Acne treatment by methyl aminolevulinate photodynamic therapy with red light vs. intense pulsed light
Abstract
Various methods of photodynamic therapy (PDT) for acne have been introduced. However, comparative studies among them are still needed. We performed this study to compare the effect of methyl aminolevulinate (MAL) PDT for acne between red light and intense pulsed light (IPL). Twenty patients were enrolled in this eight‐week, prospective, split‐face study. We applied MAL cream over the whole face with a three‐hour incubation time. Then patients were irradiated with 22 J/cm 2 of red light on one‐half of the face and 8–10 J/cm 2 of IPL on the other half during each treatment session. We performed three treatment sessions at two‐week intervals and followed‐up patients until four weeks after the last session. Inflammatory and non‐inflammatory acne lesions were reduced significantly on both sides. The red light side showed a better response than the IPL side after the first treatment. Serious adverse effects after treatment were not observed. MAL‐PDT with red light and IPL are both an effective and safe modality in acne treatment. Red light showed a faster response time than IPL. After multiple sessions, both light sources demonstrated satisfactory results. We suggest that reducing the total dose of red light is desirable when performing MAL‐PDT in Asian patients with acne compared with Caucasians.
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For the treatment of acne, the total dose of red light needs to be adjusted for FST.
“For the treatment of acne, the total dose of red light needs to be adjusted for FST as discussed by multiple authors for patients of Asian origin.65,118–120”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [65]
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- Authors
- Hong, J. S., Jung, J. Y., Yoon, J. Y., & Suh, D. H.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Suh, Dae Hun
- Venue
- International Journal of Dermatology
- Publisher
- Wiley
- Published
- 2012-10-09
- Volume
- 52
- Issue
- 5
- Pages
- 614-619
- ISSN
- 0011-9059 (ISSN-L)
- 1365-4632
- OpenAlex
- W1962923008
- Cited by
- 50
- References
- 16
- Citations by year
- 2025: 5 · 2024: 6 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 9 · 2016: 7 · 2015: 7 · 2014: 2 · 2013: 1
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- acne, methyl aminolevulinate, photodynamic therapy, red light, intense pulsed light, split-face comparison, inflammatory acne lesions, non-inflammatory acne lesions, treatment response time, adverse effects, Asian patients
- MeSH terms
- Acne Vulgaris, Adult, Aminolevulinic Acid, Color, Female, Humans, Male, Pain, Photochemotherapy, Photosensitizing Agents, Young Adult, Intense Pulsed Light Therapy
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