Cited by 208Neuroendocrine regulation and behaviorCardiovascular, Neuropeptides, and Oxidative Stress ResearchNeuropeptides and Animal Physiology

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Oxytocin Revisited: Its Role in Cardiovascular Regulation

Gutkowska, J., Jankowski, M.·2012·Journal of Neuroendocrinology

DOI 10.1111/j.1365-2826.2011.02235.x

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Abstract

Traditionally associated with female reproduction, oxytocin (OT) was revisited recently and was revealed to have several new roles in the cardiovascular system. Functional OT receptors have been discovered in the rat and human heart, as well as in vascular beds. The cardiovascular activities of OT include: (i) lowering blood pressure; (ii) negative cardiac inotropy and chronotropy; (iii) parasympathetic neuromodulation; (iv) vasodilatation; (v) anti-inflammatory; (vi) antioxidative; and (vii) metabolic effects. These outcomes are mediated, at least in part, by stimulating cardioprotective mediators, such as nitric oxide and atrial natriuretic peptide. OT and its extended form OT-Gly-Lys-Arg have been shown to be abundant in the foetal mouse heart. OT has the capacity to generate cardiomyocytes from various types of stem cells, including the cardiac side population. Mesenchymal cells transfected with OT-Gly-Lys-Arg, or preconditioned with OT, are resistant to apoptosis and express endothelial cell markers. OT increases glucose uptake in cultured cardiomyocytes from newborn and adult rats, in normal, hypoxic and even insulin resistance conditions. In rats with experimentally-induced myocardial infarction, continuous in vivo OT delivery improves the cardiac healing process, as well as cardiac work, reduces inflammation and stimulates angiogenesis. Therefore, in pathological conditions, OT exerts anti-inflammatory and cardioprotective properties, and improves vascular and metabolic functions. Thus, OT has potential for therapeutic use.

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Authors: Gutkowska, J., & Jankowski, M.
Affiliations: Centre Hospitalier de l’Université de Montréal (CA)
Corresponding author: Gutkowska, J.
ORCID: Jankowski, M.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2012-03-26
Volume: 24
Issue: 4
Pages: 599-608
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1111/j.1365-2826.2011.02235.x
OpenAlex: W1601819842
Cited by: 208
References: 101
Citations by year: 2026: 5 · 2025: 10 · 2024: 14 · 2023: 17 · 2022: 12 · 2021: 19 · 2020: 12 · 2019: 20 · 2018: 13 · 2017: 16 · 2016: 13 · 2015: 17 · 2014: 18 · 2013: 20 · 2012: 2
FWCI: 1.68
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Heart and Stroke Foundation of Canada
Canadian Institutes of Health Research
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, cardiovascular regulation, oxytocin receptor, blood pressure, negative inotropic effect, negative chronotropic effect, vasodilation, anti-inflammatory activity, antioxidant activity, nitric oxide, atrial natriuretic peptide, cardiomyocyte differentiation, mesenchymal stem cells, myocardial infarction, angiogenesis, cardioprotection, hypoxia, insulin resistance
MeSH terms: Animals, Cardiovascular System, Cell Differentiation, Disease Models, Animal, Humans, Models, Biological, Myocardial Infarction, Atrial Natriuretic Factor, Oxytocin, Receptors, Oxytocin, Myocytes, Cardiac

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Oxytocin Revisited: Its Role in Cardiovascular Regulation

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