The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cytokines Cause Functional and Structural Damage to Isolated Islets of Langerhans
Abstract
Cytokines are soluble, antigen non‐specific, non‐immunoglobulin mediators produced and secreted by blood mononuclear cells interacting in the cellular immune‐response. To test the possibility that cytokines participate in the autoimmune destruction of the pancreatic beta‐cells leading to insulin‐dependent diabetes mellitus, isolated human or rat islets of Langerhans were incubated for 7 days with cytokine‐rich, cell‐free supernatants of blood mononuclear cells from healthy human donors stimulated with or without purified protein derivative of tuberculin or phytohaemagglutinin. Glucose stimulated insulin‐release, and contents of insulin and glucagon in islets incubated with cytokine‐rich supernatants were markedly reduced. This impairment of islet function was due to a cytotoxic effect of cytokine‐rich supernatants as judged by disintegration of normal light‐microscopic morphology.
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Citations
Cites
ISLET-CELL ANTIBODIES IN DIABETES MELLITUS WITH AUTOIMMUNE POLYENDOCRINE DEFICIENCIES
Bottazzo, G., Florin-Christensen, A., & Doniach, D. (1974) · The Lancet · doi:10.1016/s0140-6736(74)90140-8 · Cited by 1,469
Cited by
Eisenbarth (1986) · doi:10.1056/nejm198605223142106 · Cited by 1,659
Interferons induce an antiviral state in human pancreatic islet cells
Hultcrantz, M., Hühn, M. H., Wolf, M., Olsson, A., Jacobson, S., Williams, B. R., Korsgren, O., & Flodström-Tullberg, M. (2007) · Virology · doi:10.1016/j.virol.2007.05.010 · Cited by 98
β-Cell Responses to Nitric Oxide
Broniowska, K. A., Oleson, B. J., & Corbett, J. A. (2014) · Vitamins & Hormones · doi:10.1016/b978-0-12-800174-5.00012-0 · Cited by 48
Park, C., Kim, J.-R., Shim, J.-K., Kang, B.-S., Park, Y.-G., Nam, K.-S., Lee, Y.-C., & Kim, C.-H. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.1004 · Cited by 47
Metadata
- Authors
- Mandrup‐Poulsen, T., Bendtzen, K., Nielsen, J. H., Bendixen, G., & Nerup, J.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 1985-08
- Volume
- 40
- Issue
- 6
- Pages
- 424-429
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W2080837475
- Cited by
- 180
- References
- 1
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Mandrup‐Poulsen, T., Bendtzen, K., Nielsen, J. H., Bendixen, G., & Nerup, J. (1985). Cytokines Cause Functional and Structural Damage to Isolated Islets of Langerhans. Allergy. https://doi.org/10.1111/j.1398-9995.1985.tb02681.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
