The canine hair cycle – a guide for the assessment of morphological and immunohistochemical criteria
Open accessAbstract
The hair follicle has a lifelong capacity to cycle through recurrent phases of controlled growth (anagen), regression (catagen) and quiescence (telogen), each associated with specific morphological changes. A comprehensive classification scheme is available for mice to distinguish the cycle stages anagen I-VI, catagen I-VIII and telogen. For dogs, such a classification system does not exist, although alopecia associated with hair cycle arrest is common. We applied analogous morphological criteria and various staining techniques to subdivide the canine hair cycle stages to the same extent as has been done in mice. Of all the staining techniques applied, haematoxylin and eosin stain, Sacpic, Masson Fontana and immunohistochemistry for vimentin and laminin proved to be most useful. To evaluate the applicability of our criteria, we investigated skin biopsies from healthy beagle dogs (n=20; biopsies from shoulder and thigh) kept in controlled conditions. From each biopsy, at least 50 hair follicles were assessed. Statistical analysis revealed that 30% of the follicles were in anagen (12% early and 18% late), 8% in catagen (2% early, 5% late and 1% not determinable) and 27% in telogen. Thirty-five per cent of hair follicles could not be assigned to a specific cycle stage because not all follicles within one biopsy were oriented perfectly. In conclusion, this guide will not only be helpful for the investigation of alopecic disorders and possibly their pathogenesis, but may also serv…
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Dogs differ from the synchronized and mosaic hair-cycle categories, although hair loss associated with hair cycle arrest is seen.
“Dogs differ from these categories, although hair loss associated with hair cycle arrest is seen33, 36, 37.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [37]
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- Authors
- Müntener, T., Doherr, M. G., Guscetti, F., Suter, M. M., & Welle, M. M.
- Affiliations
- University of Bern (CH)
- University of Zurich (CH)
- Corresponding author
- Welle, Monika M.
- Venue
- Veterinary Dermatology
- Publisher
- Wiley
- Published
- 2011-03-14
- Volume
- 22
- Issue
- 5
- Pages
- 383-395
- ISSN
- 0959-4493 (ISSN-L)
- 1365-3164
- OpenAlex
- W1596237853
- Cited by
- 43
- References
- 20
- Citations by year
- 2026: 4 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 8 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- Locations
- Veterinary Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- BORIS (University Library Bern) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- hair follicle, anagen, catagen, telogen, hair loss, vimentin, laminin, immunohistochemistry, H&E staining, beagle dogs, skin biopsy
- MeSH terms
- Animals, Cell Cycle, Dogs, Female, Immunohistochemistry, Male, Staining and Labeling, Hair Follicle
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