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Cited by 83

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Lysosome‐associated membrane protein 1 (LAMP‐1) in Alzheimer’s disease

Barrachina, M., Maes, T., Buesa, C., Ferrer, I.·2006·Neuropathology and Applied Neurobiology
DOI 10.1111/j.1365-2990.2006.00756.x
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Abstract

Lysosome‐associated membrane protein 1 (LAMP‐1) is a glycoprotein highly expressed in lysosomal membranes. The present study was initiated to test LAMP‐1 mRNA and protein levels in post mortem frontal cortex (area 8) of Alzheimer’s disease (AD) stages I–IIA/B and stages V–VIC of Braak and Braak, compared with age‐matched controls. TaqMan PCR assays and Western blots demonstrated upregulation of LAMP‐1 mRNA and protein in the cerebral cortex in ADVC. In addition, immunohistochemical studies have shown increased LAMP‐1 immunoreactivity in neurones, and in glial cells surrounding senile plaques, in AD cases. Interestingly, LAMP‐1 immunoreactivity has little correlation with phosphorylated tau deposition and neurofibrillary tangles (NFTs), as neurones with NFTs were rarely LAMP‐1 immunoreactive. In contrast, LAMP‐1 expression was enhanced in neurones with granulovacuolar degeneration. Finally, LAMP‐1 occurred in microglia and multinucleated giant cells in one AD case in whom amyloid burden was cleared following βA‐peptide immunization. These findings support the participation of lysosomes in βA‐amyloid and, probably, in hyperphosphorylated tau turnover in AD.

Overview

Integrity signals

Registry

Crossref · 10.1111/j.1365-2990.2006.00756.x

Cites

4 of 4 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

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  • LAMP1 is mislocalized to dystrophic neurites in 5XFAD models and in human Alzheimer's disease.

    “membrane protein 1 (LAMP1) is mislocalized to dystrophic neurites in 5XFAD models (Forner et al., 2021;Gowrishankar et al., 2015;Wickline et al., 2023) and human AD (Barrachina et al., 2006).”

    From Hippocampal TMEM55B overexpression in the 5XFAD mouse model of Alzheimer's disease (2024) · cites this paper as Barrachina et al., 2006

Citations

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Research works printed but not linked: 16

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  14. Wisniewski HM, 1973, Progress in Neuropathology, 1
  15. 10.1046/j.1471-4159.1997.69052026.x · DOI
  16. 10.1074/jbc.M108161200 · DOI · Paper page

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Metadata

Authors
Barrachina, M., Maes, T., Buesa, C., & Ferrer, I.
Venue
Neuropathology and Applied Neurobiology
Publisher
Wiley
Published
2006-09-15
Volume
32
Issue
5
Pages
505-516
ISSN
  • 0305-1846
  • 1365-2990
DOI
10.1111/j.1365-2990.2006.00756.x
Cited by
83
References
4
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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