The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
An antisense RNA controls synthesis of an SOS‐induced toxin evolved from an antitoxin
Open accessAbstract
Summary: Only few small, regulatory RNAs encoded opposite another gene have been identified in bacteria. Here, we report the characterization of a locus where a small RNA (SymR) is encoded in cis to an SOS‐induced gene whose product shows homology to the antitoxin MazE (SymE). Synthesis of the SymE protein is tightly repressed at multiple levels by the LexA repressor, the SymR RNA and the Lon protease. SymE co‐purifies with ribosomes and overproduction of the protein leads to cell growth inhibition, decreased protein synthesis and increased RNA degradation. These properties are shared with several RNA endonuclease toxins of the toxin‐antitoxin modules, and we show that the SymE protein represents evolution of a toxin from the AbrB fold, whose representatives are typically antitoxins. We suggest that SymE promotion of RNA cleavage may be important for the recycling of RNAs damaged under SOS‐inducing conditions.
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Lewis, K. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134306 · Cited by 1,858
Antibiotic resistance and persistence—implications for human health and treatment perspectives
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Self-citationRegulation of growth and death in Escherichia coli by toxin–antitoxin systems
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Metadata
- Authors
- Kawano, M., Aravind, L., & Storz, G.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2007-04-24
- Volume
- 64
- Issue
- 3
- Pages
- 738-754
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2154662371
- Cited by
- 265
- References
- 52
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kawano, M., Aravind, L., & Storz, G. (2007). An antisense RNA controls synthesis of an SOS‐induced toxin evolved from an antitoxin. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2007.05688.x
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