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Cited by 122Bipolar Disorder and TreatmentSchizophrenia research and treatmentTreatment of Major Depression

PET Study of [18F]6-Fluoro-l-Dopa Uptake in Neuroleptic- and Mood-Stabilizer-Naive First-Episode Nonpsychotic Mania: Effects of Treatment With Divalproex Sodium

Yatham, Lakshmi N., Liddle, Peter F., Shiah, I-Shin, Lam, Raymond W., Ngan, Elton, Scarrow, Gayle, Imperial, Miguel, Stoessl, Jon +2 more·2002·American Journal of Psychiatry
DOI 10.1176/appi.ajp.159.5.768
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Abstract

OBJECTIVE: Although dopaminergic hyperactivity has been implicated in mania, the precise location in the brain of the abnormality is unclear. This study assessed presynaptic dopamine function in neuroleptic- and mood-stabilizer-naive nonpsychotic first-episode manic patients before and after treatment with divalproex sodium by measuring [(18)F]6-fluoro-L-dopa ([(18)F]DOPA) uptake in the striatum with positron emission tomography (PET). METHOD: Thirteen patients with DSM-IV bipolar I disorder, manic episode, and 13 healthy comparison subjects underwent [(18)F]DOPA PET scans. Ten of the 13 patients had repeat PET scans 2-6 weeks after beginning treatment with divalproex sodium monotherapy. [(18)F]DOPA uptake rate constants (K(i) values) in the striatum were calculated by using graphical analysis with activity from the occipital cortex as the input function. RESULTS: No significant differences in [(18)F]DOPA uptake rate constants in the striatum were found between the manic patients and the comparison subjects. After treatment with divalproex sodium, [(18)F]DOPA rate constants were significantly reduced in the patients and were lower in the patients than in the comparison subjects. CONCLUSIONS: Although presynaptic dopamine function as reflected by [(18)F]DOPA uptake is not altered in mania, presynaptic dopamine function in manic patients was lower after treatment with divalproex sodium.

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Crossref · 10.1176/appi.ajp.159.5.768

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  • The presence of psychosis may moderate patterns of DA receptor binding; striatal D2 receptor signaling seems greater in psychotic patients with bipolar disorder, whereas no differences in D2 availability were found between non-psychotic patients with bipolar disorder and controls.

    “There is also evidence that the presence of psychosis may moderate patterns of DA receptor binding. Specifically, striatal D2 receptor signaling seems to be greater in psychotic patients with bipolar disorder [286,287], whereas no differences in D2 availability were found between non-psychotic patients with bipolar disorder and controls [288,289].”

    From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [289]

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Authors
Yatham, L. N., Liddle, P. F., Shiah, I.-S., Lam, R. W., Ngan, E., Scarrow, G., Imperial, M., Stoessl, J., Sossi, V., & Ruth, T. J.
Affiliations
University of British Columbia (CA)
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
2002-05-01
Volume
159
Issue
5
Pages
768-774
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/appi.ajp.159.5.768
OpenAlex
W2156766604
Cited by
122
References
58
Citations by year
2024: 1 · 2022: 1 · 2021: 26 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 8 · 2013: 3 · 2012: 4
FWCI
3.84
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
first-episode mania, divalproex sodium, striatal dopamine uptake, bipolar I disorder, neuroleptic-naive patients
MeSH terms
Adult, Age Factors, Anticonvulsants, Bipolar Disorder, Corpus Striatum, Dihydroxyphenylalanine, Dopamine, Female, Fluorine Radioisotopes, Humans, Male, Middle Aged, Tomography, Emission-Computed, Antipsychotic Agents, Valproic Acid

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