The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Understanding the control of Pseudomonas aeruginosa alginate synthesis and the prospects for management of chronic infections in cystic fibrosis
Abstract
Summary: Decades of research have been dedicated to the study of the opportunistic pathogen Pseudomonas aeruginosa, a Gram‐negative, environmental bacterium that secretes the exopolysaccharide alginate during chronic lung infection of cystic fibrosis (CF) patients. Although P. aeruginosa utilizes a variety of factors to establish a successful infection in the lungs of CF patients, alginate has stood out as one of the best‐studied prognostic indicators of chronic lung infection. While the genetics, biosynthesis and regulation of alginate are well understood, questions still remain concerning its role in biofilm development and its potential as a therapeutic target. The purpose of this review is to provide a brief summary of alginate biosynthesis and regulation, and to highlight recent discoveries in the areas of alginate production, biofilm formation and vaccine design. This information is placed in context with a proposed P. aeruginosa infectious pathway, highlighting avenues for the use of existing therapies as well as the potential for novel agents to reduce or eliminate chronic infections in CF patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mechanisms of biofilm resistance to antimicrobial agents
Mah, T.-F. C., & O'Toole, G. A. (2001) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01913-2 · Cited by 3,921
Biofilm formation as microbial development
O'Toole, G., Kaplan, H. B., & Kolter, R. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.49 · Cited by 3,571
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development
O'Toole, G. A., & Kolter, R. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.01062.x · Cited by 2,697
Extracellular DNA Required for Bacterial Biofilm Formation
Whitchurch, C. B., Tolker-Nielsen, T., Ragas, P. C., & Mattick, J. S. (2002) · Science · doi:10.1126/science.295.5559.1487 · Cited by 2,203
Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia
Govan, J. R. W., & Deretic, V. P. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.3.539-574.1996 · Cited by 1,812
Pseudomonas aeruginosa Displays Multiple Phenotypes during Development as a Biofilm
Sauer, K., Camper, A. K., Ehrlich, G. D., Costerton, J. W., & Davies, D. G. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.4.1140-1154.2002 · Cited by 1,691 · cited 6×
“After attachment, P. aeruginosa develops microcolonies on both biotic and abiotic surfaces (O’Toole et al., 2000; Sauer et al., 2002; Jackson et al., 2003) (Fig.”
BackgroundMethodInfluentialLung Infections Associated with Cystic Fibrosis
Lyczak, J. B., Cannon, C. L., & Pier, G. B. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.2.194-222.2002 · Cited by 1,628
Bacterial Biofilms: An Emerging Link to Disease Pathogenesis
Parsek, M. R., & Singh, P. K. (2003) · Annual Review of Microbiology · doi:10.1146/annurev.micro.57.030502.090720 · Cited by 1,562
Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
Singh, P. K., Schaefer, A. L., Parsek, M. R., Moninger, T. O., Welsh, M. J., & Greenberg, E. P. (2000) · Nature · doi:10.1038/35037627 · Cited by 1,519
Research works printed but not linked: 28
- 10.1099/00221287-143-2-641 · doi:10.1099/00221287-143-2-641
- 10.1111/j.1365-2958.1996.tb02659.x · doi:10.1111/j.1365-2958.1996.tb02659.x
- Cryz S., 1997, Immunization of cystic fibrosis patients with a Pseudomonas aeruginosa O‐polysaccharide‐toxin A conjugate vaccine, Behring Inst Mitt, 98, 345
- Cystic Fibrosis Foundation., 2001, Cystic Fibrosis Foundation Patient Registry Annual Report.
- 10.1111/j.1365-2958.1991.tb02096.x · doi:10.1111/j.1365-2958.1991.tb02096.x
- Doring G., 1997, A multicenter vaccine trial using the Pseudomonas aeruginosa flagella vaccine IMMUNO in patients with cystic fibrosis, Behring Inst Mitt, 98, 338
- 10.1136/adc.85.1.62 · doi:10.1136/adc.85.1.62
- 10.1128/mr.60.3.539-574.1996 · doi:10.1128/mr.60.3.539-574.1996 · Paper page
- 10.1111/j.1574-6968.1990.tb04127.x · doi:10.1111/j.1574-6968.1990.tb04127.x
- 10.1128/IAI.69.11.6962-6969.2001 · doi:10.1128/iai.69.11.6962-6969.2001
- 10.1055/s-2004-815662 · doi:10.1055/s-2004-815662
- 10.1016/0378-1119(89)90136-4 · doi:10.1016/0378-1119(89)90136-4
- 10.1074/jbc.272.29.17952 · doi:10.1074/jbc.272.29.17952
- 10.1016/0378-1119(93)90477-K · doi:10.1016/0378-1119(93)90477-k
- 10.1046/j.1365-2958.2003.03525.x · DOI · Paper page
- 10.1016/S0378-1119(97)00380-6 · doi:10.1016/s0378-1119(97)00380-6
- 10.1128/jb.174.20.6624-6633.1992 · doi:10.1128/jb.174.20.6624-6633.1992
- Pier G.B., 1998, Pseudomonas aeruginosa: a key problem in cystic fibrosis, ASM News, 6, 339
- 10.1128/IAI.69.5.3510-3515.2001 · doi:10.1128/iai.69.5.3510-3515.2001
- 10.1046/j.1365-2958.2000.01830.x · doi:10.1046/j.1365-2958.2000.01830.x
- 10.1128/jb.177.9.2469-2474.1995 · doi:10.1128/jb.177.9.2469-2474.1995
- 10.1021/bi027328k · doi:10.1021/bi027328k
- 10.1099/13500872-140-7-1745 · doi:10.1099/13500872-140-7-1745
- 10.1128/IAI.71.7.3875-3884.2003 · doi:10.1128/iai.71.7.3875-3884.2003
- 10.1073/pnas.93.18.9839 · doi:10.1073/pnas.93.18.9839
- 10.1128/jb.176.16.5068-5076.1994 · doi:10.1128/jb.176.16.5068-5076.1994
- 10.1128/jb.173.4.1406-1413.1991 · doi:10.1128/jb.173.4.1406-1413.1991
- 10.1128/jb.179.1.187-193.1997 · doi:10.1128/jb.179.1.187-193.1997
Cited by
Alginate derivatization: A review of chemistry, properties and applications
Pawar, S. N., & Edgar, K. J. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.007 · Cited by 1,627
Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms
Karatan, E., & Watnick, P. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00041-08 · Cited by 1,048
Assembly and Development of the Pseudomonas aeruginosa Biofilm Matrix
Ma, L., Conover, M., Lu, H., Parsek, M. R., Bayles, K., & Wozniak, D. J. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000354 · Cited by 699
Self-citationMichel, G., Tonon, T., Scornet, D., Cock, J. M., & Kloareg, B. (2010) · New Phytologist · doi:10.1111/j.1469-8137.2010.03374.x · Cited by 419
Byrd, M. S., Sadovskaya, I., Vinogradov, E., Lu, H., Sprinkle, A. B., Richardson, S. H., Ma, L., Ralston, B., Parsek, M. R., Anderson, E. M., et al. (2009) · Molecular Microbiology · doi:10.1111/j.1365-2958.2009.06795.x · Cited by 386
Self-citation
Metadata
- Authors
- Ramsey, D. M., & Wozniak, D. J.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2005-03-07
- Volume
- 56
- Issue
- 2
- Pages
- 309-322
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2123818413
- Cited by
- 391
- References
- 106
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Understanding the control of Pseudomonas aeruginosa alginate synthesis and the prospects for management of chronic infections in cystic fibrosis. https://app.cochat.ai/papers/10.1111/j.1365-2958.2005.04552.x
- The paper
- Ramsey, D. M., & Wozniak, D. J. (2005). Understanding the control of Pseudomonas aeruginosa alginate synthesis and the prospects for management of chronic infections in cystic fibrosis. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2005.04552.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
