The DOI matches its Crossref record.
Signal transduction and gene regulation through the phosphorylation of two regulatory components: the molecular basis for the osmotic regulation of the porin genes
Abstract
Summary: Expression of Escherichia coli outer‐membrane porin proteins (OmpF and OmpC) is regulated by the osmolarity of the medium. EnvZ and OmpR, which are positive regulatory factors for the transcriptional osmotic regulation of the ompF and ompC genes, belong to a group of two‐component regulatory factors that respond to a variety of environmental stimuli in bacteria. EnvZ‐OmpR phosphotransfer was revealed to be involved in signal transduction in response to an osmotic stimulus, and to play a crucial physiological role in the consequent osmotic activation of the porin genes. Based on the various lines of experimental evidence, a model is proposed for the molecular mechanism underlying the osmotic regulation through phosphorylation of the activator (OmpR) by the membrane‐locate kinase (EnvZ).
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Cited by
Signal transduction schemes of bacteria
Parkinson, J. S. (1993) · Cell · doi:10.1016/0092-8674(93)90267-t · Cited by 772
Miyakawa, H., Woo, S. K., Dahl, S. C., Handler, J. S., & Kwon, H. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2538 · Cited by 580
Control of Cardiac Gene Expression by Mechanical Stress
Komuro, I., & Yazaki, Y. (1993) · Annual Review of Physiology · doi:10.1146/annurev.ph.55.030193.000415 · Cited by 355
Mojica, F. J. M., Juez, G., & Rodriguez‐Valera, F. (1993) · Molecular Microbiology · doi:10.1111/j.1365-2958.1993.tb01721.x · Cited by 349
Porins and specific channels of bacterial outer membranes
Nikaido, H. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb01487.x · Cited by 340
Metadata
- Authors
- Mizuno, T., & Mizushima, S.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1990-07
- Volume
- 4
- Issue
- 7
- Pages
- 1077-1082
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2080359179
- Cited by
- 228
- References
- 0
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Signal transduction and gene regulation through the phosphorylation of two regulatory components: the molecular basis for the osmotic regulation of the porin genes. https://app.cochat.ai/papers/10.1111/j.1365-2958.1990.tb00681.x
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- Mizuno, T., & Mizushima, S. (1990). Signal transduction and gene regulation through the phosphorylation of two regulatory components: the molecular basis for the osmotic regulation of the porin genes. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.1990.tb00681.x
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