To catch a killer. What can mycobacterial models teach us about Mycobacterium tuberculosis pathogenesis?

Shiloh, Michael U; DiGiuseppe Champion, Patricia A

doi:10.1016/j.mib.2009.11.006

Cited by 137Tuberculosis Research and EpidemiologyMycobacterium research and diagnosisInfectious Diseases and Tuberculosis

To catch a killer. What can mycobacterial models teach us about Mycobacterium tuberculosis pathogenesis?

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Shiloh, Michael U, DiGiuseppe Champion, Patricia A·2010·Current Opinion in Microbiology

DOI 10.1016/j.mib.2009.11.006PMC PMC2876343

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Abstract

Mycobacterium tuberculosis is the causative agent of the global tuberculosis epidemic. To combat this successful human pathogen we need a better understanding of the basic biology of mycobacterial pathogenesis. The use of mycobacterial model systems has the potential to greatly facilitate our understanding of how M. tuberculosis causes disease. Recently, studies using mycobacterial models, including M. bovis BCG, M. marinum, and M. smegmatis have significantly contributed to understanding M. tuberculosis. Specifically, there have been advances in genetic manipulation of M. tuberculosis using inducible promoters and recombineering that alleviate technical limitations in working with mycobacteria. Model systems have helped elucidate how secretion systems function at both the molecular level and during virulence. Mycobacterial models have also led to interesting hypotheses about how M. tuberculosis mediates latent infection and host response. While there is utility in using model systems to understand tuberculosis, each of these models represent distinct mycobacterial species with unique environmental adaptations. Directly comparing findings in model mycobacteria to those in M. tuberculosis will illuminate the similarities and differences between these species and increase our understanding of why M. tuberculosis is such a potent human pathogen.

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M. bovis BCG and M. marinum are slow-growing mycobacteria that are more closely related to M. tuberculosis and are used in a BSL-2 laboratory.
“Two alternative, slow-growing mycobacteria that are more closely related to M. tuberculosis and used in a BSL-2 laboratory are M. bovis BCG, the attenuated vaccine strain, and M. marinum, a fish pathogen, each with advantages for host infection studies over M. smegmatis (182, 183).”
From Mycobacterium smegmatis: The Vanguard of Mycobacterial Research (2023) · cites this paper as [183]
In “Why are mycobacterial models useful?” (page unavailable), the paper describes BCG as a slow-growing, attenuated member of the TB complex and a Category 2 organism. It describes M. marinum as growing more slowly than M. smegmatis and sharing virulence determinants with M. tuberculosis, but does not state that M. marinum can be used in a BSL-2 laboratory. (LLM, conf=0.85)
Experimental — accuracy not yet measured
M. bovis BCG and M. marinum each have advantages for host infection studies over M. smegmatis.
“each with advantages for host infection studies over M. smegmatis (182, 183)”
From Mycobacterium smegmatis: The Vanguard of Mycobacterial Research (2023) · cites this paper as [183]

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Authors: Shiloh, M. U., & DiGiuseppe Champion, P. A.
Affiliations: University of California, San Francisco (US)
ORCID: Shiloh, Michael U
Venue: Current Opinion in Microbiology
Publisher: Elsevier BV
Published: 2010-02
Volume: 13
Issue: 1
Pages: 86-92
ISSN: 1369-5274 (ISSN-L)
DOI: 10.1016/j.mib.2009.11.006
PMC: PMC2876343
OpenAlex: W2070413611
Cited by: 137
References: 50
Citations by year: 2026: 4 · 2025: 12 · 2024: 9 · 2023: 11 · 2022: 5 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 8 · 2014: 6 · 2013: 7 · 2012: 8
FWCI: 0.86
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Microbiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (K08AI076632)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
Keywords: Mycobacterium tuberculosis, tuberculosis pathogenesis, Mycobacterium bovis BCG, Mycobacterium marinum, Mycobacterium smegmatis, secretion systems, virulence, latent infection, host response, recombineering, inducible promoters
MeSH terms: Humans, Models, Biological, Mycobacterium bovis, Mycobacterium tuberculosis, Tuberculosis, Virulence, Mycobacterium smegmatis, Host-Pathogen Interactions

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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

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To catch a killer. What can mycobacterial models teach us about Mycobacterium tuberculosis pathogenesis?

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