Low counts of Faecalibacterium prausnitzii in colitis microbiota

Sokol, H.; Seksik, P.; Furet, J. P.; Firmesse, O.; Nion-Larmurier, I.; Beaugerie, L.; Cosnes, J.; Corthier, G.; Marteau, P.; Doré, J.

doi:10.1002/ibd.20903

Cited by 1,275Gut microbiota and healthInflammatory Bowel DiseaseClostridium difficile and Clostridium perfringens research

Low counts of Faecalibacterium prausnitzii in colitis microbiota

Sokol, H., Seksik, P., Furet, J. P., Firmesse, O., Nion-Larmurier, I., Beaugerie, L., Cosnes, J., Corthier, G. +2 more·2009·Inflammatory Bowel Diseases

DOI 10.1002/ibd.20903

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Abstract

BACKGROUND: The intestinal microbiota is suspected to play a role in colitis and particularly in inflammatory bowel disease (IBD) pathogenesis. The aim was to compare the fecal microbiota composition of patients with colitis to that of healthy subjects (HS). METHODS: fecal samples from 22 active Crohn's disease (A-CD) patients, 10 CD patients in remission (R-CD), 13 active ulcerative colitis (A-UC) patients, 4 UC patients in remission (R-UC), 8 infectious colitis (IC) patients, and 27 HS were analyzed by quantitative real-time polymerase chain reaction (PCR) targeting the 16S rRNA gene. Bacterial counts were transformed to logarithms (Log(10) CFU) for statistical analysis. RESULTS: Bacteria of the phylum Firmicutes (Clostridium leptum and Clostridium coccoides groups) were less represented in A-IBD patients (9.7; P = 0.004) and IC (9.4; P = 0.02), compared to HS (10.8). Faecalibacterium prausnitzii species (a major representative of the C. leptum group) had lower counts in A-IBD and IC patients compared to HS (8.8 and 8.3 versus 10.4; P = 0.0004 and P = 0.003). The Firmicutes/Bacteroidetes ratio was lower in A-IBD (1.3; P = 0.0001) and IC patients (0.4; P = 0.002). Compared to HS, Bifidobacteria were less represented in A-IBD and IC (7.9 and 7.7 versus 9.2; P = 0.001 and P = 0.01). CONCLUSIONS: The fecal microbiota of patients with IBD differs from that of HS. The phylum Firmicutes and particularly the species F. prausnitzii, are underrepresented in A-IBD patients as well as in IC patients. These bacteria could be crucial to gut homeostasis since lower counts of F. prausnitzii are consistently associated with a reduced protection of the gut mucosa.

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In IBD, controlling mucosal inflammation with conventional immune-targeting therapy such as corticosteroids prior to FMT may foster the engraftment of taxa adapted to a non-inflammatory environment that can foster mucosal healing.
“In the case of IBD, controlling mucosal inflammation with conventional immune-targeting therapy such as corticosteroids prior to FMT may foster the engraftment of taxa adapted to a non-inflammatory environment that can foster mucosal healing.”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [86]

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Authors: Sokol, H., Seksik, P., Furet, J. P., Firmesse, O., Nion-Larmurier, I., Beaugerie, L., Cosnes, J., Corthier, G., Marteau, P., & Doré, J.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Assistance Publique – Hôpitaux de Paris (FR)
Institut National de la Recherche Agronomique (FR)
ORCID: Sokol, H.
Seksik, P.
Firmesse, O.
Beaugerie, L.
Cosnes, J.
Marteau, P.
Venue: Inflammatory Bowel Diseases
Publisher: Oxford University Press (OUP)
Published: 2009-08
Volume: 15
Issue: 8
Pages: 1183-1189
ISSN: 1078-0998 (ISSN-L)
DOI: 10.1002/ibd.20903
OpenAlex: W2028520715
Cited by: 1,275
References: 44
Citations by year: 2026: 26 · 2025: 60 · 2024: 59 · 2023: 72 · 2022: 107 · 2021: 85 · 2020: 86 · 2019: 80 · 2018: 86 · 2017: 82 · 2016: 102 · 2015: 81 · 2014: 85 · 2013: 78 · 2012: 72
FWCI: 24.80
Type: journal article
Language: en
Open access: closed
Locations: Inflammatory Bowel Diseases (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Keywords: Faecalibacterium prausnitzii, colitis
MeSH terms: Adult, Colitis, Ulcerative, Colon, Crohn Disease, DNA, Bacterial, Feces, Female, Humans, Male, Remission Induction, Colony Count, Microbial, Case-Control Studies, Gram-Positive Bacterial Infections, Ruminococcus

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Low counts of Faecalibacterium prausnitzii in colitis microbiota

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