Nitrate regulation of anaerobic respiratory gene expression in Escherichia coli

Stewart, Valley

doi:10.1111/j.1365-2958.1993.tb01704.x

Cited by 176Bacterial Genetics and BiotechnologyEscherichia coli research studiesFungal and yeast genetics research

Nitrate regulation of anaerobic respiratory gene expression in Escherichia coli

Stewart, Valley·1993·Molecular Microbiology

DOI 10.1111/j.1365-2958.1993.tb01704.x

Open this paper in CoChat — free account

Abstract

Synthesis of most anaerobic respiratory pathways is subject to dual regulation by anaerobiosis and nitrate. Anaerobic induction is mediated by the FNR protein. Dual interacting two-component regulatory systems mediate nitrate induction and repression. The response regulator protein NARL binds DNA to control nitrate induction and repression of genes encoding nitrate respiration enzymes and alternate anaerobic respiratory enzymes, respectively. The homologous protein NARP controls nitrite induction of at least two operons. Nitrate and nitrite signalling are both mediated by the homologous sensor proteins NARX and NARQ. Recent mutational analyses have defined a heptamer sequence necessary for specific DNA binding by the NARL protein. These heptamers are located at different positions in the control regions of different operons. The NARL protein-binding sites in the narG (nitrate reductase) and narK (nitrate-nitrite antiporter) operon control regions are located approximately 200bp upstream of the transcription initiation site. The integration host factor (IHF) greatly stimulates nitrate induction of these operons, indicating that a specific DNA loop brings NARL protein, bound at the upstream region, into the proximity of the promoter for transcription activation. Other NARL protein-dependent opersons do not require IHF for nitrate induction, and the arrangement of NARL heptamer sequences in these control regions is quite different. This complexity of signal transduction pathways, coupled with the diversity of control region architecture, combine to provide many interesting areas for future investigation. An additional challenge is to determine how or if the FNR and NARL proteins interact to mediate dual positive control of transcription initiation.

Integrity signals

Registry

Crossref · 10.1111/j.1365-2958.1993.tb01704.x

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The DNRA nitrate reductase nap shares some regulatory elements with nar such as the oxygen-dependent FNR.
“Comparatively, while the DNRA nitrate reductase, nap, shares some regulatory elements with nar such as the oxygen-dependent FNR[77,256,261–264]”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [262]

COMMUNICATION MODULES IN BACTERIAL SIGNALING PROTEINS
Parkinson, J. S., & Kofoid, E. (1992) · Annual Review of Genetics · doi:10.1146/annurev.ge.26.120192.000443 · Cited by 1,450 · see citing works
Integration host factor: A protein for all reasons
Friedman, D. I. (1988) · Cell · doi:10.1016/0092-8674(88)90213-9 · Cited by 492 · see citing works
Nitrate respiration in relation to facultative metabolism in enterobacteria
Stewart, V. J. (1988) · Microbiological Reviews · doi:10.1128/mr.52.2.190-232.1988 · Cited by 438 · see citing works
FNR and its role in oxygen-regulated gene expression in Escherichia coli
Spiro, S., & Guest, J. R. (1990) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1990.tb04109.x · Cited by 416 · see citing works
The integration host factor stimulates interaction of RNA polymerase with NIFA, the transcriptional activator for nitrogen fixation operons
Hoover, T. R., Santero, E., Porter, S. C., & Kustu, S. G. (1990) · Cell · doi:10.1016/0092-8674(90)90284-l · Cited by 359 · see citing works
Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12
Rabin, R. S., & Stewart, V. J. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.11.3259-3268.1993 · Cited by 223 · see citing works
RcsA, an unstable positive regulator of capsular polysaccharide synthesis
Stout, V., Torres-Cabassa, A., Maurizi, M. R., Gutnick, D. L., & Gottesman, S. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.5.1738-1747.1991 · Cited by 222 · see citing works
Requirement of Fnr and NarL functions for nitrate reductase expression in Escherichia coli K-12
Stewart, V. J. (1982) · Journal of Bacteriology · doi:10.1128/jb.151.3.1320-1325.1982 · Cited by 177 · see citing works
Role of the RNA polymerase α subunit in transcription activation
Ishihama, A. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb02196.x · Cited by 175 · see citing works
Identification and expression of genes narL and narX of the nar (nitrate reductase) locus in Escherichia coli K-12
Stewart, V. J., & Parales, J. V. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.4.1589-1597.1988 · Cited by 170 · see citing works
Anaerobic regulation of pyruvate formate-lyase from Escherichia coli K-12
Sawers, R. G., & Böck, A. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.11.5330-5336.1988 · Cited by 148 · see citing works
Modular structure of Fix J: homology of the transcriptional activator domain with the ‐35 binding domain of sigma factors
Kahn, D., & Ditta, G. S. (1991) · Molecular Microbiology · doi:10.1111/j.1365-2958.1991.tb00774.x · Cited by 146 · see citing works
Different physiological roles of two independent pathways for nitrite reduction to ammonia by enteric bacteria
Page, L. V., Griffiths, L., & Cole, J. A. (1990) · Archives of Microbiology · doi:10.1007/bf00276530 · Cited by 138 · see citing works
Molecular genetic analysis of FNR‐dependent promoters
Eiglmeier, K., Honoré, N., Iuchi, S., Lin, E. C. C., & Cole, S. T. (1989) · Molecular Microbiology · doi:10.1111/j.1365-2958.1989.tb00236.x · Cited by 133 · see citing works
Oxygen, nitrate, and molybdenum regulation of dmsABC gene expression in Escherichia coli
Cotter, P. A., & Gunsalus, R. P. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.7.3817-3823.1989 · Cited by 126 · see citing works
The narL gene product activates the nitrate reductase operon and represses the fumarate reductase and trimethylamine N-oxide reductase operons in Escherichia coli.
Iuchi, S., & Lin, E. C. C. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.11.3901 · Cited by 117 · see citing works
Role of integration host factor in stimulating transcription from the σ54-dependent nifH promoter
Santero, E., Hoover, T. R., North, A. K., Berger, D. K., Porter, S. C., & Kustu, S. G. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90211-2 · Cited by 109 · see citing works
Fnr mutants that activate gene expression in the presence of oxygen
Kiley, P. J., & Reznikoff, W. S. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.1.16-22.1991 · Cited by 107 · see citing works
Structural genes for nitrate-inducible formate dehydrogenase in Escherichia coli K-12.
Berg, B. L., & Stewart, V. J. (1990) · Genetics · doi:10.1093/genetics/125.4.691 · Cited by 98 · see citing works
Transcriptional control, translation and function of the products of the five open reading frames of the Escherichia coli nir operon
Harborne, N., Griffiths, L., Busby, S. J. W., & Cole, J. A. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb01460.x · Cited by 85 · see citing works
Positive and negative effects of DNA bending on activation of transcription from a distant site
Claveríe‐Martín, F., & Magasanik, B. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90516-m · Cited by 85 · see citing works
Definition of nitrite and nitrate response elements at the anaerobically inducible Escherichia coli nirB promoter: interactions between FNR and NarL
Tyson, K. L., Bell, A. I., Cole, J. A., & Busby, S. J. W. (1993) · Molecular Microbiology · doi:10.1111/j.1365-2958.1993.tb01106.x · Cited by 83 · see citing works
The narK gene product participates in nitrate transport induced in Escherichia coli nitrate‐respiring cells
Noji, S., Nohno, T., Saito, T., & Taniguchi, S. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80906-8 · Cited by 80 · see citing works
Location of sequences in the nar promoter of Escherichia coli required for regulation by Fnr and NarL.
Li, S. F., & DeMoss, J. A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68297-3 · Cited by 80 · see citing works
Either of two functionally redundant sensor proteins, NarX and NarQ, is sufficient for nitrate regulation in Escherichia coli K-12.
Rabin, R. S., & Stewart, V. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8419 · Cited by 79 · see citing works
NarK enhances nitrate uptake and nitrite excretion in Escherichia coli
DeMoss, J. A., & Hsu, P. Y. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.11.3303-3310.1991 · Cited by 79 · see citing works
Activation of the Escherichia coli nitrate reductase (narGHJI) operon by NarL and Fnr requires integration host factor.
Schröder, I., Darie, S., & Gunsalus, R. P. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53999-5 · Cited by 71 · see citing works
Identification and characterization of narQ , a second nitrate sensor for nitrate‐dependent gene regulation in Escherichia coli
Chiang, R. C., Cavicchioli, R., & Gunsalus, R. P. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb01364.x · Cited by 70 · see citing works
Localization of upstream sequence elements required for nitrate and anaerobic induction of fdn (formate dehydrogenase-N) operon expression in Escherichia coli K-12
Li, J., & Stewart, V. J. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.15.4935-4942.1992 · Cited by 69 · see citing works
Nitrate- and molybdenum-independent signal transduction mutations in narX that alter regulation of anaerobic respiratory genes in Escherichia coli
Kalman, L. V., & Gunsalus, R. P. (1990) · Journal of Bacteriology · doi:10.1128/jb.172.12.7049-7056.1990 · Cited by 65 · see citing works
Regulation of the nitrate reductase operon: Effect of mutations in chl A, B, D and E genes
Pascal, M., Burini, J.-F., Ratouchniak, J., & Chippaux, M. (1982) · Molecular and General Genetics MGG · doi:10.1007/bf00333001 · Cited by 62 · see citing works
Autogenous regulation of gene expression
Maloy, S., & Stewart, V. J. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.2.307-316.1993 · Cited by 60 · see citing works
Anaerobically expressed Escherichia coli genes identified by operon fusion techniques
Choe, M., & Reznikoff, W. S. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.19.6139-6146.1991 · Cited by 60 · see citing works
Identification of the formate dehydrogenases and genetic determinants of formate-dependent nitrite reduction by Escherichia coli K12
Darwin, A. J., Tormay, P., Page, L. V., Griffiths, L., & Cole, J. A. (1993) · Journal of General Microbiology · doi:10.1099/00221287-139-8-1829 · Cited by 58 · see citing works
The frdR gene of Escherichia coli globally regulates several operons involved in anaerobic growth in response to nitrate
Kalman, L. V., & Gunsalus, R. P. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.2.623-629.1988 · Cited by 56 · see citing works
Molybdenum-sensitive transcriptional regulation of the chlD locus of Escherichia coli
Miller, J. B., Scott, D., & Amy, N. K. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.5.1853-1860.1987 · Cited by 55 · see citing works
Molecular genetic analysis of an FNR‐dependent anaerobically inducible Escherichia coli promoter
Bell, A. I., Cole, J. A., & Busby, S. J. W. (1990) · Molecular Microbiology · doi:10.1111/j.1365-2958.1990.tb00553.x · Cited by 54 · see citing works
Mutational analysis reveals functional similarity between NARX, a nitrate sensor in Escherichia coli K-12, and the methyl-accepting chemotaxis proteins
Collins, L. A., Egan, S. M., & Stewart, V. J. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.11.3667-3675.1992 · Cited by 54 · see citing works
Influence of nar (nitrate reductase) genes on nitrate inhibition of formate-hydrogen lyase and fumarate reductase gene expression in Escherichia coli K-12
Stewart, V. J., & Berg, B. L. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.10.4437-4444.1988 · Cited by 53 · see citing works
Phosphorylation and dephosphorylation catalyzed in vitro by purified components of the nitrate sensing system, NarX and NarL.
Walker, M. S., & DeMoss, J. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52884-2 · Cited by 49 · see citing works
Identification of a second gene involved in global regulation of fumarate reductase and other nitrate-controlled genes for anaerobic respiration in Escherichia coli
Kalman, L. V., & Gunsalus, R. P. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.7.3810-3816.1989 · Cited by 47 · see citing works
Upstream sequence elements required for NarL-mediated activation of transcription from the narGHJI promoter of Escherichia coli.
Dong, X. R., Li, S., & DeMoss, J. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49687-7 · Cited by 47 · see citing works
Identification of the regulatory sequence of anaerobically expressed locus aeg-46.5
Choe, M., & Reznikoff, W. S. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.4.1165-1172.1993 · Cited by 46 · see citing works
In vivo requirement of integration host factor for nar (nitrate reductase) operon expression in Escherichia coli K-12
Rabin, R. S., Collins, L. A., & Stewart, V (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8701 · Cited by 44 · see citing works
The nirB promoter of Escherichia coli: location of nucleotide sequences essential for regulation by oxygen, the FNR protein and nitrite
Jayaraman, P.-S., Gaston, K., Cole, J. A., & Busby, S. J. W. (1988) · Molecular Microbiology · doi:10.1111/j.1365-2958.1988.tb00059.x · Cited by 44 · see citing works
Regulation of narK gene expression in Escherichia coli in response to anaerobiosis, nitrate, iron, and molybdenum
Kolesnikow, T., Schröder, I., & Gunsalus, R. P. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.22.7104-7111.1992 · Cited by 44 · see citing works
Single amino acid substitutions in the cAMP receptor protein specifically abolish regulation by the CytR repressor in Escherichia coli.
Søgaard‐Andersen, L., Mironov, A. S., Pedersen, H., Sukhodelets, V. V., & Valentin‐Hansen, P. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4921 · Cited by 43 · see citing works
Nitrate regulation of anaerobic respiratory gene expression in narX deletion mutants of Escherichia coli K-12
Egan, S. M., & Stewart, V. J. (1990) · Journal of Bacteriology · doi:10.1128/jb.172.9.5020-5029.1990 · Cited by 40 · see citing works
Role of alternative promoter elements in transcription from the nar promoter of Escherichia coli
Walker, M. S., & DeMoss, J. A. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.4.1119-1123.1992 · Cited by 40 · see citing works
Regulation of the adhE gene, which encodes ethanol dehydrogenase in Escherichia coli
Chen, Y. M., & Lin, E. C. C. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.24.8009-8013.1991 · Cited by 39 · see citing works
Mutational analysis of nitrate regulatory gene narL in Escherichia coli K-12
Egan, S. M., & Stewart, V. J. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.14.4424-4432.1991 · Cited by 39 · see citing works
Promoter sequence requirements for Fnr‐dependent activation of transcription of the narGHJI operon
Walker, M. S., & DeMoss, J. A. (1991) · Molecular Microbiology · doi:10.1111/j.1365-2958.1991.tb02116.x · Cited by 38 · see citing works
Molybdenum effector of fumarate reductase repression and nitrate reductase induction in Escherichia coli
Iuchi, S., & Lin, E. C. C. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.8.3720-3725.1987 · Cited by 37 · see citing works
Molybdenum accumulation in chlD mutants of Escherichia coli
Scott, D., & Amy, N. K. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.3.1284-1287.1989 · Cited by 37 · see citing works
Autoregulation of the nar operon encoding nitrate reductase in Escherichia coli
Bonnefoy, V., Pascal, M., Ratouchniak, J., & Chippaux, M. (1986) · Molecular and General Genetics MGG · doi:10.1007/bf00330207 · Cited by 28 · see citing works
Identification of functional cis‐acting sequences involved in regulation of narK gene expression in Escherichia coli
Bonrtefoy, V., & DeMoss, J. A. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb01795.x · Cited by 15 · see citing works
Alteration by mutation of the control by oxygen of the nar operon in Escherichia coli
Bonnefoy, V., Pascal, M., Ratouchniak, J., & Chippaux, M. (1986) · Molecular and General Genetics MGG · doi:10.1007/bf00430449 · Cited by 11 · see citing works

Flagged first, then by citations

Sorted by citations

Two-Component Signal Transduction
Stock, A., Robinson, V. L., & Goudreau, P. N. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.183 · Cited by 3,653 · see citing works
Nitrogen control in bacteria
Merrick, M. J., & Edwards, R. A. (1995) · Microbiological Reviews · doi:10.1128/mr.59.4.604-622.1995 · Cited by 752 · see citing works
Alternative respiratory pathways of Escherichia coli: energetics and transcriptional regulation in response to electron acceptors
Unden, G., & Bongaerts, J. (1997) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(97)00034-0 · Cited by 744 · see citing works
Enzymes and associated electron transport systems that catalyse the respiratory reduction of nitrogen oxides and oxyanions
Berks, B. C., Ferguson, S. J., Moir, J. W. B., & Richardson, D. J. (1995) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(95)00092-5 · Cited by 596 · see citing works
DNRA: A short-circuit in biological N-cycling to conserve nitrogen in terrestrial ecosystems
Pandey, C. B., Kumar, U., Kaviraj, M., Minick, K. J., Mishra, A. K., & Singh, J. S. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.139710 · Cited by 430 · see citing works
Nitrate and periplasmic nitrate reductases
Sparacino-Watkins, C., Stolz, J. F., & Basu, P. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60249d · Cited by 426 · see citing works
The Steady-State Internal Redox State (NADH/NAD) Reflects the External Redox State and Is Correlated with Catabolic Adaptation in Escherichia coli
Graef, M. R., Alexeeva, S., Snoep, J. L., & de Mattos, M. J. T. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.8.2351-2357.1999 · Cited by 329 · see citing works
ANAEROBIC GROWTH OF A “STRICT AEROBE” (BACILLUS SUBTILIS)
NAKANO, M. M., & Zuber, P. (1998) · Annual Review of Microbiology · doi:10.1146/annurev.micro.52.1.165 · Cited by 322 · see citing works
Molecular analysis of ammonia oxidation and denitrification in natural environments
Bothe, H., Jost, G., Schloter, M., Ward, B. B., & Witzel, K. (2000) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2000.tb00566.x · Cited by 314 · see citing works
Dissimilatory Metabolism of Nitrogen Oxides in Bacteria: Comparative Reconstruction of Transcriptional Networks
Rodionov, D. A., Dubchak, I. L., Arkin, A. P., Alm, E. J., & Gelfand, M. S. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0010055 · Cited by 296 · see citing works
A reassessment of the FNR regulon and transcriptomic analysis of the effects of nitrate, nitrite, NarXL, and NarQP as Escherichia coli K12 adapts from aerobic to anaerobic growth
Constantinidou, C., Hobman, J. L., Griffiths, L., Patel, M. D., Penn, C. W., Cole, J. A., & Overton, T. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512312200 · Cited by 280 · see citing works
The hydrogenases and formate dehydrogenases ofEscherichia coli
Sawers, R. G. (1994) · Antonie van Leeuwenhoek · doi:10.1007/bf00871633 · Cited by 246 · see citing works
Respiration of <i>Escherichia coli</i> in the Mouse Intestine
Jones, S. A., Chowdhury, F. Z., Fabich, A. J., Anderson, A., Schreiner, D. M., House, A. L., Autieri, S. M., Leatham, M. P., Lins, J. J., Jorgensen, M., et al. (2007) · Infection and Immunity · doi:10.1128/iai.00484-07 · Cited by 223 · see citing works
Linkage Map ofEscherichia coliK-12, Edition 10: The Traditional Map
Berlyn, M. K. B. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.3.814-984.1998 · Cited by 216 · see citing works
The Alternative Electron Acceptor Tetrathionate Supports B 12 -Dependent Anaerobic Growth of Salmonella enterica Serovar Typhimurium on Ethanolamine or 1,2-Propanediol
Price-Carter, M. L., Tingey, J., Bobik, T. A., & Roth, J. R. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.8.2463-2475.2001 · Cited by 207 · see citing works
Respiratory Detoxification of Nitric Oxide by the Cytochromec Nitrite Reductase of Escherichia coli
Poock, S. R., Leach, E. R., MOIR, J. W. B., Cole, J. A., & Richardson, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200731200 · Cited by 195 · see citing works
Nitrate reduction to ammonia by enteric bacteria: redundancy, or a strategy for survival during oxygen starvation?
Cole, J. (1996) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1996.tb08017.x · Cited by 195 · see citing works
Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health
Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works
Adaptation to Environmental Stimuli within the Host: Two-Component Signal Transduction Systems of Mycobacterium tuberculosis
Bretl, D. J., Demetriadou, C., & Zahrt, T. C. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05004-11 · Cited by 180 · see citing works
Isolation and characterization of hypophosphite‐resistant mutants of Escherichia coli: identification of the FocA protein, encoded by the pfl operon, as a putative formate transporter
Suppmann, B., & Sawers, R. G. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb00375.x · Cited by 180 · see citing works
Regulators of aerobic and anaerobic respiration in Bacillus subtilis
Sun, G., Sharkova, E. V., Chesnut, R. S., Birkey, S. M., Duggan, M. F., Sorokin, A., Pujić, P., Ehrlich, S. D., & Hulett, F. M. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.5.1374-1385.1996 · Cited by 176 · see citing works
Bacteria-mediated hypoxia functions as a signal for mosquito development
Coon, K. L., Valzania, L., McKinney, D. A., Vogel, K. J., Brown, M. R., & Strand, M. R. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702983114 · Cited by 165 · see citing works
Metabolic Engineering of Escherichia coli for Production of Mixed-Acid Fermentation End Products
Förster, A. H., & Gescher, J. (2014) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2014.00016 · Cited by 162 · see citing works
Generation of an endogenous DNA-methylating agent by nitrosation in Escherichia coli
Taverna, P., & Sedgwick, B. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.17.5105-5111.1996 · Cited by 158 · see citing works
The FNR Modulon and FNR-Regulated Gene Expression
Guest, J. R., Green, J. D., Irvine, A. S., & Spiro, S. (1996) · Springer eBooks · doi:10.1007/978-1-4684-8601-8_16 · Cited by 155 · see citing works
An essential single domain response regulator required for normal cell division and differentiation in Caulobacter crescentus.
Hecht, G. B., Lane, T. W., Ohta, N., Sommer, J. M., & Newton, A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00063.x · Cited by 149 · see citing works
Mycobacterial Dormancy Systems and Host Responses in Tuberculosis
Peddireddy, V., Doddam, S. N., & Ahmed, N. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00084 · Cited by 148 · see citing works
Nitrate sensing and signaling in plants
Bouguyon, E., Gojon, A., & Nacry, P. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.01.004 · Cited by 143 · see citing works
Adaptation of Escherichia coli to redox environments by gene expression
Iuchi, S., & Lin, E. C. C. (1993) · Molecular Microbiology · doi:10.1111/j.1365-2958.1993.tb01664.x · Cited by 142 · see citing works
The Periplasmic Nitrate Reductase NapABC Supports Luminal Growth of Salmonella enterica Serovar Typhimurium during Colitis
Lopez, C. A., Rivera-Chávez, F., Byndloss, M. X., & Bäumler, A. J. (2015) · Infection and Immunity · doi:10.1128/iai.00351-15 · Cited by 138 · see citing works
Structural Analysis of Ligand Stimulation of the Histidine Kinase NarX
Cheung, J., & Hendrickson, W. A. (2009) · Structure · doi:10.1016/j.str.2008.12.013 · Cited by 141 · see citing works
The napF and narG Nitrate Reductase Operons in Escherichia coli Are Differentially Expressed in Response to Submicromolar Concentrations of Nitrate but Not Nitrite
Wang, H., Tseng, C., & Gunsalus, R. P. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.17.5303-5308.1999 · Cited by 137 · see citing works
Nitric Oxide Homeostasis in Salmonella typhimurium
Gilberthorpe, N. J., & Poole, R. K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708019200 · Cited by 130 · see citing works
Nitrate reduction as a marker for hypoxic shiftdown of Mycobacterium tuberculosis
Wayne, L. G., & Hayes, L. G. (1998) · Tubercle and Lung Disease · doi:10.1054/tuld.1998.0015 · Cited by 127 · see citing works
Fumarate Regulation of Gene Expression in Escherichia coli by the DcuSR ( dcuSR Genes) Two-Component Regulatory System
Zientz, E., Bongaerts, J., & Unden, G. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.20.5421-5425.1998 · Cited by 126 · see citing works
Transcriptional regulation of the proton translocating NADH dehydrogenase (nuoA‐N) of Escherichia coli by electron acceptors, electron donors and gene regulators
Bongaerts, J., Zoske, S., Weidner, U., & Linden, G. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02416.x · Cited by 122 · see citing works
C 4 -Dicarboxylate Utilization in Aerobic and Anaerobic Growth
Unden, G., Strecker, A., Kleefeld, A., & Kim, O. B. (2016) · EcoSal Plus · doi:10.1128/ecosalplus.esp-0021-2015 · Cited by 116 · see citing works
Co‐ordinated regulation of amino sugar biosynthesis and degradation: the NagC repressor acts as both an activator and a repressor for the transcription of the glmUS operon and requires two separated NagC binding sites.
PLUMBRIDGE, J. A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00067.x · Cited by 114 · see citing works
FlhD/FlhC Is a Regulator of Anaerobic Respiration and the Entner-Doudoroff Pathway through Induction of the Methyl-Accepting Chemotaxis Protein Aer
Prüβ, B. M., Campbell, J. W., Dyk, T. K. V., Zhu, C., Kogan, Y. N., & Matsumura, P. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.2.534-543.2003 · Cited by 115 · see citing works
A complex network regulates expression of eps and other virulence genes of Pseudomonas solanacearum
Huang, J., Carney, B., Denny, T. P., Weissinger, A. K., & Schell, M. A. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.5.1259-1267.1995 · Cited by 110 · see citing works
Expression and characterization of the Escherichia coli fdo locus and a possible physiological role for aerobic formate dehydrogenase
Abaibou, H., Pommier, J., Benoit, S. L., Giordano, G., & Mandrand‐Berthelot, M. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.24.7141-7149.1995 · Cited by 109 · see citing works
RpoS-Regulated Genes of Escherichia coli Identified by Random lacZ Fusion Mutagenesis
Vijayakumar, S., Kirchhof, M. G., Patten, C. L., & Schellhorn, H. E. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.24.8499-8507.2004 · Cited by 109 · see citing works
Spontaneous tandem amplification and deletion of the Shiga toxin operon in Shigella dysenteriae 1
McDonough, M. A., & Butterton, J. R. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01669.x · Cited by 106 · see citing works
Physiology and interaction of nitrate and nitrite reduction in Staphylococcus carnosus
Neubauer, H., & Götz, F. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.7.2005-2009.1996 · Cited by 105 · see citing works
Quantitative proteomics reveals dynamic responses of Synechocystis sp. PCC 6803 to next-generation biofuel butanol
Tian, X., Chen, L., Wang, J., Qiao, J., & Zhang, W. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.10.002 · Cited by 103 · see citing works
Oxygen regulated gene expression in facultatively anaerobic bacteria
Unden, G., Becker, S., Bongaerts, J., Schirawski, J., & Six, S. (1994) · Antonie van Leeuwenhoek · doi:10.1007/bf00871629 · Cited by 102 · see citing works
Sequence analysis of bacterial redox enzyme maturation proteins (REMPs)
Turner, R. J., Papish, A. L., & Sargent, F. (2004) · Canadian Journal of Microbiology · doi:10.1139/w03-117 · Cited by 102 · see citing works
Untangling the molecular mechanisms and functions of nitrate to improve nitrogen use efficiency
Iqbal, A., Dong, Q., Alamzeb, M., Xiangru, W., Huiping, G., Zhang, H., Pang, N., Zhang, X., & Meizhen, S. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10085 · Cited by 98 · see citing works
Fumarate: Multiple functions of a simple metabolite
Araújo, W. L., Nunes‐Nesi, A., & Fernie, A. R. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.02.028 · Cited by 98 · see citing works
Coordinated Regulation of the Neisseria gonorrhoeae-truncated Denitrification Pathway by the Nitric Oxide-sensitive Repressor, NsrR, and Nitrite-insensitive NarQ-NarP
Overton, T. W., Whitehead, R. N., Li, Y., Snyder, L. A. S., Saunders, N. J. S. G., Smith, H. C., & Cole, J. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607056200 · Cited by 93 · see citing works
The hybrid‐cluster protein (‘prismane protein’) from Escherichia coli
van den Berg, W., Hagen, W. R., & van Dongen, W. M. A. M. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01032.x · Cited by 92 · see citing works
Control of FNR function of Escherichia coli by O2 and reducing conditions.
Unden, G., Achebach, S., Holighaus, G., Tran, H.-D., Wackwitz, B., & Zeuner, Y. (2002) · PubMed · Cited by 91 · see citing works
Redox Biology of Tuberculosis Pathogenesis
Trivedi, A., Singh, N., Bhat, S. A., Gupta, P., & Kumar, A. (2012) · Advances in Microbial Physiology · doi:10.1016/b978-0-12-398264-3.00004-8 · Cited by 88 · see citing works
FlhD/FlhC-regulated promoters analyzed by gene array and lacZ gene fusions
Ã, B. M. P. ⁄., Liu, X., Hendrickson, W. G., & Matsumura, P. (2001) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2001.tb10588.x · Cited by 87 · see citing works
Oxygen reactions with bacterial oxidases and globins: binding, reduction and regulation
Poole, R. K. (1994) · Antonie van Leeuwenhoek · doi:10.1007/bf00872215 · Cited by 87 · see citing works
Synergistic Activation of Transcription by Bacteriophage λ cI Protein and E. coli cAMP Receptor Protein
Joung, J. K., Koepp, D. M., & Hochschild, A. (1994) · Science · doi:10.1126/science.8091212 · Cited by 82 · see citing works
The NIT domain: a predicted nitrate-responsive module in bacterial sensory receptors
Shu, C. J., Ulrich, L. E., & Zhulin, I. B. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00032-x · Cited by 81 · see citing works
Nitrite and nitrate regulation at the promoters of two Escherichia coli operons encoding nitrite reductase: identification of common target heptamers for both NarP‐ and NarL‐dependent regulation
Tyson, K. L., Cole, J. A., & Busby, S. J. W. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb00495.x · Cited by 81 · see citing works
Signal-Dependent Phosphorylation of the Membrane-Bound NarX Two-Component Sensor-Transmitter Protein of Escherichia coli : Nitrate Elicits a Superior Anion Ligand Response Compared to Nitrite
Lee, A. I., Delgado, A., & Gunsalus, R. P. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.17.5309-5316.1999 · Cited by 80 · see citing works
The torR gene of Escherichia coli encodes a response regulator protein involved in the expression of the trimethylamine N-oxide reductase genes
Simon, G., Méjean, V., Jourlin‐Castelli, C., Chippaux, M., & Pascal, M. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.18.5601-5606.1994 · Cited by 79 · see citing works
Adaptation of Bacillus subtilis to oxygen limitation
NAKANO, M. M., & Hulett, F. M. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1997.tb12744.x · Cited by 77 · see citing works
Transport of C4‐dicarboxylates by anaerobically grown Escherichia coli
ENGEL, P., Krämer, R., & Unden, G. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb18903.x · Cited by 74 · see citing works
Nitrate reductases inEscherichia coli
Bonnefoy, V., & DeMoss, J. A. (1994) · Antonie van Leeuwenhoek · doi:10.1007/bf00871632 · Cited by 70 · see citing works
The pathogen Neisseria meningitidis requires oxygen, but supplements growth by denitrification. Nitrite, nitric oxide and oxygen control respiratory flux at genetic and metabolic levels
Rock, J. D., Mahnane, M. R., Anjum, M. F., Shaw, J. G., Read, R. C., & MOIR, J. W. B. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04866.x · Cited by 67 · see citing works
A NarX–Tar chimera mediates repellent chemotaxis to nitrate and nitrite
Ward, S. M., Delgado, A., Gunsalus, R. P., & Manson, M. D. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02902.x · Cited by 66 · see citing works
Identification and isolation of a gene required for nitrate assimilation and anaerobic growth of Bacillus subtilis
Glaser, P., Danchin, A., Kunst, F., Zuber, P., & NAKANO, M. M. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.4.1112-1115.1995 · Cited by 65 · see citing works
Regulation of nitrate and nitrite reductase synthesis in enterobacteria
Stewart, V. (1994) · Antonie van Leeuwenhoek · doi:10.1007/bf00871631 · Cited by 62 · see citing works
The mechanism of redox sensing in Mycobacterium tuberculosis
Bhat, S. A., Singh, N., Trivedi, A., Kansal, P., Gupta, P. K., & Kumar, A. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.008 · Cited by 63 · see citing works
Effects of nitrate respiration on expression of the Arc-controlled operons encoding succinate dehydrogenase and flavin-linked L-lactate dehydrogenase
Iuchi, S., Aristarkhov, A., Dong, J., Taylor, J. S., & Lin, E. C. C. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.6.1695-1701.1994 · Cited by 64 · see citing works
Regulation of transcription initiation at the Escherichia coli nir operon promoter: a new mechanism to account for co‐dependence on two transcription factors
Wu, H., Tyson, K. L., Cole, J. A., & Busby, S. J. W. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00699.x · Cited by 63 · see citing works
Salmonella typhi mutants defective in anaerobic respiration are impaired in their ability to replicate within epithelial cells
Contreras, I., Toro, C. S., Troncoso, G., & Mora, G. C. (1997) · Microbiology · doi:10.1099/00221287-143-8-2665 · Cited by 61 · see citing works
Regulated expression in vitro of genes coding for formate hydrogenlyase components of Escherichia coli.
Hopper, S., Babst, M., Schlensog, V., Fischer, H., Hennecke, H., & Böck, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32211-1 · Cited by 58 · see citing works
Expression of the Escherichia coli NRZ nitrate reductase is highly growth phase dependent and is controlled by RpoS, the alternative vegetative sigma factor
Chang, L., Wei, L. I. C., Audia, J. P., Morton, R. A., & Schellhorn, H. E. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01637.x · Cited by 57 · see citing works
CitA/CitB Two-Component System Regulating Citrate Fermentation in Escherichia coli and Its Relation to the DcuS/DcuR System In Vivo
Scheu, P. D., Witan, J., Rauschmeier, M., Graf, S., Liao, Y.-F., Ebert‐Jung, A., Basché, T., Erker, W., & Unden, G. (2011) · Journal of Bacteriology · doi:10.1128/jb.06345-11 · Cited by 56 · see citing works
Re-design of Rhodobacter sphaeroides Dimethyl Sulfoxide Reductase
Hilton, J. C., Temple, C. A., & Rajagopalan, K. V. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8428 · Cited by 56 · see citing works
Anaerobic regulation of the Escherichia coli dmsABC operon requires the molybdate‐responsive regulator ModE
McNicholas, P. M., Chiang, R. C., & Gunsalus, R. P. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00675.x · Cited by 56 · see citing works
Growth phase-dependent regulation of nuoA-N expression in Escherichia coli K-12 by the Fis protein: upstream binding sites and bioenergetic significance
Wackwitz, B., Bongaerts, J., Goodman, S. D., & Unden, G. (1999) · Molecular and General Genetics MGG · doi:10.1007/s004380051153 · Cited by 54 · see citing works
Functioning of DcuC as the C 4 -Dicarboxylate Carrier during Glucose Fermentation by Escherichia coli
Zientz, E., Janausch, I. G., Six, S., & Unden, G. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.12.3716-3720.1999 · Cited by 53 · see citing works
The NAR Modulon Systems: Nitrate and Nitrite Regulation of Anaerobic Gene Expression
Darwin, A. J., & Stewart, V. J. (1996) · Springer eBooks · doi:10.1007/978-1-4684-8601-8_17 · Cited by 53 · see citing works
Regulation of expression of terminal oxidases in Paracoccus denitrificans
Otten, M. F., Stork, D. M., Reijnders, W. N. M., Westerhoff, H. V., & van Spanning, R. J. M. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02131.x · Cited by 50 · see citing works
Dual Sensors and Dual Response Regulators Interact to Control Nitrate- and Nitrite-Responsive Gene Expression inEscherichia coli
Stewart, V. J., & Rabin, R. S. (2014) · ASM Press eBooks · doi:10.1128/9781555818319.ch14 · Cited by 50 · see citing works
Identification and characterization of the caiF gene encoding a potential transcriptional activator of carnitine metabolism in Escherichia coli
Eichler, K., Buchet, A., Lemke, R., Kleber, H. ‐., & Mandrand‐Berthelot, M. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.5.1248-1257.1996 · Cited by 49 · see citing works
Respiration of Nitrate and Nitrite
Cole, J. A., & Richardson, D. J. (2008) · EcoSal Plus · doi:10.1128/ecosal.3.2.5 · Cited by 48 · see citing works
Membrane Morphology and Leukotoxin Secretion Are Associated with a Novel Membrane Protein ofAggregatibacter actinomycetemcomitans
Gallant, C. V., Sedic, M., Chicoine, E. A., Ruíz, T., & Mintz, K. P. (2008) · Journal of Bacteriology · doi:10.1128/jb.00548-08 · Cited by 45 · see citing works
The Nitrogen Cycle: Denitrification and its Relationship to N2 Fixation
van Spanning, R. J. M., Delgado, M. J., & Richardson, D. J. (2005) · Springer eBooks · doi:10.1007/1-4020-3544-6_13 · Cited by 44 · see citing works
ArnR, a Novel Transcriptional Regulator, Represses Expression of the narKGHJI Operon in Corynebacterium glutamicum
Nishimura, T., Teramoto, H., Vertès, A. A., Inui, M., & Yukawa, H. (2008) · Journal of Bacteriology · doi:10.1128/jb.01801-07 · Cited by 44 · see citing works
Control of the respiratory metabolism of Thermus thermophilus by the nitrate respiration conjugative element NCE
Cava, F., Laptenko, O., Borukhov, S. I., Chahlafi, Z., Blas‐Galindo, E., Gómez‐Puertas, P., & Berenguer, J. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05687.x · Cited by 43 · see citing works
Identification and structure of the nasR gene encoding a nitrate- and nitrite-responsive positive regulator of nasFEDCBA (nitrate assimilation) operon expression in Klebsiella pneumoniae M5al
Goldman, B. S., Lin, J. T., & Stewart, V. J. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.16.5077-5085.1994 · Cited by 42 · see citing works
The Leeuwenhoek Lecture, 1995. Adaptation to life without oxygen
Guest, J. R. (1995) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1995.0152 · Cited by 42 · see citing works
FNR‐dependent activation of the class II dmsA and narG promoters of Escherichia coli requires FNR‐activating regions 1 and 3
Lamberg, K., & Kiley, P. J. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.02172.x · Cited by 42 · see citing works
Genetic Identification of Three ABC Transporters as Essential Elements for Nitrate Respiration in Haloferax volcanii
Wanner, C., & Soppa, J. (1999) · Genetics · doi:10.1093/genetics/152.4.1417 · Cited by 39 · see citing works
Expression of the narX, narL, narP, and narQ genes of Escherichia coli K-12: regulation of the regulators
Darwin, A. J., & Stewart, V. J. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.13.3865-3869.1995 · Cited by 37 · see citing works
The Dissimilatory Reduction of Nitrate to Ammonia by Anaerobic Bacteria
Mohan, S. B., & Cole, J. A. (2007) · Elsevier eBooks · doi:10.1016/b978-044452857-5.50008-4 · Cited by 38 · see citing works
NarL‐phosphate must bind to multiple upstream sites to activate transcription the narG promoter of Escherichia coli
Walker, M. S., & DeMoss, J. A. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb01302.x · Cited by 37 · see citing works
Twin-arginine translocase may have a role in the chaperone function of NarJ from Escherichia coli
Chan, C. S., Howell, J., Workentine, M. L., & Turner, R. J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.02.133 · Cited by 35 · see citing works
Multiple nosZ promoters and anaerobic expression of nos genes necessary for Pseudomonas stutzeri nitrous oxide reductase and assembly of its copper centers
Cuypers, H., Jürgen, B., & Zumft, W. G. (1995) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(95)00128-4 · Cited by 35 · see citing works
A computational framework for gene regulatory network inference that combines multiple methods and datasets
Gupta, R., Stincone, A., Antczak, P., Durant, S., Bicknell, R., Bikfalvi, A., & Francesco Falciani, B. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-52 · Cited by 32 · see citing works
Physiological Roles for Two Periplasmic Nitrate Reductases in Rhodobacter sphaeroides 2.4.3 (ATCC 17025)
Hartsock, A., & Shapleigh, J. P. (2011) · Journal of Bacteriology · doi:10.1128/jb.05324-11 · Cited by 33 · see citing works
Nitrate repression of the Escherichia coli pfl operon is mediated by the dual sensors NarQ and NarX and the dual regulators NarL and NarP
Kaiser, M., & Sawers, R. G. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.13.3647-3655.1995 · Cited by 32 · see citing works
In Silico Identification and Experimental Characterization of Regulatory Elements Controlling the Expression of the Salmonella csrB and csrC Genes
Martínez-Chavarría, L. C., Martínez‐Flores, I., Salgado, H., Fernández‐Mora, M., Medina-Rivera, A., Puente, J. L., Collado‐Vides, J., & Bustamante, V. H. (2013) · Journal of Bacteriology · doi:10.1128/jb.00806-13 · Cited by 31 · see citing works

Nitrate and Nitrite Regulation of the Fnr-dependentaeg-46.5Promoter ofEscherichia coliK-12 is Mediated by Competition Between Homologous Response Regulators (NarL and NarP) for a Common DNA-binding Site
Darwin, A. J., & Stewart, V. J. (1995) · Journal of Molecular Biology · doi:10.1006/jmbi.1995.0412 · Cited by 71 · see citing works
Analysis of nitrate regulatory protein NarL‐binding sites in the fdnG and narG operon control regions of Escherichia coli K‐12
Darwin, A. J., Li, J., & Stewart, V. J. (1996) · Molecular Microbiology · doi:10.1046/j.1365-2958.1996.5491074.x · Cited by 51 · see citing works
Nitrite and nitrate regulation at the promoters of two Escherichia coli operons encoding nitrite reductase: identification of common target heptamers for both NarP‐ and NarL‐dependent regulation
Tyson, K. L., Cole, J. A., & Busby, S. J. W. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb00495.x · Cited by 81 · see citing works
Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12
Rabin, R. S., & Stewart, V. J. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.11.3259-3268.1993 · Cited by 223 · see citing works
Expression of the narX, narL, narP, and narQ genes of Escherichia coli K-12: regulation of the regulators
Darwin, A. J., & Stewart, V. J. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.13.3865-3869.1995 · Cited by 37 · see citing works

Authors: Stewart, V.
Affiliations: Cornell University (US)
Corresponding author: Stewart, Valley
ORCID: Stewart, Valley
Venue: Molecular Microbiology
Publisher: Wiley
Published: 1993-08
Volume: 9
Issue: 3
Pages: 425-434
ISSN: 0950-382X (ISSN-L)
1365-2958
DOI: 10.1111/j.1365-2958.1993.tb01704.x
OpenAlex: W2099926472
Cited by: 176
References: 57
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 5
FWCI: 2.46
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4835 d)
Locations: Molecular Microbiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: nitrate regulation, anaerobic respiration, Escherichia coli, NarL, NARP, NARX network, FNR, two-component systems, nitrate reductase, integration host factor, transcriptional regulation, dual regulation
MeSH terms: Nitrate Transporters, Anaerobiosis, Bacterial Proteins, Carrier Proteins, DNA-Binding Proteins, Escherichia coli, Genes, Bacterial, Iron-Sulfur Proteins, Nitrate Reductases, Nitrates, Oxygen Consumption, Gene Expression Regulation, Bacterial, Anion Transport Proteins, Escherichia coli Proteins, Nitrate Reductase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nitrate regulation of anaerobic respiratory gene expression in Escherichia coli

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks