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Cited by 58Gastrointestinal motility and disordersCongenital gastrointestinal and neural anomaliesGut microbiota and health

The ileocolonic sphincter

Malbert, C‐h.·2005·Neurogastroenterology & Motility
DOI 10.1111/j.1365-2982.2005.00657.x
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Abstract

Abstract The human ileocolonic sphincter (ICS) develops a sustained tone mainly due to propagated and not propagated phasic motor activity. The ileocaecocolonic segment is also able to behave, yet uncommonly, as a synchronized segment involving propagated contractions originating from the ileum and migrating to the proximal colon. The ICS motor activity alone has a limited role towards forward flow. On the contrary, the functional entity corresponding to the distal ileum and the ICS provides a clearance mechanism for reflux of colonic contents into the small intestine. The presence of short chain fatty acids (SCFA) in the distal ileum, sensed either by endocrine cells or chemo‐sensitive vagal afferents, is an important actor in triggering this clearance mechanism. The ICS tone is in part myogenic but a neuronal nitrergic component is also involved. Reflex excitatory and inhibitory responses of the ICS originating from ileal or colonic distension involve primarily spinal nitrergic and adrenergic pathways.

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Crossref · 10.1111/j.1365-2982.2005.00657.x

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  • Metabolic products of intestinal bacteria, such as short-chain fatty acids or chemotactic peptides, are able to stimulate the enteric nervous system and influence the rate of gut transit.

    “Metabolic products of intestinal bacteria, such as short-chain fatty acids or chemotactic peptides (for example, N-formylmethionyl–leucine–phenylalanine) are able to stimulate the enteric nervous system and influence the rate of gut transit.38-40”

    From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [40]

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Authors
Malbert, C.
Affiliations
Institut National de la Recherche Agronomique (FR)
Corresponding author
Malbert, C‐h.
Venue
Neurogastroenterology & Motility
Publisher
Wiley
Published
2005-04-18
Volume
17
Issue
s1
Pages
41-49
ISSN
  • 1350-1925 (ISSN-L)
  • 1365-2982
DOI
10.1111/j.1365-2982.2005.00657.x
OpenAlex
W2032351854
Cited by
58
References
83
Citations by year
2025: 1 · 2024: 2 · 2023: 3 · 2022: 6 · 2020: 2 · 2019: 3 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 3
FWCI
0.41
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Neurogastroenterology & Motility (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
sphincter tone, migrating motor complex, short-chain fatty acids, nitrergic neurotransmission, intestinal motility
MeSH terms
Animals, Colon, Gastrointestinal Motility, Humans, Ileocecal Valve, Ileum

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