The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Programmed drug‐dependent ribosome stalling
Open accessAbstract
Summary: The ribosome has the intrinsic capacity to monitor the sequence and structure of the nascent peptide. This fundamental property of the ribosome is often exploited in regulation of gene expression, in particular, for activation of expression of genes conferring resistance to ribosome‐targeting antibiotics. Induction of expression of these genes is controlled by the programmed stalling of the ribosome at a regulatory open reading frame located upstream of the resistance cistron. Formation of the stalled translation complex depends on the presence of an antibiotic in the ribosome exit tunnel and the sequence of the nascent peptide. In this review, we summarize our current understanding of the molecular mechanisms of drug‐ and nascent peptide‐dependent ribosome stalling.
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Citations
Cites
Upstream Open Reading Frames as Regulators of mRNA Translation
Morris, D. R., & Geballe, A. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8635-8642.2000 · Cited by 736
Molecular Mechanism of Drug-Dependent Ribosome Stalling
Vazquez-Laslop, N., Thum, C., & Mankin, A. S. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.026 · Cited by 260
Self-citation
Cited by
Ribosome-targeting antibiotics and mechanisms of bacterial resistance
Wilson, D. N. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3155 · Cited by 1,054
Mechanisms of Integral Membrane Protein Insertion and Folding
Cymer, F., von Heijne, G., & White, S. H. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.09.014 · Cited by 360
Small Proteins Can No Longer Be Ignored
Storz, G., Wolf, Y. I., & Ramamurthi, K. S. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-070611-102400 · Cited by 359
The A-Z of bacterial translation inhibitors
Wilson, D. N. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409230903307311 · Cited by 322
Alternative ORFs and small ORFs: shedding light on the dark proteome
Orr, M. W., Mao, Y., Storz, G., & Qian, S.-B. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkz734 · Cited by 319
Metadata
- Authors
- Ramu, H., Mankin, A., & Vazquez‐Laslop, N.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2009-02
- Volume
- 71
- Issue
- 4
- Pages
- 811-824
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2056067932
- Cited by
- 164
- References
- 2
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ramu, H., Mankin, A., & Vazquez‐Laslop, N. (2009). Programmed drug‐dependent ribosome stalling. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2008.06576.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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