Potent anti‐microbial activity of traditional Chinese medicine herbs against Candida species
Abstract
Summary: Anti‐candidial activities of eight traditional Chinese medicinal (TCM) herbs were evaluated against six different Candida species. TCM preparations were screened for antifungal activity using a standard agar diffusion assay. Following identification of potential candidate herbs, their minimum inhibitory concentration (MIC) values were determined using the standardised NCCLS M‐27A broth microdilution assay. Among TCM herbs, Rhizoma Coptidis had potent antifungal activity against Candida glabrata, Candida krusei and Candida tropicalis, but not against Candida albicans, Candida dubliniensis and Candida parapsolosis. The MIC values of the Rhizoma Coptidis against C. glabrata, C. krusei and C. tropicalis were 50, 50 and 100 μg ml−1 respectively. We report here, for the first time, the potent antifungal activity of Rhizoma Coptidis and Cortex phellodendri Chinesis on three different non‐albicans Candida species, C. glabrata, C. krusei and C. tropicalis and hence their possible use as therapeutic agents.
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Infections caused by non-albicans Candida species are progressively increasing and are usually resistant to common antifungals, emphasizing the need for novel therapies.
“In the case of C. utilis, infections caused by nonalbicans Candida species are progressively increasing and usually the cases are resistant to common antifungals, which emphasizes the need for novel therapies for their effective management.35”
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- Authors
- Seneviratne, C. J., Wong, R. W. K., & Samaranayake, L. P.
- Affiliations
- Prince Philip Dental Hospital (CN)
- Corresponding author
- Samaranayake, Lakshman P.
- Venue
- Mycoses
- Publisher
- Wiley
- Published
- 2007-10-09
- Volume
- 51
- Issue
- 1
- Pages
- 30-34
- ISSN
- 0027-5557 (ISSN-L)
- 0933-7407
- 1439-0507
- OpenAlex
- W2080013182
- Cited by
- 51
- References
- 15
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 5 · 2012: 6
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mycoses (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- Chinese herbal medicine, antifungal activity, Candida, Coptidis Rhizoma, Candida glabrata, Candida krusei, Candida tropicalis, non-albicans Candida, minimum inhibitory concentration, herbal antifungal agents
- MeSH terms
- Antifungal Agents, Candida, Drugs, Chinese Herbal, Microbial Sensitivity Tests
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