Cited by 164Diabetes Treatment and ManagementRegulation of Appetite and ObesityPancreatic function and diabetes

The DOI matches its Crossref record; 48 of the 51 references it cites were found in a registry or an index.

Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis: Incretins, gastric emptying and metabolic control

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Abstract

BACKGROUND: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are major incretins with important effects on glucoregulatory functions. The aim of this study was to investigate effects of GIP and GLP-1 on gastric emptying and appetite after a mixed meal, and effects on insulin secretion and glucose disposal in humans. METHODS: Randomized crossover single-blind study in 17 healthy volunteers receiving GIP (2 or 5 pmol kg(-1) min(-1), n = 8), GLP-1 (0.75 pmol kg(-1) min(-1), n = 9) or NaCl for 180 min with a radionuclide-labeled omelette and fruit punch (370 kcal). Outcome measures were gastric emptying rate, insulinogenic index, hunger, satiety, desire to eat, and prospective food consumption. Blood was analyzed for GIP, GLP-1, glucagon, C-peptide, peptide YY (PYY) and ghrelin. KEY RESULTS: Glucose-dependent insulinotropic polypeptide 2 and 5 pmol kg(-1) min(-1) decreased gastric half-emptying time from 128.5 ± 34.0 min in controls to 93.3 ± 6.3 and 85.2 ± 11.0 min (P < 0.05). Glucose-dependent insulinotropic polypeptide 5 pmol kg(-1) min(-1) decreased postprandial glucose (P < 0.001) and insulin (P < 0.05) with increased insulinogenic index. Glucose-dependent insulinotropic polypeptide had no effects on hunger, desire to eat, satiety or prospective consumption. Glucagon-like peptide-1 0.75 pmol kg(-1) min(-1) increased half-emptying time from 76.6 ± 7.6 min to 329.4 ± 71.6 (P < 0.01). Glucagon-like peptide-1 decreased plasma glucose and insulin (both P < 0.05-0.001), and increased insulinogenic index markedly. Hunger, desire to eat and prospective consumption were decreased (P < 0.05), and satiety borderline increased (P < 0.06). CONCLUSION & INFERENCES: The incretin effect of GIP and GLP-1 differs as GLP-1 exerts a strong glucoregulatory incretin through inhibition of gastric emptying, which GIP does not. Thus, GLP-1 as incretin mimetic may offer unique benefits in terms of weight loss in treatment of type 2 diabetes.

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Crossref · 10.1111/j.1365-2982.2010.01554.x

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Metadata

Authors
Edholm, T., Degerblad, M., Grybäck, P., Hilsted, L., Holst, J. J., Jacobsson, H., Efendic, S., Schmidt, P. T., & Hellström, P. M.
Affiliations
  • Karolinska Institutet (SE)
  • Rigshospitalet (DK)
  • University of Copenhagen (DK)
  • Uppsala University (SE)
Corresponding author
Hellström, P. M.
Venue
Neurogastroenterology & Motility
Publisher
Wiley
Published
2010-06-24
Volume
22
Issue
11
Pages
1191-e315
ISSN
1350-1925 (ISSN-L)
OpenAlex
W1589619385
Cited by
164
References
51
Citations by year
2026: 10 · 2025: 18 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 15 · 2020: 5 · 2019: 16 · 2018: 13 · 2017: 13 · 2016: 9 · 2015: 7 · 2014: 9 · 2013: 12 · 2012: 10
FWCI
7.02
Type
journal article
Language
en
Open access
Locations
  • Neurogastroenterology & Motility (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
  • Stockholms Läns Landsting
  • Vetenskapsrådet
  • Uppsala Universitet
  • Landstinget i Uppsala län
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords
glucagon-like peptide-1, incretins, gastric emptying, appetite, insulin secretion, glucose homeostasis, postprandial blood glucose, insulinogenic index, satiety, hunger, mixed meal, peptide YY, ghrelin, glucagon, C-peptide, food intake regulation
MeSH terms
Adult, Appetite, Blood Glucose, C-Peptide, Double-Blind Method, Female, Gastric Emptying, Gastric Inhibitory Polypeptide, Glucagon, Homeostasis, Humans, Hunger, Immunoassay, Insulin, Male, Satiety Response, Cross-Over Studies, Peptide YY, Glucagon-Like Peptide 1, Ghrelin, Incretins

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