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Cited by 263Gastrointestinal motility and disordersGut microbiota and healthMicroscopic Colitis

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Increase in fecal primary bile acids and dysbiosis in patients with diarrhea‐predominant irritable bowel syndrome

Duboc, H., Rainteau, D., Rajca, S., Humbert, L., Farabos, D., Maubert, M., Grondin, V., Jouet, P., Bouhassira, D., Seksik, P., Sokol, H., Coffin, B., Sabaté, J. M.·2012·Neurogastroenterology & Motility
DOI 10.1111/j.1365-2982.2012.01893.x
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Abstract

Background Irritable bowel syndrome (IBS) is a multifactorial disease for which a dysbiosis of the gut microbiota has been described. Bile acids (BA) could play a role as they are endogenous laxatives and are metabolized by gut microbiota. We compared fecal BA profiles and microbiota in healthy subjects (HS) and patients with diarrhea‐predominant IBS (IBS‐D), and we searched for an association with symptoms. Methods Clinical features and stool samples were collected in IBS‐D patients and HS. Fecal BA profiles were generated using HPLC coupled to tandem mass spectrometry. The fecal microbiota composition was assessed by q‐PCR targeting dominant bacterial groups and species implicated in BA transformation. Key Results Fourteen IBS‐D patients and 18 HS were included. The two groups were comparable in terms of age and sex. The percentage of fecal primary BA was significantly higher in IBS‐D patients than in HS, and it was significantly correlated with stool consistency and frequency. Fecal counts of all bacteria, lactobacillus, coccoides, leptum and Faecalibacterium prausnitzii were similar. There was a significant increase of Escherichia coli and a significant decrease of leptum and bifidobacterium in IBS‐D patients. Conclusions & Inferences We report an increase of primary BA in the feces of IBS‐D patients compared to HS, correlated with stool consistency and frequency. A dysbiosis of different bacterial groups was detected, some of them involved in BA transformation. As the gut microbiota is the exclusive pathway to transform primary into secondary BA, this suggests a functional consequence of dysbiosis, leading to lower BA transformation.

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Crossref · 10.1111/j.1365-2982.2012.01893.x

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Metadata

Authors
Duboc, H., Rainteau, D., Rajca, S., Humbert, L., Farabos, D., Maubert, M., Grondin, V., Jouet, P., Bouhassira, D., Seksik, P., Sokol, H., Coffin, B., & Sabaté, J. M.
Affiliations
Inserm (FR)
Corresponding author
Duboc, H.
ORCID
Venue
Neurogastroenterology & Motility
Publisher
Wiley
Published
2012-02-22
Volume
24
Issue
6
Pages
513
ISSN
  • 1350-1925 (ISSN-L)
  • 1365-2982
DOI
10.1111/j.1365-2982.2012.01893.x
OpenAlex
W1482883615
Cited by
256
References
42
Citations by year
2026: 15 · 2025: 9 · 2024: 12 · 2023: 20 · 2022: 22 · 2021: 26 · 2020: 23 · 2019: 23 · 2018: 13 · 2017: 17 · 2016: 19 · 2015: 18 · 2014: 21 · 2013: 15 · 2012: 3
FWCI
17.76
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Neurogastroenterology & Motility (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
Keywords
diarrhea-predominant irritable bowel syndrome, primary bile acids, fecal bile acids, gut dysbiosis, stool consistency, stool frequency, Escherichia coli, Faecalibacterium prausnitzii, Leptospirillum, Bifidobacterium, lactobacilli
MeSH terms
Adult, Bile Acids and Salts, Colon, Diarrhea, DNA, Bacterial, Feces, Female, Humans, Intestinal Mucosa, Male, Middle Aged, Irritable Bowel Syndrome, Metagenome

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