Metabolic signatures of exercise in human plasma
Open accessAbstract
Measurement by mass spectrometry of 200 blood metabolites reveals that individuals who are more fit respond more effectively to exercise, as shown by larger exercise-induced increase in glycerol.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Endurance exercise decreased succinate, malate, hypoxanthine, and xanthine.
“Interestingly, several well‐established accumulation signatures of succinate, malate, hypoxanthine, and xanthine induced by endurance exercise (Lewis et al, 2010) were found to be decreased by endurance exercise (Figs 1D and EV1A–D).”
From Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation (2020) · cites this paper as Lewis et al, 2010
The observed increased levels of xanthosine associated with BDCM and total brominated THM and total THM are consistent with results from two previous studies.
“In addition, we observed increased levels of xanthosine associated with BDCM and total brominated THM and total THM, which is consistent with results from two previous studies (Daskalaki et al., 2015, Lewis et al., 2010).”
From Effects of exposure to water disinfection by-products in a swimming pool: A metabolome-wide association study (2018) · cites this paper as Lewis et al., 2010
HIF-1 transcriptionally directs a switch in metabolism from oxidative phosphorylation to glycolysis, allowing rapid ATP production without oxygen.
“It transcriptionally directs a switch in metabolism from oxidative phosphorylation to glycolysis, which allows rapid ATP production without the need for oxygen15.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [15]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114 · see citing works
HMDB: the Human Metabolome Database
Wishart, D. S., Tzur, D., Knox, C., Eisner, R., Guo, A. C., Young, N., Cheng, D., Jewell, K., Arndt, D., Sawhney, S., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl923 · Cited by 3,219 · see citing works
Grundy, S. M., Benjamin, I. J., Burke, G. L., Chait, A., Eckel, R. H., Howard, B. V., Mitch, W., Smith, S. C., & Sowers, J. R. (1999) · Circulation · doi:10.1161/01.cir.100.10.1134 · Cited by 2,698 · see citing works
ACC/AHA 2002 Guideline Update for Exercise Testing: Summary Article
Gibbons, R. J., Balady, G. J., Bricker, J. T., CHAITMAN, B. R., Fletcher, G. F., Froelicher, V. F., Mark, D. B., McCallister, B. D., Mooss, A. N., O’Reilly, M. G., et al. (2002) · Circulation · doi:10.1161/01.cir.0000034670.06526.15 · Cited by 2,606 · see citing works
Principles of Exercise Testing and Interpretation.
(1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-106-4-646 · Cited by 2,366 · see citing works
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
Sreekumar, A., Poisson, L., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., Laxman, B., Mehra, R., Lonigro, R. J., Li, Y., et al. (2009) · Nature · doi:10.1038/nature07762 · Cited by 2,238 · see citing works
Thompson, P. D., Buchner, D., Piña, I. L., Balady, G. J., Williams, M. A., Marcus, B. H., Berra, K., Blair, S. N., Costa, F., Franklin, B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000075572.40158.77 · Cited by 2,132 · see citing works
Bruce, R. A., Kusumi, F., & Hosmer, D. W. (1973) · American Heart Journal · doi:10.1016/0002-8703(73)90502-4 · Cited by 2,057 · see citing works
Fletcher, G. F., Balady, G. J., Amsterdam, E. A., Chaitman, B., Eckel, R., Fleg, J., Froelicher, V. F., Leon, A. S., Piña, I. L., Rodney, R., et al. (2001) · Circulation · doi:10.1161/hc3901.095960 · Cited by 1,923 · see citing works
Heart rate and cardiovascular mortality: The Framingham study
Kannel, W. B., Kannel, C., Paffenbarger, R. S., & Cupples, L. A. (1987) · American Heart Journal · doi:10.1016/0002-8703(87)90666-1 · Cited by 1,292 · see citing works
Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism
Nicholson, J. K., & Wilson, I. D. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1157 · Cited by 1,121 · see citing works
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
Raamsdonk, L. M., Teusink, B., Broadhurst, D., Zhang, N., Hayes, A., Walsh, M. C., BERDEN, J. A., Brindle, K. M., Kell, D. B., Rowland, J. J., et al. (2001) · Nature Biotechnology · doi:10.1038/83496 · Cited by 1,005 · see citing works
Predicted Values for Clinical Exercise Testing
Hansen, J. E., Sue, D. Y., & Wasserman, K. (1984) · American Review of Respiratory Disease · doi:10.1164/arrd.1984.129.2p2.s49 · Cited by 932 · see citing works
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
He, W., Miao, F. J.-P., Lin, D. C.-H., Schwandner, R. T., Wang, Z., Gao, J., Chen, J.-L., Tian, H., & Ling, L. (2004) · Nature · doi:10.1038/nature02488 · Cited by 909 · cited 1× · see citing works
“In addition to serving as potential biomarker signatures of disease states (20), circulating metabolites may themselves have unanticipated roles as regulatory signals with hormone-like functions (21, 22).”
Exercise Treadmill Score for Predicting Prognosis in Coronary Artery Disease
Mark, D. B., Hlatky, M. A., HARRELL, F. E., LEE, K. L., Califf, R. M., & PRYOR, D. B. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-106-6-793 · Cited by 666 · see citing works
Doehner, W., Schoene, N., Rauchhaus, M., Leyva‐Leon, F., Pavitt, D. V., Reaveley, D. A., Schuler, G. C., Coats, A. J. S., Anker, S. D., & Hambrecht, R. (2002) · Circulation · doi:10.1161/01.cir.0000017502.58595.ed · Cited by 565 · see citing works
High-throughput classification of yeast mutants for functional genomics using metabolic footprinting
Allen, J., Davey, H. M., Broadhurst, D., Heald, J. K., Rowland, J. J., Oliver, S. G., & Kell, D. B. (2003) · Nature Biotechnology · doi:10.1038/nbt823 · Cited by 538 · see citing works
The role of the exercise test in the evaluation of patients for ischemic heart disease.
McNeer, J. F., Margolis, J. R., Lee, K. L., KISSLO, J. A., Peter, R. H., Kong, Y., Behar, V. S., Wallace, A. G., McCants, C. B., & Rosati, R. A. (1978) · Circulation · doi:10.1161/01.cir.57.1.64 · Cited by 497 · see citing works
Rules of evidence for cancer molecular-marker discovery and validation
Ransohoff, D. F. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1322 · Cited by 493 · see citing works
Metabolomic Identification of Novel Biomarkers of Myocardial Ischemia
Sabatine, M. S., Liu, E. H., Morrow, D. A., Heller, E., McCarroll, R. M., Wiegand, R. C., Berriz, G. F., Roth, F. P., & Gerszten, R. E. (2005) · Circulation · doi:10.1161/circulationaha.105.569137 · Cited by 461 · see citing works
Self-citationAn, J., Muoio, D. M., Shiota, M., Fujimoto, Y., Cline, G. W., Shulman, G. I., Koves, T. R., Stevens, R., Millington, D., & Newgard, C. B. (2004) · Nature Medicine · doi:10.1038/nm995 · Cited by 450 · see citing works
The Production and Release of Glycerol by Adipose Tissue Incubated in Vitro
Vaughan, M. M. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70821-7 · Cited by 428 · see citing works
Shaham, O., Wei, R., Wang, T. J., Ricciardi, C., Lewis, G. D., Vasan, R. S., Carr, S. A., Thadhani, R., Gerszten, R. E., & Mootha, V. K. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.50 · Cited by 399 · see citing works
Self-citationEnergy metabolism of the heart: From basic concepts to clinical applications applications
Taegtmeyer, H. (1994) · Current Problems in Cardiology · doi:10.1016/0146-2806(94)90008-6 · Cited by 391 · see citing works
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
Sapieha, P., Sirinyan, M., Hamel, D., Zaniolo, K., Joyal, J.-S., Cho, J.-H., Honoré, J.-C., Kermorvant-Duchemin, E., Varma, D. R., Tremblay, S., et al. (2008) · Nature Medicine · doi:10.1038/nm.1873 · Cited by 359 · see citing works
Sildenafil Improves Exercise Hemodynamics and Oxygen Uptake in Patients With Systolic Heart Failure
Lewis, G. D., Lachmann, J. S., Camuso, J. M., Lepore, J. J., Shin, J. T., Martinovic, M. E., Systrom, D. M., Bloch, K. D., & Semigran, M. J. (2006) · Circulation · doi:10.1161/circulationaha.106.626226 · Cited by 352 · see citing works
Self-citationLewis, G. D., Wei, R., Liu, E. H., Yang, E., Shi, X., Martinovic, M. F., Farrell, L. A., Asnani, A. H., Cyrille, M., Ramanathan, A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35111 · Cited by 283 · see citing works
Self-citationTricarboxylic acid cycle intermediates in human muscle during prolonged exercise
Sahlin, K., Katz, A., & Broberg, S. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.259.5.c834 · Cited by 274 · see citing works
Fatty acid uptake and esterification in adipose tissue
Shapiro, B., Chowers, I., & Rose, G. (1957) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(57)90292-5 · Cited by 238 · see citing works
Grootveld, M. C., & Halliwell, B. B. (1987) · Biochemical Journal · doi:10.1042/bj2430803 · Cited by 236 · see citing works
Edward F. Adolph Distinguished Lecture: Muscle as an endocrine organ: IL-6 and other myokines
Pedersen, B. K. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00734.2009 · Cited by 214 · see citing works
Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity
Jocken, J. W. E., & Blaak, E. E. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.01.002 · Cited by 211 · see citing works
Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes
Cnop, M. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360348 · Cited by 207 · see citing works
Aragón, J. J., & Lowenstein, J. M. (1980) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1980.tb04877.x · Cited by 205 · see citing works
Snader, C. E. P., Marwick, T. H., Pashkow, F. J., Harvey, S. A., Thomas, J. D., & Lauer, M. S. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00217-9 · Cited by 205 · see citing works
Leg and arm lactate and substrate kinetics during exercise
van Hall, G., Jensen‐Urstad, M., Rosdahl, H. G., Holmberg, H., Saltin, B., & Calbet, J. A. L. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00273.2002 · Cited by 200 · see citing works
Nurjhan, N., Consoli, A., & Gerich, J. E. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115558 · Cited by 194 · see citing works
Nur77 Coordinately Regulates Expression of Genes Linked to Glucose Metabolism in Skeletal Muscle
Chao, L. C., Zhang, Z., Pei, L., Saito, T., Tontonoz, P., & Pilch, P. F. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0169 · Cited by 173 · see citing works
Gibala, M. J., MacLean, D. A., Graham, T. E., & Saltin, B. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.2.e235 · Cited by 160 · see citing works
Nur77 Regulates Lipolysis in Skeletal Muscle Cells
Maxwell, M., Cleasby, M. E., Harding, A. S., Stark, A., Cooney, G. J., & Muscat, G. E. O. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409580200 · Cited by 158 · see citing works
Effect of Exercise on Amino Acid Concentrations in Skeletal Muscle and Plasma
Henriksson, J. (1991) · Journal of Experimental Biology · doi:10.1242/jeb.160.1.149 · Cited by 141 · see citing works
Ammonia metabolism during exercise in man
Eriksson, L. S., Broberg, S., Björkman, O., & Wahren, J. (1985) · Clinical Physiology · doi:10.1111/j.1475-097x.1985.tb00753.x · Cited by 136 · see citing works
Laukkanen, J. A., Laaksonen, D. E., Lakka, T. A., Savonen, K. P., Rauramaa, R., Mäkikallio, T. H., & Kurl, S. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.01.371 · Cited by 127 · see citing works
Pohjanen, E., Thysell, E., Jonsson, P., Eklund, C., Silfver, A., Carlsson, I.-B., Lundgren, K., Möritz, T., Svensson, M., & Antti, H. (2007) · Journal of Proteome Research · doi:10.1021/pr070007g · Cited by 124 · see citing works
Chorell, E., Möritz, T., Branth, S., Antti, H., & Svensson, M. (2009) · Journal of Proteome Research · doi:10.1021/pr900081q · Cited by 109 · see citing works
Fat metabolism and acute resistance exercise in trained men
Ormsbee, M. J., Thyfault, J. P., Johnson, E. A., Kraus, R. M., Choi, M. D., & Hickner, R. C. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00704.2006 · Cited by 99 · see citing works
Cheng, C. P., Herfkens, R. J., & Taylor, C. A. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00641.2002 · Cited by 94 · see citing works
Tam, L., Li, E. K., Leung, V. Y. F., Griffith, J. F., Benzie, I. F. F., Lim, P. L., Whitney, B. M., Lee, V. W. Y., Lee, K. K. C., Thomas, G. N., et al. (2005) · PubMed · Cited by 83 · see citing works
Anaplerotic processes in human skeletal muscle during brief dynamic exercise
Gibala, M. J., MacLean, D. A., Graham, T. E., & Saltin, B. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.703bj.x · Cited by 83 · see citing works
A Longitudinal Study of Physical Activity and Heart Rate Recovery: CARDIA, 1987???1993
Carnethon, M. R., Jacobs, D. R., Sidney, S. S., Sternfeld, B., Gidding, S. S., Shoushtari, C. S., & Liu, K. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000158190.56061.32 · Cited by 74 · see citing works
Crinò, A., Schiaffini, R., Manfrini, S., Mesturino, C. A., Visalli, N., Anguissola, G. B., SURACI, C., Pitocco, D., Spera, S., Corbi, S., et al. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500719 · Cited by 70 · see citing works
Sahlin, K., Górski, J., & Edström, L. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.259.3.c409 · Cited by 68 · see citing works
Nicotinamide — biological actions and therapeutic potential in diabetes prevention
Pociot, F., Reimers, J. I., & Andersen, H. U. (1993) · Diabetologia · doi:10.1007/bf02743277 · Cited by 60 · see citing works
Lessard, S. J., Rivas, D. A., Chen, Z., van Denderen, B. J., Watt, M. J., Koch, L. G., Britton, S. L., Kemp, B. E., & Hawley, J. A. (2009) · Endocrinology · doi:10.1210/en.2009-0158 · Cited by 56 · see citing works
Nurjhan, N., Kennedy, F. P., Consoli, A., Martin, C., Miles, J., & Gerich, J. E. (1988) · Metabolism · doi:10.1016/0026-0495(88)90140-0 · Cited by 55 · see citing works
Effects of Resistance Exercise on Lipolysis during Subsequent Submaximal Exercise
Goto, K., Ishii, N., Sugihara, S., Yoshioka, T., & Takamatsu, K. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000246992.33482.cb · Cited by 55 · see citing works
Nauman, J., Nilsen, T. I. L., Wisløff, U., & Vatten, L. J. (2010) · Journal of Epidemiology and Community Health · doi:10.1136/jech.2009.093088 · Cited by 41 · see citing works
Orphan nuclear receptors: therapeutic opportunities in skeletal muscle
Smith, A. G., & Muscat, G. E. O. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00476.2005 · Cited by 37 · see citing works
The Determination of Allantoin, a Possible Indicator of Oxidant Status, in Human Plasma
Lagendijk, J., Ubbink, J., & Vermaak, W. J. H. (1995) · Journal of Chromatographic Science · doi:10.1093/chromsci/33.4.186 · Cited by 36 · see citing works
Is systolic blood pressure recovery after exercise a predictor of mortality?
Ellis, K., Pothier, C. E., Blackstone, E. H., & Lauer, M. S. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.08.009 · Cited by 30 · see citing works
The disposition of citric acid cycle intermediates by isolated rat heart mitochondria
Hiltunen, J. K., & DAVIS, E. (1981) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(81)90054-4 · Cited by 29 · see citing works
THE METABOLISM IN VITRO OF CARDIAC MUSCLE IN PANTOTHENIC ACID DEFICIENCY
Olson, R. E., & Stare, F. J. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)56055-5 · Cited by 23 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [44]Tam LS Li EK Leung VY Griffith JF Benzie IF Lim PL Whitney B Lee VW Lee KK Thomas GN Tomlinson B J Rheumatol 2005 32 275 15693087
- [63]Benjamini Y Hochberg Y Journal of the Royal Statistical Society, Series B 1995 57 289
Cited by
Sorted by citations
Metabolomics for Investigating Physiological and Pathophysiological Processes
Wishart, D. S. (2019) · Physiological Reviews · doi:10.1152/physrev.00035.2018 · Cited by 1,246 · see citing works
Metabolic Control of Longevity
López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753 · see citing works
Physical activity and muscle-brain crosstalk
Pedersen, B. K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0174-x · Cited by 772 · see citing works
Agudelo, L. Z., Femenía, T., Orhan, F., Porsmyr-Palmertz, M., Goiny, M., Martinez-Redondo, V., Correia, J. C., Izadi, M., Bhat, M., Schuppe-Koistinen, I., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.051 · Cited by 739 · see citing works
Roberts, L. D., Souza, A. L., Gerszten, R. E., & Clish, C. B. (2012) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb3002s98 · Cited by 714 · see citing works
Self-citationMolecular Choreography of Acute Exercise
Contrepois, K., Wu, S., Moneghetti, K. J., Hornburg, D., Ahadi, S., Tsai, M.-S., Metwally, A. A., Wei, E., Lee-McMullen, B., Quijada, J. V., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.043 · Cited by 502 · see citing works
The potential of endurance exercise-derived exosomes to treat metabolic diseases
Safdar, A., Saleem, A., & Tarnopolsky, M. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.76 · Cited by 463 · see citing works
Cardiopulmonary Exercise Testing in Heart Failure
Malhotra, R. K., Bakken, K., D’Elia, E., & Lewis, G. D. (2016) · JACC Heart Failure · doi:10.1016/j.jchf.2016.03.022 · Cited by 456 · see citing works
Self-citationDunn, W. B., Wilson, I. D., Nicholls, A. W., & Broadhurst, D. (2012) · Bioanalysis · doi:10.4155/bio.12.204 · Cited by 442 · see citing works
The Mitochondrial Basis of Aging and Age-Related Disorders
Srivastava, S. (2017) · Genes · doi:10.3390/genes8120398 · Cited by 428 · see citing works
Coupling Krebs cycle metabolites to signalling in immunity and cancer
Ryan, D. G., Murphy, M. P., Frezza, C., Prag, H. A., Chouchani, E. T., O’Neill, L. A., & Mills, E. L. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0014-7 · Cited by 398 · see citing works
Shah, S. H., Kraus, W. E., & Newgard, C. B. (2012) · Circulation · doi:10.1161/circulationaha.111.060368 · Cited by 371 · see citing works
Force, T. L., & Kolaja, K. L. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3252 · Cited by 368 · see citing works
The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases
Nakahira, K., Hisata, S., & Choi, A. M. K. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6407 · Cited by 363 · see citing works
Wang, D. D., Toledo, E., Hruby, A., Rosner, B. A., Willett, W. C., Sun, Q., Razquin, C., Zheng, Y., Ruiz-Canela, M., Guasch-Ferré, M., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.024261 · Cited by 327 · see citing works
Self-citationAn exercise-inducible metabolite that suppresses feeding and obesity
Li, V. L., He, Y., Contrepois, K., Liu, H., Kim, J. T., Wiggenhorn, A. L., Tanzo, J. T., Tung, A. S.-H., Lyu, X., Zushin, P.-J. H., et al. (2022) · Nature · doi:10.1038/s41586-022-04828-5 · Cited by 331 · see citing works
The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite
Huergo, L. F., & Dixon, R. A. (2015) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00038-15 · Cited by 314 · see citing works
Sanford, J. A., Nogiec, C. D., Lindholm, M. E., Adkins, J., Amar, D., Dasari, S., Drugan, J. K., Fernández, F. M., Radom‐Aizik, S., Schenk, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.004 · Cited by 300 · see citing works
Metabolic Signatures of Insulin Resistance in 7,098 Young Adults
Würtz, P., Mäkinen, V., Soininen, P., Kangas, A. J., Tukiainen, T., Kettunen, J., Savolainen, M. J., Tammelin, T., Viikari, J. S. A., Rönnemaa, T., et al. (2012) · Diabetes · doi:10.2337/db11-1355 · Cited by 304 · see citing works
Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation
Agudelo, L. Z., Ferreira, D. M. S., Červenka, I., Bryzgalova, G., Dadvar, S., Jannig, P. R., Pettersson-Klein, A. T., Lakshmikanth, T., Sustarsic, E. G., Porsmyr‐Palmertz, M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.004 · Cited by 303 · see citing works
Blood-brain barrier permeability and physical exercise
Małkiewicz, M. A., Szarmach, A., Sabisz, A., Cubała, W. J., Szurowska, E., & Winklewski, P. J. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1403-x · Cited by 276 · see citing works
Endocrine Crosstalk Between Skeletal Muscle and the Brain
Delezie, J., & Handschin, C. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00698 · Cited by 270 · see citing works
A diabetes-predictive amino acid score and future cardiovascular disease
Magnusson, M., Lewis, G. D., Ericson, U., Orho‐Melander, M., Hedblad, B., Engström, G., Östling, G., Clish, C. B., Wang, T. J., Gerszten, R. E., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs424 · Cited by 264 · see citing works
Self-citationAddona, T. A., Shi, X. D., Keshishian, H., Mani, D. R., Burgess, M. W., Gillette, M. A., Clauser, K. R., Shen, D., Lewis, G. D., Farrell, L. A., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1899 · Cited by 249 · see citing works
Self-citationSchranner, D., Kastenmüller, G., Schönfelder, M., Römisch‐Margl, W., & Wackerhage, H. (2020) · Sports Medicine - Open · doi:10.1186/s40798-020-0238-4 · Cited by 250 · see citing works
Metabolomics and Cardiovascular Biomarker Discovery
Rhee, E. P., & Gerszten, R. E. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2011.169573 · Cited by 232 · see citing works
Self-citationRhodes, C. J., Ghataorhe, P., Wharton, J., Rue-Albrecht, K., Hadinnapola, C., Watson, G., Bleda, M., Haimel, M., Coghlan, G., Corris, P. A., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.024602 · Cited by 217 · see citing works
Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit
McGee, S. L., & Hargreaves, M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0377-1 · Cited by 221 · see citing works
Ngo, D., Sinha, S., Shen, D., Kuhn, E. W., Keyes, M. J., Shi, X. D., Benson, M. D., O’Sullivan, J., Keshishian, H., Farrell, L. A., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.021803 · Cited by 214 · see citing works
Self-citationAriza, A. C., Deen, P. M. T., & Robben, J. H. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00022 · Cited by 211 · see citing works
Peake, J. M., Tan, S. J., Markworth, J. F., Broadbent, J. A., Skinner, T. L., & Cameron‐Smith, D. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00276.2014 · Cited by 209 · see citing works
Cheng, S. C., Shah, S. H., Corwin, E. J., Fiehn, O., Fitzgerald, R. L., Gerszten, R. E., Illig, T., Rhee, E. P., Srinivas, P. R., Wang, T. J., et al. (2017) · Circulation Cardiovascular Genetics · doi:10.1161/hcg.0000000000000032 · Cited by 191 · see citing works
Self-citationPlasma Metabolome Profiling of Resistance Exercise and Endurance Exercise in Humans
Morville, T. H., Sahl, R. E., Möritz, T., Helge, J. W., & Clemmensen, C. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108554 · Cited by 179 · see citing works
Human metabolic profiles are stably controlled by genetic and environmental variation
Nicholson, G., Rantalainen, M., Maher, A. D., Li, J. V., Malmodin, D., Ahmadi, K. R., Faber, J. H., Hallgrímsdóttir, I. B., Barrett, A., Toft, H., et al. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.57 · Cited by 173 · see citing works
Metabolomics, physical activity, exercise and health: A review of the current evidence
Kelly, R. S., Kelly, M. P., & Kelly, P. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165936 · Cited by 175 · see citing works
Schlittler, M., Goiny, M., Agudelo, L. Z., Venckūnas, T., Brazaitis, M., Skurvydas, A., Kamandulis, S., Ruas, J. L., Erhardt, S., Westerblad, H., et al. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00053.2016 · Cited by 173 · see citing works
Gostner, J. M., Geisler, S., Stonig, M., Mair, L., Sperner‐Unterweger, B., & Fuchs, D. (2019) · Neuropsychobiology · doi:10.1159/000496293 · Cited by 167 · see citing works
CURRENT NUTRITIONAL RECOMMENDATIONS AND NOVEL DIETARY STRATEGIES TO MANAGE SARCOPENIA
Calvani, R., Miccheli, A., Landi, F., Bossola, M., Cesari, M., Leeuwenburgh, C., Sieber, C. C., Bernabei, R., & Marzetti, E. (2013) · The Journal of Frailty & Aging · doi:10.14283/jfa.2013.7 · Cited by 163 · see citing works
Bernardo, B. C., Ooi, J. Y. Y., Weeks, K. L., Patterson, N. L., & McMullen, J. R. (2017) · Physiological Reviews · doi:10.1152/physrev.00043.2016 · Cited by 168 · see citing works
Ang, J. E., Revell, V., Mann, A., Mäntele, S., Otway, D. T., Johnston, J. D., Thumser, A. E., Skene, D. J., & Raynaud, F. (2012) · Chronobiology International · doi:10.3109/07420528.2012.699122 · Cited by 138 · see citing works
Al‐Khelaifi, F., Diboun, I., Donati, F., Botrè, F., Alsayrafi, M., Georgakopoulos, C. G., Suhre, K., Yousri, N. A., & Elrayess, M. A. (2018) · Sports Medicine - Open · doi:10.1186/s40798-017-0114-z · Cited by 139 · see citing works
Mitochondrial metabolites: undercover signalling molecules
Frezza, C. (2017) · Interface Focus · doi:10.1098/rsfs.2016.0100 · Cited by 136 · see citing works
Metabolomics and Lipidomics: Expanding the Molecular Landscape of Exercise Biology
Belhaj, M. R., Lawler, N. G., & Hoffman, N. J. (2021) · Metabolites · doi:10.3390/metabo11030151 · Cited by 135 · see citing works
Metabolite Profiling Identifies a Branched Chain Amino Acid Signature in Acute Cardioembolic Stroke
Kimberly, W. T., Wang, Y., Pham, L., Furie, K. L., & Gerszten, R. E. (2013) · Stroke · doi:10.1161/strokeaha.111.000397 · Cited by 128 · see citing works
Self-citationPechlivanis, A., Kostidis, S., Saraslanidis, P., Petridou, A., Tsalis, G., Mougios, V., Gika, H. G., Mikros, E., & Theodoridis, G. A. (2010) · Journal of Proteome Research · doi:10.1021/pr100684t · Cited by 124 · see citing works
The Pathophysiological Role of CoA
Czumaj, A., Szrok-Jurga, S., Hebanowska, A., Turyn, J., Świerczyński, J., Śledziński, T., & Stelmańska, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239057 · Cited by 126 · see citing works
Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction
Cefis, M., Chaney, R., Wirtz, J., Méloux, A., Quirié, A., Leger, C., Prigent‐Tessier, A., & Garnier, P. E. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1275924 · Cited by 130 · see citing works
Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations
Leoni, V., Strittmatter, L., Zorzi, G. S., Zibordi, F., Dusi, S., Garavaglia, B., Venco, P., Caccia, C., Souza, A. L., Deik, A., et al. (2011) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2011.12.005 · Cited by 124 · see citing works
Self-citationLewis, G. D., Ngo, D., Hemnes, A. R., Farrell, L. A., Domos, C., Pappagianopoulos, P. P., Dhakal, B. P., Souza, A., Shi, X. D., Pugh, M. E., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.10.072 · Cited by 123 · see citing works
Self-citationSakaguchi, C. A., Nieman, D. C., Signini, É. D. F., de Abreu, R. M., & Catai, A. M. (2019) · Metabolites · doi:10.3390/metabo9080164 · Cited by 116 · see citing works
Muscle-to-Brain Signaling Via Myokines and Myometabolites
Rai, M., & Demontis, F. (2022) · Brain Plasticity · doi:10.3233/bpl-210133 · Cited by 121 · see citing works
Metabolic Architecture of Acute Exercise Response in Middle-Aged Adults in the Community
Nayor, M. G., Shah, R. V., Miller, P. E., Blodgett, J. B., Tanguay, M., Pico, A. R., Murthy, V. L., Malhotra, R. K., Houstis, N. E., Deik, A., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.050281 · Cited by 110 · see citing works
Self-citationBody Fat Free Mass Is Associated with the Serum Metabolite Profile in a Population-Based Study
Jourdan, C., Petersen, A.-K., Gieger, C., Döring, A., Illig, T., Wang‐Sattler, R., Meisinger, C., Peters, A., Adamski, J., Prehn, C. P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040009 · Cited by 107 · see citing works
Relationship Between Sweat and Blood Lactate Levels During Exhaustive Physical Exercise
Karpova, E. V., Laptev, A. I., Andreev, E. A., Karyakina, E. E., & Karyakin, A. A. (2020) · ChemElectroChem · doi:10.1002/celc.201901703 · Cited by 107 · see citing works
Can Exercise Teach Us How to Treat Heart Disease?
Mann, N., & Rosenzweig, A. (2012) · Circulation · doi:10.1161/circulationaha.111.060376 · Cited by 105 · see citing works
Rowe, G. C., Safdar, A., & Arany, Z. P. (2014) · Circulation · doi:10.1161/circulationaha.113.001590 · Cited by 104 · see citing works
Self-citationNieman, D., & Mitmesser, S. (2017) · Nutrients · doi:10.3390/nu9050513 · Cited by 103 · see citing works
Why should people with type 1 diabetes exercise regularly?
Codella, R., Terruzzi, I. M., & Luzi, L. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-0978-x · Cited by 103 · see citing works
A Network Perspective on Metabolism and Aging
Soltow, Q. A., Jones, D. P., & Promislow, D. (2010) · Integrative and Comparative Biology · doi:10.1093/icb/icq094 · Cited by 102 · see citing works
Tabone, M., Bressa, C., García-Merino, J. A., Moreno‐Pérez, D., Chu‐Van, E., Castelli, F. A., Fenaille, F., & Larrosa, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-82947-1 · Cited by 100 · see citing works
Organism-wide, cell-type-specific secretome mapping of exercise training in mice
Wei, W., Riley, N. M., Lyu, X., Shen, X., Guo, J., Raun, S. H., Zhao, M., Moya-Garzón, M. D., Basu, H., Tung, A. S.-H., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.04.011 · Cited by 97 · see citing works
Kynurenine Pathway in Diabetes Mellitus—Novel Pharmacological Target?
Kozieł, K., & Urbańska, E. M. (2023) · Cells · doi:10.3390/cells12030460 · Cited by 101 · see citing works
Sample Preparation Prior to The LC–MS-Based Metabolomics/Metabonomics of Blood-Derived Samples
Gika, H., & Theodoridis, G. A. (2011) · Bioanalysis · doi:10.4155/bio.11.122 · Cited by 97 · see citing works
Every exercise bout matters: linking systemic exercise responses to breast cancer control
Dethlefsen, C., Pedersen, K. S., & Højman, P. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4129-4 · Cited by 94 · see citing works
A Rat Model System to Study Complex Disease Risks, Fitness, Aging, and Longevity
Koch, L. G., Britton, S. L., & Wisløff, U. (2012) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2012.06.007 · Cited by 94 · see citing works
Yuan, Y., Xu, P., Jiang, Q., Cai, X., Wang, T., Peng, W., Sun, J., Zhu, C., Zhang, C., Yue, D., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019103304 · Cited by 92 · see citing works
“For the endurance exercise group, mice were forced running on a treadmill (47300 TREADMILL; Ugo Basile, Italy) as described previously (Lewis et al , 2010).”
Self-citationNieman, D. C., Shanely, R. A., Gillitt, N. D., Pappan, K. L., & Lila, M. A. (2013) · Journal of Proteome Research · doi:10.1021/pr400717j · Cited by 92 · see citing works
van Veldhoven, K., Keski-Rahkonen, P., Barupal, D. K., Villanueva, C. M., Font-Ribera, L., Scalbert, A., Bodinier, B., Grimalt, J. O., Zwiener, C., Vlaanderen, J., et al. (2018) · Environment International · doi:10.1016/j.envint.2017.11.017 · Cited by 94 · see citing works
Hansen, J. S., Zhao, X., Irmler, M., Liu, X., Hoene, M., Scheler, M., Li, Y., Beckers, J., de Angelis, M. H., Häring, H., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3584-x · Cited by 90 · see citing works
The maternal-age-associated risk of congenital heart disease is modifiable
Schulkey, C. E., Regmi, S. D., Magnan, R. A., Danzo, M. T., Luther, H., Hutchinson, A. K., Panzer, A. A., Grady, M. M., Wilson, D. B., & Jay, P. Y. (2015) · Nature · doi:10.1038/nature14361 · Cited by 90 · see citing works
Toward New Biomarkers of Cardiometabolic Diseases
Roberts, L. D., & Gerszten, R. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.009 · Cited by 89 · see citing works
Self-citationMidha, A. D., Zhou, Y., Queliconi, B. B., Barrios, A. M., Haribowo, A. G., Chew, B. T. L., Fong, C. O. Y., Blecha, J. E., VanBrocklin, H. F., Seo, Y., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.02.007 · Cited by 88 · see citing works
Lohavanichbutr, P., Zhang, Y., Wang, P., Gu, H., Gowda, G. A. N., Djukovic, D., Buas, M. F., Raftery, D., & Chen, C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204249 · Cited by 88 · see citing works
Human plasma proteomic profiles indicative of cardiorespiratory fitness
Robbins, J., Peterson, B. D., Schranner, D., Tahir, U. A., Rienmüller, T. M., Deng, S., Keyes, M. J., Katz, D. H., Beltran, P. M. J., Barber, J. L., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00400-z · Cited by 83 · see citing works
Self-citationPechlivanis, A., Kostidis, S., Saraslanidis, P., Petridou, A., Tsalis, G. A., Veselkov, K., Mikros, E., Mougios, V., & Theodoridis, G. A. (2012) · Journal of Proteome Research · doi:10.1021/pr300846x · Cited by 87 · see citing works
Molecular insights of exercise therapy in disease prevention and treatment
Walzik, D., Chirino, T. Y. W., Zimmer, P., & Joisten, N. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01841-0 · Cited by 89 · see citing works
A metabolic signature predicts biological age in mice
Tomás‐Loba, A., de Jesus, B. B., Mato, J. M., & Blasco, M. A. (2012) · Aging Cell · doi:10.1111/acel.12025 · Cited by 83 · see citing works
The Interplay Between Exercise Metabolism, Epigenetics, and Skeletal Muscle Remodeling
Seaborne, R. A. E., & Sharples, A. P. (2020) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000227 · Cited by 81 · see citing works
Systems biology strategies to study lipidomes in health and disease
Hyötyläinen, T., & Orešič, M. (2014) · Progress in Lipid Research · doi:10.1016/j.plipres.2014.06.001 · Cited by 82 · see citing works
Nieman, D. C., Lila, M. A., & Gillitt, N. D. (2019) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-032818-121316 · Cited by 85 · see citing works
Brugnara, L., Vinaixa, M., Murillo, S., Samino, S., Rodriguez, M. A., Beltran, A., Lerín, C., Davison, G. W., Correig, X., & Novials, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040600 · Cited by 81 · see citing works
Lewis, K. N., Rubinstein, N. D., & Buffenstein, R. (2018) · GeroScience · doi:10.1007/s11357-018-0014-2 · Cited by 78 · see citing works
Alpha-ketoglutarate as a potent regulator for lifespan and healthspan: Evidences and perspectives
Naeini, S. H., Mavaddatiyan, L., Kalkhoran, Z. R., Taherkhani, S., & Talkhabi, M. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112154 · Cited by 83 · see citing works
Tham, Y. K., Bernardo, B. C., Huynh, K., Ooi, J. Y. Y., Gao, X. M., Kiriazis, H., Giles, C., Meikle, P. J., & McMullen, J. R. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.08.017 · Cited by 76 · see citing works
Bananas as an Energy Source during Exercise: A Metabolomics Approach
Nieman, D. C., Gillitt, N. D., Henson, D. A., Sha, W., Shanely, R. A., Knab, A. M., Cialdella-Kam, L. A., & Jin, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037479 · Cited by 74 · see citing works
Biochemical and High Throughput Microscopic Assessment of Fat Mass in Caenorhabditis Elegans
Pino, E. C., Webster, C. M., Carr, C. E., & Soukas, A. A. (2013) · Journal of Visualized Experiments · doi:10.3791/50180 · Cited by 74 · see citing works
Pribil, M. M., Laptev, G. U., Karyakina, E. E., & Karyakin, A. A. (2014) · Analytical Chemistry · doi:10.1021/ac501547u · Cited by 74 · see citing works
Grape polyphenols supplementation for exercise-induced oxidative stress
Elejalde, E., Villarán, M. C., & Alonso, R. M. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00395-0 · Cited by 72 · see citing works
Shen, J., Yan, L., Liu, S., Ambrosone, C. B., & Zhao, H. (2013) · Translational Oncology · doi:10.1593/tlo.13619 · Cited by 72 · see citing works
Translating Metabolomics to Cardiovascular Biomarkers
Senn, T. N., Hazen, S. L., & Tang, W. H. W. (2012) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2012.06.004 · Cited by 71 · see citing works
Karl, J. P., Margolis, L. M., Murphy, N. E., Carrigan, C. T., Castellani, J. W., Madslien, E. H., Teien, H. K., Martini, S., Montain, S. J., & Pasiakos, S. M. (2017) · Physiological Reports · doi:10.14814/phy2.13407 · Cited by 68 · see citing works
Metabolic response to green tea extract during rest and moderate-intensity exercise
Hodgson, A. B., Randell, R. K., Boon, N., Garczarek, U., Mela, D. J., Jeukendrup, A. E., & Jacobs, D. M. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.06.017 · Cited by 69 · see citing works
Mukherjee, K., Edgett, B. A., Burrows, H. W., Castro, C., Griffin, J. L., Schwertani, A. G., Gurd, B. J., & Funk, C. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092031 · Cited by 65 · see citing works
Effect of chronic exercise in healthy young male adults: a metabolomic analysis
Koay, Y. C., Stanton, K., Kienzle, V., Li, M., Yang, J. Y. H., Celermajer, D. S., & O’Sullivan, J. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa051 · Cited by 66 · see citing works
Metabolic and endocrine response to exercise: sympathoadrenal integration with skeletal muscle
Ball, D. R. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0408 · Cited by 66 · see citing works
Metabolic time-course response after resistance exercise: A metabolomics approach
Berton, R., Conceição, M. S., Libardi, C. A., Canevarolo, R. R., Gáspari, A. F., Chacon-Mikahil, M. P. T., Zeri, A. C., & Cavaglieri, C. R. (2017) · Journal of Sports Sciences · doi:10.1080/02640414.2016.1218035 · Cited by 65 · see citing works
l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism
Adachi, Y., Sousa‐Coelho, A. L. D., Harata, I., Aoun, C., Weimer, S., Shi, X. D., Herrera, K. N. G., Takahashi, H., Doherty, C., Noguchi, Y., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.08.002 · Cited by 63 · see citing works
Self-citationAssay of the Multiple Energy-Producing Pathways of Mammalian Cells
Bochner, B. R., Siri, M., Huang, R. H., Noble, S., Lei, X.-H., Clemons, P. A., & Wagner, B. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018147 · Cited by 62 · see citing works
Papandreou, C., Bulló, M., Zheng, Y., Ruiz‐Canela, M., Yu, E., Guasch‐Ferré, M., Toledo, E., Clish, C. B., Corella, D., Estruch, R., et al. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy058 · Cited by 63 · see citing works
Self-citationPhysical fitness level is reflected by alterations in the human plasma metabolome
Chorell, E., Svensson, M., Möritz, T., & Antti, H. (2012) · Molecular BioSystems · doi:10.1039/c2mb05428k · Cited by 61 · see citing works
- Authors
- Lewis, G. D., Farrell, L., Wood, M. J., Martinovic, M., Arany, Z., Rowe, G. C., Souza, A., Cheng, S., McCabe, E. L., Yang, E., Shi, X., Deo, R., Roth, F. P., Asnani, A., Rhee, E. P., Systrom, D. M., Semigran, M. J., Vasan, R. S., Carr, S. A., Wang, T. J., Sabatine, M. S., Clish, C. B., & Gerszten, R. E.
- Affiliations
- Broad Institute (US)
- Massachusetts General Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Brigham and Women's Hospital (US)
- Framingham Heart Study (US)
- Harvard University (US)
- Boston University (US)
- Corresponding author
- Lewis, Gregory D.
- Gerszten, Robert E.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2010-05-26
- Volume
- 2
- Issue
- 33
- Pages
- 33ra37-33ra37
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3010398
- OpenAlex
- W2171282332
- Cited by
- 432
- References
- 63
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 22 · 2023: 26 · 2022: 28 · 2021: 31 · 2020: 51 · 2019: 34 · 2018: 24 · 2017: 30 · 2016: 19 · 2015: 26 · 2014: 18 · 2013: 26 · 2012: 28
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (R01HL072872, N01‐HC25195, U01HL083141, N01-HC-025195, R01HL083141, K23HL091106)
- National Human Genome Research Institute (HG004233, HG0017115, R01HG003224, HG003224, P50HG004233)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK081572)
- National Institute of Neurological Disorders and Stroke (R01NS054052, NS054052)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- physical activity, plasma metabolites, metabolic signatures, glycogenolysis, glucose-6-phosphate, TCA cycle, succinic acid, malate, fumarate, lipolysis, glycerol, insulin sensitivity, nicotinamide, pantothenic acid, fatty acid oxidation, exercise fitness, myocardial ischemia, Nur77, lipid metabolism, cardiovascular disease susceptibility, marathon running
- MeSH terms
- Adult, Aged, Animals, Blood, Cell Line, Energy Metabolism, Humans, Male, Middle Aged, Psychomotor Performance, Exercise, Muscle, Skeletal, Mice, Metabolomics, Nuclear Receptor Subfamily 4, Group A, Member 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
