Epidemiology of Candida albicans Infections and Role of Non-Candidaalbicans Yeasts

Ruhnke, Markus

doi:10.2174/138945006776359421

Cited by 210Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal Infections and Studies

Epidemiology of Candida albicans Infections and Role of Non-Candidaalbicans Yeasts

Ruhnke, Markus·2006·Current Drug Targets

DOI 10.2174/138945006776359421

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Abstract

Infections of the skin and the mucous membranes due to Candida species may occur either in immuncompromised or in non-immuncompromised patients. This is in contrast to systemic candidiasis (e.g. candidemia) which is only seen in severely immunocompromised patients. Bloodstream infections caused by Candida species are increasingly recognized in critical ill adult and pediatric individuals, with significant associated morbidity and mortality. Candida albicans is the single most common fungal species causing nosocomial infections. However, non-Candida albicans spp., including fluconazole-less-susceptible Candida glabrata, have become more common pathogens. In some patient populations such as hematological (neutropenic) patients Non-C. albicans species are detected much more frequently as compared to non-neutropenic patients in the intensive care. Non-C. albicans species are more likely to occur in patients, who receive or have received antifungal therapy with azoles (e.g. fluconazole). In this review the current epidemiological trends in mucosal and invasive candidiasis are discussed with regard to the role of non-Candida albicans species as the causative agent in immunocompromised patients.

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Historically, Candida albicans has been the leading cause of candidemia; however, candidemia involving non-C. albicans spp., especially Candida glabrata, Candida parapsilosis, Candida tropicalis, and Candida krusei, has become more prevalent in recent years.
“Historically, Candida albicans has been the leading cause of candidemia; however, candidemia involving non-C. albicans spp., especially Candida glabrata, Candida parapsilosis, Candida tropicalis, and Candida krusei, has become more prevalent in recent years (11).”
From Population-Based Active Surveillance for Culture-Confirmed Candidemia — 10 Sites, United States, 2017–2021 (2025) · cites this paper as [11]

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Authors: Ruhnke, M.
Affiliations: Humboldt-Universität zu Berlin (DE)
Corresponding author: Ruhnke, Markus
ORCID: Ruhnke, Markus
Venue: Current Drug Targets
Publisher: Bentham Science Publishers Ltd.
Published: 2006-04-01
Volume: 7
Issue: 4
Pages: 495-504
ISSN: 1389-4501 (ISSN-L)
DOI: 10.2174/138945006776359421
OpenAlex: W2091312819
Cited by: 210
References: 0
Citations by year: 2026: 4 · 2025: 10 · 2024: 6 · 2023: 11 · 2022: 4 · 2021: 8 · 2020: 3 · 2019: 12 · 2018: 6 · 2017: 7 · 2016: 6 · 2015: 8 · 2014: 13 · 2013: 15 · 2012: 10
FWCI: 10.87
Type: journal article
Language: en
Open access: closed
Locations: Current Drug Targets (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords: Candida albicans, Candida glabrata, invasive candidiasis, candidemia, mucosal candidiasis, immunocompromised patients, nosocomial infections, fluconazole resistance, azole antifungal therapy, hematologic patients, neutropenia, intensive care unit patients, fungal epidemiology
MeSH terms: Candida, Candida albicans, Candidiasis, Europe, Humans, Prognosis, Risk Factors, Drug Resistance, Fungal

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Epidemiology of Candida albicans Infections and Role of Non-Candidaalbicans Yeasts

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