The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
The basic helix‐loop‐helix transcription factor CrMYC2 controls the jasmonate‐responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus
Open accessAbstract
Summary: Jasmonates are plant signalling molecules that play key roles in defence against insects and certain pathogens, among others by controlling the biosynthesis of protective secondary metabolites. In Catharanthus roseus, the AP2/ERF‐domain transcription factor ORCA3 controls the jasmonate‐responsive expression of several genes encoding enzymes involved in terpenoid indole alkaloid biosynthesis. ORCA3 gene expression is itself induced by jasmonate. The ORCA3 promoter contains an autonomous jasmonate‐responsive element (JRE) composed of a quantitative sequence responsible for the high level of expression and a qualitative sequence that acts as an on/off switch in response to methyl‐jasmonate (MeJA). Here, we identify the basic helix‐loop‐helix (bHLH) transcription factor CrMYC2 as the major activator of MeJA‐responsive ORCA3 gene expression. The CrMYC2 gene is an immediate‐early jasmonate‐responsive gene. CrMYC2 binds to the qualitative sequence in the ORCA3 JRE in vitro, and transactivates reporter gene expression via this sequence in transient assays. Knock‐down of the CrMYC2 expression level via RNA interference caused a strong reduction in the level of MeJA‐responsive ORCA3 mRNA accumulation. In addition, MeJA‐responsive expression of the related transcription factor gene ORCA2 was significantly reduced. Our results show that MeJA‐responsive expression of alkaloid biosynthesis genes in C. roseus is controlled by a transcription factor cascade consisting of the bHLH protein CrMYC2 regulating ORCA gene expression, and the AP2/ERF‐domain transcription factors ORCA2 and ORCA3, which in turn regulate a subset of alkaloid biosynthesis genes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling
Thines, B., Katsir, L., Melotto, M., Niu, Y., Mandaokar, A., Liu, G., Nomura, K., He, S. Y., Howe, G. A., & Browse, J. (2007) · Nature · doi:10.1038/nature05960 · Cited by 2,520
The JAZ family of repressors is the missing link in jasmonate signalling
Chini, A., Fonseca, S., Fernández, G., Adie, B., Chico, J. M., Lorenzo, O., García-Casado, G., López-Vidriero, I., Lozano, F. M., Ponce, M. R., et al. (2007) · Nature · doi:10.1038/nature06006 · Cited by 2,432
ICE1: a regulator of cold-induced transcriptome and freezing tolerance in Arabidopsis
Chinnusamy, V., Ohta, M., Kanrar, S., Lee, B.-H., Hong, X., Agarwal, M., & Zhu, J.-K. (2003) · Genes & Development · doi:10.1101/gad.1077503 · Cited by 1,673
Construct design for efficient, effective and high‐throughput gene silencing in plants
Wesley, S. V., Helliwell, C. A., Smith, N. A., Wang, M., Rouse, D. T., Liu, Q., Gooding, P. S., Singh, S. P., Abbott, D., Stoutjesdijk, P. A., et al. (2001) · The Plant Journal · doi:10.1046/j.1365-313x.2001.01105.x · Cited by 1,532
Lorenzo, O., Chico, J. M., Saénchez-Serrano, J. J., & Solano, R. (2004) · The Plant Cell · doi:10.1105/tpc.022319 · Cited by 1,344
Solano, R., Stepanova, A., Chao, Q., & Ecker, J. R. (1998) · Genes & Development · doi:10.1101/gad.12.23.3703 · Cited by 1,287
Turner, J. G., Ellis, C., & Devoto, A. (2002) · The Plant Cell · doi:10.1105/tpc.000679 · Cited by 1,157
Transcriptional regulation and transformation by Myc proteins
Adhikary, S., & Eilers, M. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1703 · Cited by 1,131
MYC2 Differentially Modulates Diverse Jasmonate-Dependent Functions in Arabidopsis
Dombrecht, B., Xue, G. P., Sprague, S. J., Kirkegaard, J. A., Ross, J. J., Reid, J. B., Fitt, G. P., Sewelam, N., Schenk, P. M., Manners, J. M., et al. (2007) · The Plant Cell · doi:10.1105/tpc.106.048017 · Cited by 1,127
Jasmonic acid is a signal transducer in elicitor-induced plant cell cultures.
Gundlach, H., Müller, M. J., Kutchan, T. M., & Zenk, M. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.6.2389 · Cited by 1,117
Cited by
Wasternack, C., & Hause, B. (2013) · Annals of Botany · doi:10.1093/aob/mct067 · Cited by 2,629
Kazan, K., & Manners, J. M. (2013) · Molecular Plant · doi:10.1093/mp/sss128 · Cited by 1,081
Jan, R., Asaf, S., Numan, M., Lubna, & Kim, K.-M. (2021) · Agronomy · doi:10.3390/agronomy11050968 · Cited by 832
Evolution of Hormone Signaling Networks in Plant Defense
Berens, M. L., Berry, H. M., Mine, A., Argueso, C. T., & Tsuda, K. (2017) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-080516-035544 · Cited by 563
Yu, Z.-X., Li, J.-X., Yang, C.-Q., Hu, W.-L., Wang, L.-J., & Chen, X.-Y. (2012) · Molecular Plant · doi:10.1093/mp/ssr087 · Cited by 481
Metadata
- Authors
- Zhang, H., Hedhili, S., Montiel, G., Zhang, Y., Chatel, G., Pré, M., Gantet, P., & Memelink, J.
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2011-04-26
- Volume
- 67
- Issue
- 1
- Pages
- 61-71
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W2139648297
- Cited by
- 353
- References
- 34
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The basic helix‐loop‐helix transcription factor CrMYC2 controls the jasmonate‐responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus. https://app.cochat.ai/papers/10.1111/j.1365-313x.2011.04575.x
- The paper
- Zhang, H., Hedhili, S., Montiel, G., Zhang, Y., Chatel, G., Pré, M., Gantet, P., & Memelink, J. (2011). The basic helix‐loop‐helix transcription factor CrMYC2 controls the jasmonate‐responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus. The Plant Journal. https://doi.org/10.1111/j.1365-313x.2011.04575.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
