The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Cytomegalovirus in transplantation – challenging the status quo
Abstract
Abstract: Background: Cytomegalovirus (CMV) infection of solid organ transplant (SOT) recipients causes both ‘‘direct’’ and ‘‘indirect’’ effects including allograft rejection, decreased graft and patient survival, and predisposition to opportunistic infections and malignancies. Options for CMV prevention include pre‐emptive therapy, whereby anti‐CMV agents are administered based on sensitive viral assays, or universal prophylaxis of all at‐risk patients. Each approach has advantages and disadvantages in terms of efficacy, costs, and side effects. Standards of care for prophylaxis have not been established. Methods: A committee of international experts was convened to review the available data regarding CMV prophylaxis and to compare preventative strategies for CMV after transplantation from seropositive donors or in seropositive recipients. Results: Pre‐emptive therapy requires frequent monitoring with subsequent treatment of disease and associated costs, while universal prophylaxis results in greater exposure to potential toxicities and costs of drugs. The advantages of prophylaxis include suppressing asymptomatic viremia and prevention of both direct and indirect effects of CMV infection. Meta analyses reveal decreased in mortality for patients receiving CMV prophylaxis. Costs associated with prophylaxis are less than for routine monitoring and pre‐emptive therapy. The optimal duration of antiviral prophylaxis remains undefined. Extended prophylaxis may improve clinical outcomes in the highest‐risk patient populations including donor‐seropositive/recipient‐seronegative renal transplants and in CMV‐infected lung and heart transplantation. Conclusions: Prophylaxis is beneficial in preventing direct and indirect effects of CMV infection in transplant recipients, affecting both allograft and patient survival. More studies are necessary to define optimal prophylaxis regimens.
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Citations
Cites
Infection in Organ-Transplant Recipients
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Self-citationPaya, C., Humar, A., Dominguez, E., Washburn, K., Blumberg, E., Alexander, B., Freeman, R., Heaton, N., & Pescovitz, M. D. (2004) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00382.x · Cited by 880
Self-citationHuman cytomegalovirus infection and expression in human malignant glioma.
Cobbs, C., Harkins, L. E., Samanta, M., Gillespie, G. Y., Bharara, S., King, P. H., Nabors, B., Cobbs, C. G., & Britt, W. J. (2002) · PubMed · Cited by 717
Valacyclovir for the Prevention of Cytomegalovirus Disease after Renal Transplantation
Lowance, D., Neumayer, H.-H., Legendre, C. M., Squifflet, J.-P., Kovarik, J., Brennan, P. J., Norman, D., Mendez, R., Keating, M. R., Coggon, G. L., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199905133401903 · Cited by 712
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Valganciclovir Results in Improved Oral Absorption of Ganciclovir in Liver Transplant Recipients
Pescovitz, M. D., Rabkin, J., Merion, R. M., Paya, C. V., Pirsch, J., Freeman, R. B., O'Grady, J., Robinson, C., To, Z., Wren, K., et al. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.10.2811-2815.2000 · Cited by 357
Self-citationHodson, E. M., Jones, C. A., Webster, A. C., Strippoli, G. F., Barclay, P. G., Kable, K., Vimalachandra, D., & Craig, J. C. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66553-1 · Cited by 350
Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer
Harkins, L., Volk, A. L., Samanta, M., Mikolaenko, I., Britt, W. J., Bland, K. I., & Cobbs, C. S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11524-8 · Cited by 346
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Cited by
Lopez-Vergès, S., Milush, J. M., Schwartz, B. S., Pando, M. J., Jarjoura, J., York, V. A., Houchins, J. P., Miller, S., Kang, S.-M., Norris, P. J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110900108 · Cited by 822
Temporal Response of the Human Virome to Immunosuppression and Antiviral Therapy
De Vlaminck, I., Khush, K. K., Strehl, C., Kohli, B., Luikart, H., Neff, N. F., Okamoto, J., Snyder, T. M., Cornfield, D. N., Nicolls, M. R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.034 · Cited by 471
Manifestations of Human Cytomegalovirus Infection: Proposed Mechanisms of Acute and Chronic Disease
Britt, W. (2008) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-540-77349-8_23 · Cited by 345
Coordinated expansion of both memory T cells and NK cells in response to CMV infection in humans
Bayard, C., Lepetitcorps, H., Roux, A., Larsen, M., Fastenackels, S., Salle, V., Vieillard, V., Marchant, A., Stern, M., Boddaert, J., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201546179 · Cited by 65
Cantisán, S., Torre-Cisneros, J., Lara, R., Rodríguez-Benot, A., Santos, F., Gutiérrez-Aroca, J., Gayoso, I., González-Padilla, M., Casal, M., Rivero, A., et al. (2009) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00214-09 · Cited by 27
Self-citation
Metadata
- Authors
- Fishman, J. A., Emery, V., Freeman, R., Pascual, M., Rostaing, L., Schlitt, H. J., Sgarabotto, D., Torre‐Cisneros, J., & Uknis, M. E.
- Venue
- Clinical Transplantation
- Publisher
- Wiley
- Published
- 2007-03
- Volume
- 21
- Issue
- 2
- Pages
- 149-158
- ISSN
- 0902-0063 (ISSN-L)
- 1399-0012
- OpenAlex
- W2026145100
- Cited by
- 289
- References
- 30
- FWCI
- 13.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fishman, J. A., Emery, V., Freeman, R., Pascual, M., Rostaing, L., Schlitt, H. J., Sgarabotto, D., Torre‐Cisneros, J., & Uknis, M. E. (2007). Cytomegalovirus in transplantation – challenging the status quo. Clinical Transplantation. https://doi.org/10.1111/j.1399-0012.2006.00618.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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