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Cited by 204

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

The Purine‐Nucleotide Cycle: Comparison of the Levels of Citric Acid Cycle Intermediates with the Operation of the Purine Nucleotide Cycle in Rat Skeletal Muscle during Exercise and Recovery from Exercise

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ARAGÓN, Juan J., LOWENSTEIN, John M.·1980·European Journal of Biochemistry
DOI 10.1111/j.1432-1033.1980.tb04877.x
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Abstract

The contents of citric acid cycle compounds were measured in rat hind limb muscle in situ during rest, exercise, and recovery from exercise. The following changes in citric acid cycle intermediates were observed during exercise for 15 min. The contents of fumarate and malate increased fourfold over resting values. The contents of citrate, isocitrate, and succinate rose 68%, 48% and 87% respectively, but the increase in these intermediates was delayed relative to the increase in fumarate and malate. The content of 2‐oxoglutarate did not change significantly. The content of oxaloacetate increased from less than 1 nmol/g dry weight in resting muscle to 8 nmol/g dry weight during exercise. The orthophosphate content doubled. The sum of the contents of citric acid cycle intermediates doubled. The ratios of the contents of malate/fumarate and citrate/isocitrate remained constant. The constancy of the citrate/isocitrate ratio indicates that the concentration of intra‐cellular free Mg 2+ is not affected by exercise. All metabolite levels returned to resting values during recovery. Comparison of these data with the rate of operation of the purine nucleotide cycle leads us to conclude that the increase in citric acid cycle intermediates can be accounted for by the operation of the purine nucleotide cycle.

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Metadata

Authors
ARAGÓN, J. J., & LOWENSTEIN, J. M.
Venue
European Journal of Biochemistry
Publisher
Wiley
Published
1980-09
Volume
110
Issue
2
Pages
371-377
ISSN
  • 0014-2956 (ISSN-L)
  • 1432-1033
DOI
10.1111/j.1432-1033.1980.tb04877.x
OpenAlex
W1597264042
Cited by
204
References
3
FWCI
18.45
Type
journal article
Language
en
Open access
bronze
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8949 d)

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CoChat. (2026). Citation check: The Purine‐Nucleotide Cycle: Comparison of the Levels of Citric Acid Cycle Intermediates with the Operation of the Purine Nucleotide Cycle in Rat Skeletal Muscle during Exercise and Recovery from Exercise. https://app.cochat.ai/papers/10.1111/j.1432-1033.1980.tb04877.x
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ARAGÓN, J. J., & LOWENSTEIN, J. M. (1980). The Purine‐Nucleotide Cycle: Comparison of the Levels of Citric Acid Cycle Intermediates with the Operation of the Purine Nucleotide Cycle in Rat Skeletal Muscle during Exercise and Recovery from Exercise. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1980.tb04877.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.