The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The ZIM domain mediates homo‐ and heteromeric interactions between Arabidopsis JAZ proteins
Abstract
Summary: Discovery of the jasmonate ZIM‐domain (JAZ) repressors defined the core jasmonate (JA) signalling module as COI1–JAZ–MYC2, and allowed a full view of the JA signalling pathway from hormone perception to transcriptional reprogramming. JAZ proteins are repressors of MYC2 and targets of SCF COI1, which is the likely jasmonate receptor. Upon hormone perception, JAZ repressors are degraded by the proteasome releasing MYC2 and allowing the activation of JA responses. All members of the JAZ family share two conserved domains, the Jas motif, required for JAZ interactions with MYC2 and COI1, and the ZIM domain, the function of which is so far unknown. Here, we show that the ZIM domain acts as a protein–protein interaction domain mediating homo‐ and heteromeric interactions between JAZ proteins. These JAZ–JAZ interactions are independent of the presence of the hormone. The observation that only a few members of the JAZ family form homo‐ and heteromers may suggest the relevance of these proteins in the regulation of JA signalling. Interestingly, the JAZ3ΔJas protein interacts with several JAZ proteins, providing new clues to understanding the dominant JA insensitivity promoted by truncated JAZΔJas proteins. We also provide evidence that the Jas motif mediates the hormone‐dependent interaction between Arabidopsis JAZ3 and COI1, and further confirm that the Jas motif is required and sufficient for Arabidopsis JAZ3–MYC2 interaction. Finally, we show that interaction with MYC2 is a common feature of the JAZ family, as most JAZ proteins can bind MYC2 in pull‐down and yeast two‐hybrid assays.
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Cites
Floral dip: a simplified method forAgrobacterium‐mediated transformation ofArabidopsis thaliana
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Contrasting Mechanisms of Defense Against Biotrophic and Necrotrophic Pathogens
Glazebrook, J. (2005) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.43.040204.135923 · Cited by 4,367
JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling
Thines, B., Katsir, L., Melotto, M., Niu, Y., Mandaokar, A., Liu, G., Nomura, K., He, S. Y., Howe, G. A., & Browse, J. (2007) · Nature · doi:10.1038/nature05960 · Cited by 2,520
The JAZ family of repressors is the missing link in jasmonate signalling
Chini, A., Fonseca, S., Fernández, G., Adie, B., Chico, J. M., Lorenzo, O., García-Casado, G., López-Vidriero, I., Lozano, F. M., Ponce, M. R., et al. (2007) · Nature · doi:10.1038/nature06006 · Cited by 2,432
Self-citationWasternack, C. (2007) · Annals of Botany · doi:10.1093/aob/mcm079 · Cited by 1,835
COI1 : An Arabidopsis Gene Required for Jasmonate-Regulated Defense and Fertility
Xie, D.-X., Feys, B. F., James, S., Nieto-Rostro, M., & Turner, J. G. (1998) · Science · doi:10.1126/science.280.5366.1091 · Cited by 1,655
Lorenzo, O., Piqueras, R., Sánchez-Serrano, J. J., & Solano, R. (2003) · The Plant Cell · doi:10.1105/tpc.007468 · Cited by 1,405
Self-citationCoordinated plant defense responses in Arabidopsis revealed by microarray analysis
Schenk, P. M., Kazan, K., Wilson, I., Anderson, J. P., Richmond, T., Somerville, S. C., & Manners, J. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11655 · Cited by 1,370
Lorenzo, O., Chico, J. M., Saénchez-Serrano, J. J., & Solano, R. (2004) · The Plant Cell · doi:10.1105/tpc.022319 · Cited by 1,344
Self-citationMYC2 Differentially Modulates Diverse Jasmonate-Dependent Functions in Arabidopsis
Dombrecht, B., Xue, G. P., Sprague, S. J., Kirkegaard, J. A., Ross, J. J., Reid, J. B., Fitt, G. P., Sewelam, N., Schenk, P. M., Manners, J. M., et al. (2007) · The Plant Cell · doi:10.1105/tpc.106.048017 · Cited by 1,127
Cited by
Wasternack, C., & Hause, B. (2013) · Annals of Botany · doi:10.1093/aob/mct067 · Cited by 2,629
Kazan, K., & Manners, J. M. (2013) · Molecular Plant · doi:10.1093/mp/sss128 · Cited by 1,081
NINJA connects the co-repressor TOPLESS to jasmonate signalling
Pauwels, L., Barbero, G. F., Geerinck, J., Tilleman, S., Grunewald, W., Pérez, A. C., Chico, J. M., Bossche, R. V., Sewell, J., Gil, E., et al. (2010) · Nature · doi:10.1038/nature08854 · Cited by 1,018
Self-citationThe JAZ Proteins: A Crucial Interface in the Jasmonate Signaling Cascade
Pauwels, L., & Goossens, A. (2011) · The Plant Cell · doi:10.1105/tpc.111.089300 · Cited by 710
Song, S., Qi, T., Huang, H., Ren, Q., Wu, D., Chang, C., Peng, W., Liu, Y., Peng, J., & Xie, D. (2011) · The Plant Cell · doi:10.1105/tpc.111.083089 · Cited by 608
Metadata
- Authors
- Chini, A., Fonseca, S., Chico, J. M., Fernández‐Calvo, P., & Solano, R.
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2009-06-25
- Volume
- 59
- Issue
- 1
- Pages
- 77-87
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W2026841737
- Cited by
- 306
- References
- 46
- FWCI
- 21.54
- Type
- journal article
- Language
- en
- Open access
- closed
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