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Cited by 208Neuroendocrine regulation and behaviorCardiovascular, Neuropeptides, and Oxidative Stress ResearchNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 100 of the 101 references it cites were found in a registry or an index.

Oxytocin Revisited: Its Role in Cardiovascular Regulation

Gutkowska, J., Jankowski, M.·2012·Journal of Neuroendocrinology
DOI 10.1111/j.1365-2826.2011.02235.x
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Abstract

Traditionally associated with female reproduction, oxytocin (OT) was revisited recently and was revealed to have several new roles in the cardiovascular system. Functional OT receptors have been discovered in the rat and human heart, as well as in vascular beds. The cardiovascular activities of OT include: (i) lowering blood pressure; (ii) negative cardiac inotropy and chronotropy; (iii) parasympathetic neuromodulation; (iv) vasodilatation; (v) anti-inflammatory; (vi) antioxidative; and (vii) metabolic effects. These outcomes are mediated, at least in part, by stimulating cardioprotective mediators, such as nitric oxide and atrial natriuretic peptide. OT and its extended form OT-Gly-Lys-Arg have been shown to be abundant in the foetal mouse heart. OT has the capacity to generate cardiomyocytes from various types of stem cells, including the cardiac side population. Mesenchymal cells transfected with OT-Gly-Lys-Arg, or preconditioned with OT, are resistant to apoptosis and express endothelial cell markers. OT increases glucose uptake in cultured cardiomyocytes from newborn and adult rats, in normal, hypoxic and even insulin resistance conditions. In rats with experimentally-induced myocardial infarction, continuous in vivo OT delivery improves the cardiac healing process, as well as cardiac work, reduces inflammation and stimulates angiogenesis. Therefore, in pathological conditions, OT exerts anti-inflammatory and cardioprotective properties, and improves vascular and metabolic functions. Thus, OT has potential for therapeutic use.

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Research works printed but not linked: 2

  1. DeWardener HE, 1985, Natriuretic Hormone, 1013
  2. 10.1210/en.136.9.4022 · DOI · Paper page

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Metadata

Authors
Gutkowska, J., & Jankowski, M.
Affiliations
Centre Hospitalier de l’Université de Montréal (CA)
Corresponding author
Gutkowska, J.
ORCID
Jankowski, M.
Venue
Journal of Neuroendocrinology
Publisher
Wiley
Published
2012-03-26
Volume
24
Issue
4
Pages
599-608
ISSN
  • 0953-8194 (ISSN-L)
  • 1365-2826
DOI
10.1111/j.1365-2826.2011.02235.x
OpenAlex
W1601819842
Cited by
208
References
101
Citations by year
2026: 5 · 2025: 10 · 2024: 14 · 2023: 17 · 2022: 12 · 2021: 19 · 2020: 12 · 2019: 20 · 2018: 13 · 2017: 16 · 2016: 13 · 2015: 17 · 2014: 18 · 2013: 20 · 2012: 2
FWCI
1.68
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Heart and Stroke Foundation of Canada
  • Canadian Institutes of Health Research
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
oxytocin, cardiovascular regulation, oxytocin receptor, blood pressure, negative inotropic effect, negative chronotropic effect, vasodilation, anti-inflammatory activity, antioxidant activity, nitric oxide, atrial natriuretic peptide, cardiomyocyte differentiation, mesenchymal stem cells, myocardial infarction, angiogenesis, cardioprotection, hypoxia, insulin resistance
MeSH terms
Animals, Cardiovascular System, Cell Differentiation, Disease Models, Animal, Humans, Models, Biological, Myocardial Infarction, Atrial Natriuretic Factor, Oxytocin, Receptors, Oxytocin, Myocytes, Cardiac

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