The DOI matches its Crossref record; 100 of the 101 references it cites were found in a registry or an index.
Oxytocin Revisited: Its Role in Cardiovascular Regulation
Abstract
Traditionally associated with female reproduction, oxytocin (OT) was revisited recently and was revealed to have several new roles in the cardiovascular system. Functional OT receptors have been discovered in the rat and human heart, as well as in vascular beds. The cardiovascular activities of OT include: (i) lowering blood pressure; (ii) negative cardiac inotropy and chronotropy; (iii) parasympathetic neuromodulation; (iv) vasodilatation; (v) anti-inflammatory; (vi) antioxidative; and (vii) metabolic effects. These outcomes are mediated, at least in part, by stimulating cardioprotective mediators, such as nitric oxide and atrial natriuretic peptide. OT and its extended form OT-Gly-Lys-Arg have been shown to be abundant in the foetal mouse heart. OT has the capacity to generate cardiomyocytes from various types of stem cells, including the cardiac side population. Mesenchymal cells transfected with OT-Gly-Lys-Arg, or preconditioned with OT, are resistant to apoptosis and express endothelial cell markers. OT increases glucose uptake in cultured cardiomyocytes from newborn and adult rats, in normal, hypoxic and even insulin resistance conditions. In rats with experimentally-induced myocardial infarction, continuous in vivo OT delivery improves the cardiac healing process, as well as cardiac work, reduces inflammation and stimulates angiogenesis. Therefore, in pathological conditions, OT exerts anti-inflammatory and cardioprotective properties, and improves vascular and metabolic functions. Thus, OT has potential for therapeutic use.
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“Oxytocin receptors are expressed in the heart, coupled to secretion of natriuretic hormone (48).Oxytocin has direct cardiac effects, and intranasal application in man increases heart rate variability (49).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [48]
In the citing paper
“oxytocin has been reported to reduce HR [24]”
In the citing paper
“apart from oxytocin’s undisputed role in cardiovascular regulation [24]”
Citations
Cites
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Cited by
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The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Oxytocin pathways and the evolution of human behavior
Carter, C. S. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115110 · Cited by 714
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Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 616
The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation
Napso, T., Yong, H. E. J., Lopez-Tello, J., & Sferruzzi-Perri, A. N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01091 · Cited by 470
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
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Metadata
- Authors
- Gutkowska, J., & Jankowski, M.
- Affiliations
- Centre Hospitalier de l’Université de Montréal (CA)
- Corresponding author
- Gutkowska, J.
- ORCID
- Jankowski, M.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2012-03-26
- Volume
- 24
- Issue
- 4
- Pages
- 599-608
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W1601819842
- Cited by
- 208
- References
- 101
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 14 · 2023: 17 · 2022: 12 · 2021: 19 · 2020: 12 · 2019: 20 · 2018: 13 · 2017: 16 · 2016: 13 · 2015: 17 · 2014: 18 · 2013: 20 · 2012: 2
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heart and Stroke Foundation of Canada
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, cardiovascular regulation, oxytocin receptor, blood pressure, negative inotropic effect, negative chronotropic effect, vasodilation, anti-inflammatory activity, antioxidant activity, nitric oxide, atrial natriuretic peptide, cardiomyocyte differentiation, mesenchymal stem cells, myocardial infarction, angiogenesis, cardioprotection, hypoxia, insulin resistance
- MeSH terms
- Animals, Cardiovascular System, Cell Differentiation, Disease Models, Animal, Humans, Models, Biological, Myocardial Infarction, Atrial Natriuretic Factor, Oxytocin, Receptors, Oxytocin, Myocytes, Cardiac
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