The DOI matches its Crossref record; 204 of the 204 references it cites were found in a registry or an index.
REVIEW: Behavioural assessment of drug reinforcement and addictive features in rodents: an overview
Abstract
Some psychoactive drugs are abused because of their ability to act as reinforcers. As a consequence behavioural patterns (such as drug‐seeking/drug‐taking behaviours) are promoted that ensure further drug consumption. After prolonged drug self‐administration, some individuals lose control over their behaviour so that these drug‐seeking/taking behaviours become compulsive, pervading almost all life activities and precipitating the loss of social compatibility. Thus, the syndrome of addictive behaviour is qualitatively different from controlled drug consumption. Drug‐induced reinforcement can be assessed directly in laboratory animals by either operant or non‐operant self‐administration methods, by classical conditioning‐based paradigms such as conditioned place preference or sign tracking, by facilitation of intracranial electric self‐stimulation, or, alternatively by drug‐induced memory enhancement. In contrast, addiction cannot be modelled in animals, at least as a whole, within the constraints of the laboratory. However, various procedures have been proposed as possible rodent analogues of addiction’s major elements including compulsive drug seeking, relapse, loss of control/impulsivity, and continued drug consumption despite negative consequences. This review provides an extensive overview and a critical evaluation of the methods currently used for studying drug‐induced reinforcement as well as specific features of addictive behaviour. In addition, comic strips that illustrate behavioural methods used in the drug abuse field are provided given for free download under http://www.zi‐mannheim/psychopharmacology.de
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“Addiction as a behavioral phenomenon is complex and has several components or phases, including drug consumption, reinforcement learning, drug seeking, relapse, tolerance, and withdrawal (Sanchis-Segura and Spanagel 2006).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Sanchis-Segura and Spanagel 2006
In the citing paper
“a wide range of paradigms have been developed that model individual features of addiction behavior (Sanchis-Segura and Spanagel 2006).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Sanchis-Segura and Spanagel 2006
Citations
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“Addiction, however, is a much more restricted phenomenon with a prevalence of not higher than 10% of the total population (Bechara 2005; Li & Volkow 2005).”
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Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340
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“Addiction as a behavioral phenomenon is complex and has several components or phases, including drug consumption, reinforcement learning, drug seeking, relapse , tolerance, and withdrawal (Sanchis-Segura and Spanagel 2006).”
Metadata
- Authors
- Sanchis‐Segura, C., & Spanagel, R.
- Affiliations
- Central Institute of Mental Health (DE)
- Corresponding author
- Sanchis‐Segura, Carles
- Venue
- Addiction Biology
- Publisher
- Wiley
- Published
- 2006-03
- Volume
- 11
- Issue
- 1
- Pages
- 2-38
- ISSN
- 1355-6215 (ISSN-L)
- 1369-1600
- OpenAlex
- W2071761663
- Cited by
- 629
- References
- 204
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 19 · 2023: 29 · 2022: 20 · 2021: 25 · 2020: 34 · 2019: 26 · 2018: 30 · 2017: 29 · 2016: 39 · 2015: 45 · 2014: 39 · 2013: 41 · 2012: 40
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Addiction Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- drug reinforcement, addictive behavior, self-administration, drug-seeking behavior, compulsive drug seeking, relapse, impulsivity, conditioned place preference, sign-tracking, intracranial self-stimulation
- MeSH terms
- Alcoholism, Animals, Association Learning, Behavior, Animal, Conditioning, Psychological, Disease Models, Animal, Models, Psychological, Motivation, Reinforcement Schedule, Reward, Rodentia, Self Stimulation, Substance Withdrawal Syndrome, Wit and Humor as Topic, Substance-Related Disorders
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