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Cited by 66Neuroendocrine regulation and behaviorCardiovascular, Neuropeptides, and Oxidative Stress ResearchNeuropeptides and Animal Physiology

Oxytocin may have a therapeutical potential against cardiovascular disease. Possible pharmaceutical and behavioral approaches

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Buemann, Benjamin, Uvnäs-Moberg, Kerstin·2020·Medical Hypotheses
DOI 10.1016/j.mehy.2020.109597
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Abstract

Based on the ancient role of oxytocin and its homologues as amplifiers of reproduction we argue for an evolutionary coupling of oxytocin to signaling pathway which support restorative mechanisms of cells and tissue. In particular, the survival and function of different categories of stem cells and primordial cells are enhanced by mitogen-activated protein kinase (MAPK) pathways. Furthermore, oxytocin stimulates the AMP-activated protein kinase pathway (AMPK) in numerous of cell types which promotes the maintenance of different cell structures. This involves autophagic processes and, in particular, may support the renewal of mitochondria. Mitochondrial fitness may protect against oxidative and inflammatory stress - a well-documented effect of oxytocin. The combined specific trophic and protective effects oxytocin may delay several degenerative phenomena including sarcopenia, type-2 diabetes and atherosclerosis. These effects may be exerted both on a central level supporting the function and integrity of the hypothalamus and peripherally acting directly on blood vessels, pancreas, heart, skeletal muscles and adipose tissue etc. Furthermore, in the capacity of being both a hormone and neuromodulator, oxytocin interacts with numerous of regulatory mechanisms particularly the autonomic nervous system and HPA-axis which may reduce blood pressure and affect the immune function. The potential of the oxytocin system as a behavioral and molecular target for the prevention and treatment of cardiovascular disease is discussed. Focus is put on the affiliative and sexual significance and the different options and limitations associated with a pharmaceutical approach. MeSH: Aging, Atherosclerosis, Heart, Hypothalamus, Inflammation, Love, Orgasm, Oxytocin.

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  • Oxytocin stimulates the activity of the immune system, e.g., T cells.

    “Oxytocin also stimulates the activity of the immune system, e.g., T cells (Buemann and Uvnäs-Moberg, 2020).”

    From The Oxytocinergic System as a Mediator of Anti-stress and Instorative Effects Induced by Nature: The Calm and Connection Theory (2021) · cites this paper as Buemann and Uvnäs-Moberg, 2020

    The section on inflammatory stress describes oxytocin affecting immune responses, including reduced TNF-α secretion by macrophages. It does not report stimulation of immune-system activity or T-cell activity; the effects it describes are predominantly anti-inflammatory (page not provided in our copy). (LLM, conf=0.83)

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Buemann, B., & Uvnäs-Moberg, K.
Corresponding author
Buemann, Benjamin
ORCID
Buemann, Benjamin
Venue
Medical Hypotheses
Publisher
Elsevier BV
Published
2020-05
Volume
138
Pages
109597
ISSN
0306-9877 (ISSN-L)
DOI
10.1016/j.mehy.2020.109597
OpenAlex
W3001907526
Cited by
66
References
30
Citations by year
2026: 4 · 2025: 6 · 2024: 14 · 2023: 13 · 2022: 10 · 2021: 10 · 2020: 9
FWCI
11.48
Type
journal article
Language
en
Open access
Licence
Locations
  • Medical Hypotheses (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences)) (submittedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
oxytocin, cardiovascular disease, atherosclerosis, MAPK signaling, AMPK, autophagy, mitochondrial biogenesis, oxidative stress, inflammation, hypothalamus, autonomic nervous system, hypothalamic-pituitary-adrenal axis, stem cells, type 2 diabetes, sarcopenia, oxytocin analogues, oxytocin therapy
MeSH terms
Cardiovascular Diseases, Pharmaceutical Preparations, Humans, Hypothalamus, Oxytocin, Sarcopenia

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