The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Catabolite repression in Bacillus subtilis: a global regulatory mechanism for the Gram‐positive bacteria?
Abstract
Summary: Three components involved in catabolite repression (CR) of gene expression in Bacillus have been identified. The cis‐acting catabolite responsive element (CRE), which is present in many genes encoding carbon catabolic enzymes in various species of the Gram‐positive bacteria, mediates CR of several genes in Bacillus subtilis, Bacillus megaterium, and Staphylococcus xylosus. CR of most genes regulated via CRE is also affected by the trans‐acting factors CcpA and HPr. Similarities between CcpA and Lac and Gal repressors suggest binding of CcpA to CRE. HPr, a component of the phosphoenol pyruvate:sugar phosphotransferase system, undergoes regulatory phosphorylation at a serine residue by a fcuctose‐1,6‐diphosphate‐activated kinase. A mutant of HPr, which is not phosphorylatable at this position because of an exchange of serine to alanine, lacks CR of several catabolic activities. This mutant phenotype is similar to the one exhibited by a ccpA mutant. Direct protein‐protein interaction between CcpA and HPr(Ser‐P) was recently demonstrated and constitutes a link between metabolic activity and CR.
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Cites
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Wolfe, A. J. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.1.12-50.2005 · Cited by 1,233
From soil to gut:Bacillus cereus and its food poisoning toxins
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Kreth, J., Zhang, Y., & Herzberg, M. C. (2008) · Journal of Bacteriology · doi:10.1128/jb.00276-08 · Cited by 450
Acetoin Metabolism in Bacteria
Xiao, Z., & Xu, P. (2007) · Critical Reviews in Microbiology · doi:10.1080/10408410701364604 · Cited by 375
Regulation of Carbon Catabolism in Bacillus Species
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Self-citation
Metadata
- Authors
- Hueck, C. J., & Hillen, W.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1995-02
- Volume
- 15
- Issue
- 3
- Pages
- 395-401
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2001992240
- Cited by
- 281
- References
- 24
- FWCI
- 17.85
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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