Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [ 99m Tc] TRODAT‐1
Abstract
Chang TT, Yeh TL, Chiu NT, Chen PS, Huang HY, Yang YK, Lee IH, Lu RB. Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [ 99m Tc] TRODAT‐1. Bipolar Disord 2010: 12: 102–106. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S. Objectives: Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients. Methods: Seventeen drug‐free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [ 99m Tc] TRODAT‐1. Results: Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT. Conclusions: Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chang and colleagues reported that unmedicated euthymic subjects with bipolar disorder had significantly relatively higher whole striatal DAT binding.
“Chang and colleagues [284] reported that unmedicated euthymic subjects with bipolar disorder had significantly relatively higher whole striatal DAT binding”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [284]
Cites
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
Endicott, J. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770310043002 · Cited by 5,686 · see citing works
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476 · see citing works
Profound neuronal plasticity in response to inactivation of the dopamine transporter.
Jones, S., Gainetdinov, R., Jaber, M., Giros, B., Wightman, R., & Caron, M. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.7.4029 · Cited by 729 · see citing works
Stahl, S. M. (2000) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v61n0103 · Cited by 490 · see citing works
The Increasing Medical Burden in Bipolar Disorder
Kupfer, D. J. (2005) · JAMA · doi:10.1001/jama.293.20.2528 · Cited by 489 · see citing works
Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder
Berk, M., Dodd, S., Kauer‐Sant’Anna, M., Malhi, G. S., Bourin, M., Kapczinski, F., & Norman, T. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.01058.x · Cited by 396 · see citing works
Pramipexole for bipolar II depression: a placebo-controlled proof of concept study
Zarate, C. A., Payne, J. L., Singh, J. B., Quiroz, J. A., Luckenbaugh, D. A., Denicoff, K. D., Charney, D. S., & Manji, H. K. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.03.013 · Cited by 342 · see citing works
Fon, E. A., Pothos, E. N., Sun, B.-C., Killeen, N. P., Sulzer, D. L., & Edwards, R. H. (1997) · Neuron · doi:10.1016/s0896-6273(00)80418-3 · Cited by 337 · see citing works
Co-morbidity and familial aggregation of alcoholism and anxiety disorders
Merikangas, K. R., Stevens, D. E., Fenton, B. T., Stolar, M. J., O’Malley, S. S., Woods, S. W., & RISCH, N. J. (1998) · Psychological Medicine · doi:10.1017/s0033291798006941 · Cited by 301 · see citing works
A Preliminary fMRI Study of Sustained Attention in Euthymic, Unmedicated Bipolar Disorder
Strakowski, S. M., Adler, C. M., Holland, S. K., Mills, N., & DelBello, M. P. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300492 · Cited by 242 · see citing works
The dopamine transporter: A crucial component regulating dopamine transmission
Jaber, M., Jones, S. R., Bruno Giros, A., & Caron, M. G. (1997) · Movement Disorders · doi:10.1002/mds.870120502 · Cited by 232 · see citing works
Fronto-Striatal Overactivation in Euthymic Bipolar Patients During an Emotional Go/NoGo Task
Wessa, M., Houenou, J., Paillère-Martinot, M.-L., Berthoz, S., Artiges, E., Leboyer, M., & Martinot, J.-L. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.4.638 · Cited by 225 · see citing works
Brain SPECT Imaging of Amphetamine-Induced Dopamine Release in Euthymic Bipolar Disorder Patients
Anand, A., Verhoeff, P., Seneca, N., Zoghbi, S. S., Seibyl, J. P., Charney, D. S., & Innis, R. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1108 · Cited by 222 · see citing works
The role of dopamine in mood disorders
Diehl, D. J., & Gershon, S. (1992) · Comprehensive Psychiatry · doi:10.1016/0010-440x(92)90007-d · Cited by 216 · see citing works
Strakowski, S. M., Adler, C. M., Holland, S. K., Mills, N. P., DelBello, M. P., & Eliassen, J. C. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.9.1697 · Cited by 209 · see citing works
Henry, J., & Scherman, D. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90082-8 · Cited by 165 · see citing works
Yatham, L. N., Liddle, P. F., Shiah, I.-S., Lam, R. W., Ngan, E., Scarrow, G., Imperial, M., Stoessl, J., Sossi, V., & Ruth, T. J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.768 · Cited by 122 · see citing works
Chen, P. S., Yang, Y. K., Yeh, T. L., Lee, I., Yao, W. J., Chiu, N.-T., & Lu, R. B. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.11.007 · Cited by 101 · see citing works
Self-citationBorght, T. M. V., Sima, A. A. F., Kilbourn, M. R., Desmond, T. J., Kuhl, D. E., & Frey, K. A. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00167-h · Cited by 99 · see citing works
The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD)
Madras, B. K., Miller, G. M., & Fischman, A. J. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00439-9 · Cited by 97 · see citing works
Zubieta, J., Taylor, S., Huguelet, P., Koeppe, R., Kilbourn, M., & Frey, K. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00981-1 · Cited by 81 · see citing works
Yatham, L., Liddle, P., Lam, R. W., Shiah, I., Lane, C. J., Stoessl, A., Sossi, V., & Ruth, T. J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1718 · Cited by 80 · see citing works
Reproducibility of 99mTc-TRODAT-1 SPECT measurement of dopamine transporters in Parkinson's disease.
Hwang, W. J., Yao, W., Wey, S., & Ting, G. (2004) · PubMed · Cited by 79 · see citing works
Horschitz, S., Hummerich, R., Lau, T., Rietschel, M., & Schloss, P. D. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001730 · Cited by 64 · see citing works
Lu, W., & Wolf, M. E. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00136-8 · Cited by 61 · see citing works
Atypical Antipsychotics for Bipolar Disorder
Yatham, L. N. (2005) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2005.01.001 · Cited by 47 · see citing works
Mick, E., Kim, J.-W., Biederman, J., Wozniak, J., Wilens, T., Spencer, T., Smoller, J. W., & Faraone, S. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30745 · Cited by 44 · see citing works
Minton, G. O., Young, A. H., McQuade, R., Fairchild, G. F., Ingram, C. D., & Gartside, S. E. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.53 · Cited by 32 · see citing works
Swann, A. C. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.2.177 · Cited by 22 · see citing works
Neurochemical brain imaging studies in bipolar disorder
Yatham, L. N., & Malhi, G. S. (2003) · Acta Neuropsychiatrica · doi:10.1046/j.1601-5215.2003.00053.x · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ashok, A. H., Marques, T. R., Jauhar, S., Nour, M. M., Goodwin, G. M., Young, A. H., & Howes, O. D. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.16 · Cited by 546 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Anand, A., Barkay, G., Dzemidzic, M., Albrecht, D., Karne, H., Zheng, Q.-H., Hutchins, G. D., Normandin, M. D., & Yoder, K. K. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00936.x · Cited by 139 · see citing works
- Authors
- Chang, T. T., Yeh, T. L., Chiu, N. T., Chen, P. S., Huang, H. Y., Yang, Y. K., Lee, I. H., & Lu, R. B.
- Affiliations
- E-Da Hospital (TW)
- National Cheng Kung University (TW)
- Corresponding author
- Chen, Po See
- Yang, Yen Kuang
- Venue
- Bipolar Disorders
- Publisher
- Wiley
- Published
- 2010-01-24
- Volume
- 12
- Issue
- 1
- Pages
- 102-106
- ISSN
- 1398-5647 (ISSN-L)
- 1399-5618
- OpenAlex
- W2112516721
- Cited by
- 63
- References
- 31
- Citations by year
- 2026: 2 · 2025: 2 · 2022: 4 · 2021: 25 · 2020: 3 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 1 · 2012: 5
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bipolar Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- bipolar disorder, striatal dopamine transporter, dopamine transporter availability, euthymic state, 99mTc-TRODAT-1, dopamine
- MeSH terms
- Adult, Bipolar Disorder, Corpus Striatum, Female, Humans, Male, Tropanes, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Radiopharmaceuticals, Dopamine Plasma Membrane Transport Proteins, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
