The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
A family of bacterial regulators homologous to Gal and Lac repressors.
Open accessAbstract
We describe a family of proteins which regulate transcription of inducible genes in bacteria (GalR-LacI family). An alignment of the proteins in the GalR-LacI family is presented in which these proteins show a very high degree of similarity (60%) throughout the entire sequences. The homology is greatest among the amino-terminal DNA binding domains. Since a portion of the operator sequences occupied by these proteins is also conserved, a similar DNA structure may be required for specific recognition of DNA by members of the GalR-LacI family. Highly conserved motifs involved in effector binding and oligomerization are also identified. This compilation suggests a widespread conservation of these regulators among bacteria, and have strong implications for further study of peptide motifs in domain function, as well as pathways of protein evolution.
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Cites
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A comprehensive set of sequence analysis programs for the VAX
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The helix-turn-helix DNA binding motif
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DNA RECOGNITION BY PROTEINS WITH THE HELIX-TURN-HELIX MOTIF
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A large family of bacterial activator proteins.
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Control site location and transcriptional regulation in Escherichia coli
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Cited by
Regulation of Carbon Catabolism in Bacillus Species
Stülke, J., & Hillen, W. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.849 · Cited by 370
Engineering an allosteric transcription factor to respond to new ligands
Taylor, N. D., Garruss, A. S., Moretti, R., Chan, S., Arbing, M. A., Cascio, D., Rogers, J. K., Isaacs, F. J., Kosuri, S., Baker, D., et al. (2016) · Nature Methods · doi:10.1038/nmeth.3696 · Cited by 328
The repertoire of DNA-binding transcriptional regulators in Escherichia coli K-12
Perez-Rueda, E. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.8.1838 · Cited by 309
Saier, M. H. (1994) · Microbiological Reviews · doi:10.1128/mmbr.58.1.71-93.1994 · Cited by 275
Metadata
- Authors
- Weickert, M. J., & Adhya, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-08
- Volume
- 267
- Issue
- 22
- Pages
- 15869-15874
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1499816395
- Cited by
- 364
- References
- 35
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Weickert, M. J., & Adhya, S. (1992). A family of bacterial regulators homologous to Gal and Lac repressors. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)49615-4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
