of intracerebral OXT is the promotion of social memory processes and recognition of con‐specifics, as revealed in rats, mice, sheep and voles. Experimental evidence suggests that, in humans, brain OXT exerts similar behavioural effects. Thus, the brain OXT system seems to be a potential target for the development of therapeutics to treat anxiety‐ and depression‐related diseases or abnormal social behaviours including autism.

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Social behaviour is governed by OXT in both humans and animals.
“Social behaviour is governed by OXT in both humans and animals (Bosch and Young, 2018; Menon and Neumann, 2023; Neumann, 2008).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Neumann, 2008
Intranasal oxytocin facilitates social function, including improving social memory, memory of facial expressions and identity, enhancing recognition of mental states from facial expression, probably by selective fixation on the eye region, and increasing trust.
“Intranasal oxytocin, for instance, has been found to facilitate social function, including improving social memory, memory of facial expressions and identity, enhancing the recognition of mental states revealed by facial expression, probably by causing selective fixation on the eye region when viewing faces, and increasing manifestations of trust (for a review, see Neumann, 2008).”
From A developmental, mentalization-based approach to the understanding and treatment of borderline personality disorder (2009) · cites this paper as Neumann, 2008
Attachment hyperactivation and deactivation strategies have been shown to inhibit other behavioral systems involved in resilience, such as exploration, affiliation, and caregiving, which might partially explain difficulties entering lasting relationships and intergenerational transmission of psychopathology.
“Moreover, they have also been shown to inhibit other behavioral systems that are involved in resilience, such as exploration, affiliation, and caregiving (Insel & Young, 2001; Mikulincer & Shaver, 2007; Neumann, 2008), which might also partially explain these individuals' difficulties in entering lasting relationships (including relationships with mental health care professionals) and the”
From A developmental, mentalization-based approach to the understanding and treatment of borderline personality disorder (2009) · cites this paper as Neumann, 2008
As parents experience higher stress over the first 6 months of parenting, OT activity may increase to mediate such parenting stress.
“In addition, as parents experience higher stress over the first 6 months of parenting (48,49), OT activity may increase to mediate such parenting stress (16,49,50).”
From Oxytocin and the development of parenting in humans (2010) · cites this paper as [49]
Oxytocin has anxiolytic effects on internal state and social behavior.
“This conceptualization is consistent with the known anxiolytic effects of OT on internal state and social behavior (61).”
From Oxytocin administration to parent enhances infant physiological and behavioral readiness for social engagement (2012) · cites this paper as [61]

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Numan M, 2003, Hormones, Brain, and Behavior Series
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Evoked axonal oxytocin release in the central amygdala attenuates fear response
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Integrating theory-driven and empirically-derived models of personality development and psychopathology: A proposal for DSM V
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Authors: Neumann, I. D.
Affiliations: University of Regensburg (DE)
Corresponding author: Neumann, I. D.
ORCID: Neumann, I. D.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2008-06
Volume: 20
Issue: 6
Pages: 858-865
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1111/j.1365-2826.2008.01726.x
OpenAlex: W2039714243
Semantic Scholar: 39de7824db1c15f15b99d5947e6c556faef972fc
Cited by: 743
References: 112
Citations by year: 2026: 13 · 2025: 27 · 2024: 27 · 2023: 18 · 2022: 25 · 2021: 47 · 2020: 53 · 2019: 26 · 2018: 44 · 2017: 46 · 2016: 47 · 2015: 56 · 2014: 53 · 2013: 61 · 2012: 53
FWCI: 6.45
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 39 d)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: oxytocin receptor, social behavior, emotional behavior, anxiety, stress, central amygdala, paraventricular nucleus, sexual behavior, maternal care, maternal aggression, pair bonding, Microtus ochrogaster, social memory, autism spectrum disorder, depression
MeSH terms: Animals, Behavior, Animal, Brain, Emotions, Female, Male, Maternal Behavior, Oxytocin, Pair Bond, Pregnancy, Social Behavior, Stress, Psychological, Receptors, Oxytocin, Rats

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Brain oxytocin: A key regulator of emotional and social behaviours in both females and males

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