Influence of alcohol and caffeine consumption on caffeine elimination
Abstract
Ten healthy male volunteers were each studied on four separate occasions to assess the role of regular caffeine and alcohol intake on caffeine elimination. Antipyrine disappearance was also studied as an established quantitative test of hepatic microsomal function. Regular caffeine intake in high doses for 1 week failed to alter either antipyrine or caffeine pharmacokinetics. In contrast, alcohol intake of 50 g/day significantly prolonged caffeine half-life by 72% (P less than 0.005) and diminished caffeine clearance by 36% (P less than 0.0005). However, antipyrine kinetics were unaltered. These results demonstrate that alcohol, in amounts commonly consumed, is a strong inhibitor of caffeine metabolism.
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Substantial alcohol intake increases the half-life of caffeine and decreases its clearance.
“Substantial alcohol intake increases the half-life of caffeine and decreases its clearance (65).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [65]
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- Authors
- George, J., Murphy, T., Roberts, R., Cooksley, W. G. E., Halliday, J. W., & Powell, L. W.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Powell, L. W.
- Venue
- Clinical and Experimental Pharmacology and Physiology
- Publisher
- Wiley
- Published
- 1986-10
- Volume
- 13
- Issue
- 10
- Pages
- 731-736
- ISSN
- 0305-1870 (ISSN-L)
- 1440-1681
- OpenAlex
- W2150318679
- Cited by
- 53
- References
- 23
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 4
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical and Experimental Pharmacology and Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- caffeine, alcohol, caffeine half-life, caffeine clearance, antipyrine, drug-drug interactions, pharmacokinetics
- MeSH terms
- Adult, Alcohol Drinking, Antipyrine, Caffeine, Coffee, Half-Life, Humans, Kinetics, Male
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