The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The resuscitation‐promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro
Open accessAbstract
Summary: Mycobacterium tuberculosis contains five resuscitation‐promoting factor (Rpf)‐like proteins, RpfA‐E, that are implicated in resuscitation of this organism from dormancy via a mechanism involving hydrolysis of the peptidoglycan by Rpfs and partnering proteins. In this study, the rpfA‐E genes were shown to be collectively dispensable for growth of M. tuberculosis in broth culture. The defect in resuscitation of multiple mutants from a ‘non‐culturable’ state induced by starvation under anoxia was reversed by genetic complementation or addition of culture filtrate from wild‐type organisms confirming that the phenotype was associated with rpf ‐like gene loss and that the ‘non‐culturable’ cells of the mutant strains were viable. Other phenotypes uncovered by sequential deletion mutagenesis revealed a functional differentiation within this protein family. The quintuple mutant and its parent that retained only rpfD displayed delayed colony formation and hypersensitivity to detergent, effects not observed for mutants retaining only rpfE or rpfB . Furthermore, mutants retaining rpfD or rpfE were highly attenuated for growth in mice with the latter persisting better than the former in late‐stage infection. In conjunction, these results are indicative of a hierarchy in terms of function and/or potency with the Rpf family, with RpfB and RpfE ranking above RpfD.
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Self-citationTuberculosis: a problem with persistence
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Cited by
Current Perspectives on Viable but Non-Culturable (VBNC) Pathogenic Bacteria
Ramamurthy, T., Ghosh, A., Pazhani, G. P., & Shinoda, S. (2014) · Frontiers in Public Health · doi:10.3389/fpubh.2014.00103 · Cited by 462
Shiloh, M. U., & DiGiuseppe Champion, P. A. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.11.006 · Cited by 137
Pereira, A. C., Ramos, B., Reis, A. C., & Cunha, M. V. (2020) · Microorganisms · doi:10.3390/microorganisms8091380 · Cited by 101
Rifat, D., Chen, L., Kreiswirth, B. N., & Nuermberger, E. L. (2021) · mBio · doi:10.1128/mbio.01049-21 · Cited by 76
The Pathogenesis of Tuberculosis-The Koch Phenomenon Reinstated.
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Metadata
- Authors
- Kana, B. D., Gordhan, B. G., Downing, K. J., Sung, N., Vostroktunova, G., Machowski, E. E., Tsenova, L., Young, M., Kaprelyants, A., Kaplan, G., & Mizrahi, V.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2007-12-21
- Volume
- 67
- Issue
- 3
- Pages
- 672-684
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2020224454
- Cited by
- 295
- References
- 39
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kana, B. D., Gordhan, B. G., Downing, K. J., Sung, N., Vostroktunova, G., Machowski, E. E., Tsenova, L., Young, M., Kaprelyants, A., Kaplan, G., & Mizrahi, V. (2008). The resuscitation‐promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2007.06078.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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