ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR FUNCTION

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POLYAMINES

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Nitrogen metabolism and ornithine cycle function

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Overexpression of (His) 6 -tagged human arginase I in Saccharomyces cerevisiae and enzyme purification using metal affinity chromatography

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Arginase as a target for treatment of myocardial ischemia-reperfusion injury

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Arginase activity and nitric oxide levels in patients with obstructive sleep apnea syndrome

Yüksel, M., Okur, H. K., Pelin, Z., Öğünç, A. V., & Öztürk, L. (2014) · Clinics · doi:10.6061/clinics/2014(04)05 · Cited by 28

Erythropoietin alleviates post-ischemic injury of rat hearts by attenuating nitrosative stress

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Modifying effect of intravenous laser therapy on the protein expression of arginase and epidermal growth factor receptor in type 2 diabetic patients

Kazemikhoo, N., Sarafnejad, A., Ansari, F., & Mehdipour, P. (2016) · Lasers in Medical Science · doi:10.1007/s10103-016-2012-x · Cited by 28

Role of myeloid-derived suppressor cells in tumor recurrence

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Arginase inhibition reduces infarct size via nitric oxide, protein kinase C epsilon and mitochondrial ATP-dependent K+ channels

Tratsiakovich, Y., Gonon, A. T., Krook, A., Yang, J., Shemyakin, A. S., Sjöquist, P.-O. B., & Pernow, J. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.044 · Cited by 29

Interplay Between Metabolic Pathways and Increased Oxidative Stress in Human Red Blood Cells

Spinelli, S., Marino, A., Morabito, R., & Remigante, A. (2024) · Cells · doi:10.3390/cells13232026 · Cited by 27

Beauty and the beast: host microRNA-155 versus SARS-CoV-2

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Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

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Regulation of arginase pathway in response to wall shear stress

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The Role of Arginase and Rho Kinase in Cardioprotection from Remote Ischemic Perconditioning in Non-Diabetic and Diabetic Rat In Vivo

Kiss, A., Tratsiakovich, Y., Gonon, A. T., Fedotovskaya, O. N., Lanner, J. T., Andersson, D. C., Yang, J., & Pernow, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104731 · Cited by 27

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

Bhatta, A., Sangani, R., Kolhe, R., Toque, H., Cain, M., Wong, A., Howie, N., Shinde, R. S., Elsalanty, M., Yao, L., et al. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.12.005 · Cited by 26

A New Perspective on Alzheimer’s Disease as a Brain Expression of a Complex Metabolic Disorder

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Pharmacologic Agents Elevating cAMP Prevent Arginase II Expression and Proliferation of Pulmonary Artery Smooth Muscle Cells

Chen, B., Calvert, A. E., Meng, X., et al. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0015oc · Cited by 26

Role of vascular Kinin B1 and B2 receptors in endothelial nitric oxide metabolism

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Dietary supplementation of tiger nut alters biochemical parameters relevant to erectile function in l -NAME treated rats

Olabiyi, A. A., Carvalho, F. B., Bottari, N. B., Lopes, T. F., da Costa, P., Stefanello, N., Morsch, V. M., Akindahunsi, A. A., Oboh, G., & Schetinger, M. R. C. (2018) · Food Research International · doi:10.1016/j.foodres.2018.04.046 · Cited by 26

Arginase inhibition prevents the development of hypertension and improves insulin resistance in obese rats

Peyton, K. J., Liu, X., Shebib, A. R., Johnson, F. K., Johnson, R. A., & Durante, W. (2018) · Amino Acids · doi:10.1007/s00726-018-2567-x · Cited by 26

Regulation of arginine transport and metabolism by Protein Kinase Cα in endothelial cells: stimulation of CAT2 transporters and arginase activity

Visigalli, R., Barilli, A., Parolari, A., Sala, R., Rotoli, B. M., Bussolati, O., Gazzola, G. C., & Dall’Asta, V. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.04.007 · Cited by 26

Association of Hypertension and Obesity with Risk Factors of Cardiovascular Diseases in Children Aged 6–9 Years Old in the Eastern Cape Province of South Africa

Matjuda, E. N., Engwa, G. A., Letswalo, P. B., Mungamba, M. M., Sewani-Rusike, C. R., & Nkeh-Chungag, B. N. (2020) · Children · doi:10.3390/children7040025 · Cited by 25

Desbalanço redox: NADPH oxidase como um alvo terapêutico no manejo cardiovascular

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Prevalence of pulmonary hypertension in sickle cell anaemia patients of a tertiary hospital in Nigeria

Dosunmu, A. O., Balogun, T. M., Adeyeye, O. O., Daniel, F. A., Akinola, R., Josephine, J., Akinbami, A., Sagoe, A., & Onadeko, B. O. (2014) · Nigerian Medical Journal · doi:10.4103/0300-1652.129661 · Cited by 25

Cellular and physiological upregulation of inducible nitric oxide synthase, arginase, and inducible cyclooxygenase in wound healing

El‐Aleem, S. A. A., Abdelwahab, S. A., AM‐Sherief, H., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28930 · Cited by 25

Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy?

Shosha, E., Fouda, A. Y., Narayanan, S. P., Caldwell, R. W., & Caldwell, R. B. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020425 · Cited by 26

Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress‐Induced Arterial Hypertension

Gilinsky, M. A., Polityko, Y. К., Львович, М. А., Latysheva, T. V., Samson, A. O., Polis, B., & Naumenko, S. E. (2020) · BioMed Research International · doi:10.1155/2020/4935386 · Cited by 24

Impaired Coronary and Renal Vascular Function in Spontaneously Type 2 Diabetic Leptin-Deficient Mice

Westergren, H. U., Grönros, J., Heinonen, S. E., Miliotis, T., Jennbacken, K., Sabirsh, A., Ericsson, A., Jönsson‐Rylander, A., Svedlund, S., & Gan, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130648 · Cited by 25

M2 Macrophages and Phenotypic Modulation of Intestinal Smooth Muscle Cells Characterize Inflammatory Stricture Formation in Rats

Lourenssen, S. R., & Blennerhassett, M. G. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.05.015 · Cited by 24

Preparation of Antibacterial, Arginine-Modified Ag Nanoclusters in the Hydrogel Used for Promoting Diabetic, Infected Wound Healing

Jiang, H., Xu, Q. L., Wang, X., et al. (2023) · ACS Omega · doi:10.1021/acsomega.2c07266 · Cited by 24

Oral Supplementation of Phosphatidylcholine Attenuates the Onset of a Diet-Induced Metabolic Dysfunction–Associated Steatohepatitis in Female C57BL/6J Mice

Sánchez, V., Baumann, A., Brandt, A., Wodak, M. F., Staltner, R., & Bergheim, I. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.01.009 · Cited by 25

L-arginine metabolism in early-onset and late-onset pre-eclamptic pregnancies

Tamás, P., Bódis, J., Sulyok, E., et al. (2013) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2013.803230 · Cited by 24

Nitric oxide and l -arginine metabolism in a devascularized porcine model of acute liver failure

Sharma, V., Have, G. A. M. T., Ytrebø, L. M., Sen, S., Rose, C. F., Dalton, R. N., Turner, C., Revhaug, A., van Eijk, H. M. H., Deutz, N. E. P., et al. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00268.2011 · Cited by 24

Comprehensive metabonomic analysis of heart tissue from isoproterenol‐induced myocardial infarction rat based on reversed‐phase and hydrophilic interaction chromatography coupled to mass spectrometry

Sun, L., Liu, J., Sun, M., et al. (2017) · Journal of Separation Science · doi:10.1002/jssc.201601013 · Cited by 24

Arginase as a Potential Target in the Treatment of Alzheimer’s Disease

Polis, B., & Samson, A. O. (2018) · Advances in Alzheimer s Disease · doi:10.4236/aad.2018.74009 · Cited by 23

Effects of Dietary L-arginine Supplementation from Conception to Post- Weaning in Piglets

Che, D., Adams, S., Zhao, B. X., Qin, G., & Jiang, H. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666190125104959 · Cited by 24

Enteral arginase II provides ornithine for citrulline synthesis

Marini, J. C., Keller, B., Didelija, I. C., Castillo, L., & Lee, B. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00413.2010 · Cited by 23

Arginase inhibition by (−)-Epicatechin reverses endothelial cell aging

Garate‐Carrillo, A., Navarrete-Yañez, V., Ortiz-Vilchis, P., Guevara, G., Castillo, C., Mendoza‐Lorenzo, P., Ceballos, G. M., Ortíz-Flores, M., Nájera, N., Bustamante-Pozo, M. M., et al. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173442 · Cited by 23

Perioperative arginine prevents metastases by accelerating natural killer cell recovery after surgery

Angka, L., de Souza, C. T., Baxter, K. E., Khan, S., Market, M., Martel, A. B., Tai, L., Kennedy, M. A., Bell, J. C., & Auer, R. C. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.05.024 · Cited by 22

Arginase depletes plasma l-arginine and decreases pulmonary vascular reserve during experimental pulmonary embolism

Watts, J. A., Gellar, M. A., Fulkerson, M.-B. K., Das, S. K., & Kline, J. A. (2011) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2011.10.005 · Cited by 23

What's New in the Pathophysiology of Sickle Cell Disease?

Adekile, A. D. (2013) · Medical Principles and Practice · doi:10.1159/000350283 · Cited by 23

The temporal effect of a wild blueberry (Vaccinium angustifolium)-enriched diet on vasomotor tone in the Sprague-Dawley rat

Bo’, C. D., Kristo, A. S., Kalea, A. Z., Ciappellano, S., Riso, P., Porrini, M., & Klimis‐Zacas, D. J. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.05.004 · Cited by 23

Almonds Inhibit Dyslipidemia and Vascular Dysfunction in Rats through Multiple Pathways

Jamshed, H., & Gilani, A. H. (2014) · Journal of Nutrition · doi:10.3945/jn.114.198721 · Cited by 23

Influence of Statin Pretreatment on Initial Neurological Severity and Short-Term Functional Outcome in Acute Ischemic Stroke Patients: The Fukuoka Stroke Registry

Ishikawa, H., Wakisaka, Y., Matsuo, R., Makihara, N., Hata, J., Kuroda, J., Ago, T., Kitayama, J., Nakane, H., Kamouchi, M., et al. (2016) · Cerebrovascular Diseases · doi:10.1159/000447718 · Cited by 23

Carbamoyl Phosphate Synthetase Subunit MoCpa2 Affects Development and Pathogenicity by Modulating Arginine Biosynthesis in Magnaporthe oryzae

Liu, X., Cai, Y., Zhang, X., et al. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02023 · Cited by 23

Thiamine deficiency leads to reduced nitric oxide production and vascular dysfunction in rats

Gioda, C. R., Capettini, L. D. S. A., Cruz, J. S., et al. (2013) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2013.06.010 · Cited by 22

Pathological Features of Enterovirus 71-Associated Brain and Lung Damage in Mice Based on Quantitative Proteomic Analysis

Jin, Y., Li, D., Sun, T., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.663019 · Cited by 22

High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies

Contreras‐Duarte, S., Cantin, C., Farías, M., & Leiva, A. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166216 · Cited by 23

Cerebral Changes Occurring in Arginase and Dimethylarginine Dimethylaminohydrolase (DDAH) in a Rat Model of Sleeping Sickness

Amrouni, D., Meiller, A., Gautier, S. M., Piraud, M., Bouteille, B., Vincendeau, P., Buguet, A., & Cespuglio, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016891 · Cited by 22

Evidence that Nitric Oxide is Involved in the Blood Pressure Lowering Effect of the Peptide AVFQHNCQE in Spontaneously Hypertensive Rats

Mas‐Capdevila, A., Iglesias‐Carres, L., Arola‐Arnal, A., Aragonès, G., Aleixandre, A., Bravo, F. I., & Muguerza, B. (2019) · Nutrients · doi:10.3390/nu11020225 · Cited by 22

L-Arginine and immune modulation: A pharmacological perspective on inflammation and autoimmune disorders

Dimeji, I. Y., Abass, K. S., Audu, N. M., & Adekola, S. A. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177615 · Cited by 26

Grape seed flavanols decrease blood pressure via Sirt-1 and confer a vasoprotective pattern in rats

Pons, Z., Margalef, M., Bravo, F. I., Arola‐Arnal, A., & Muguerza, B. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.03.030 · Cited by 22

Regulation of MAP kinase-mediated endothelial dysfunction in hyperglycemia via arginase I and eNOS dysregulation

Mazrouei, S., Sharifpanah, F., Caldwell, R. W., Franz, M., Shatanawi, A., Muessig, J. M., Fritzenwanger, M., Schulze, P. C., & Jung, C. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.05.004 · Cited by 21

Gastrointestinal dysfunction in diabetic rats relates with a decline in tissue l-arginine content and consequent low levels of nitric oxide

Umathe, S. N., Kochar, N. I., Jain, N. S., et al. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.10.007 · Cited by 21

An Increased Arginase Activity Is Associated with Corpus Cavernosum Impairment Induced by Hypercholesterolemia

Fraga-Silva, R. A., Costa-Fraga, F. P., Faye, Y., Sturny, M., Santos, R. A. S., da Silva, R., & Stergiopulos, N. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12482 · Cited by 20

Unveiling differences between patients with acute coronary syndrome with and without ST elevation through fingerprinting with CE‐MS and HILIC‐MS targeted analysis

Naz, S., Calderón, Á. A., Garcı́a, A., Gallafrio, J. M., Mestre, R. T., González, E. G., de Cabo, C. M., Delgado, M. C. M., Balanza, J. Á. L., Simionato, A. V. C., et al. (2015) · Electrophoresis · doi:10.1002/elps.201500169 · Cited by 20

Characterization of arginase 1 gene polymorphisms in the Algerian population and association with blood pressure

Meroufel, D. N., Dumont, J., Médiène-Benchekor, S., et al. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.03.004 · Cited by 20

Increased arginase levels contribute to impaired perfusion after cardiopulmonary resuscitation

Jung, C., Quitter, F., Lichtenauer, M., Fritzenwanger, M., Pfeil, A., Shemyakin, A. S., Franz, M., Figulla, H. R., Pfeifer, R., & Pernow, J. (2014) · European Journal of Clinical Investigation · doi:10.1111/eci.12330 · Cited by 20

The Endothelium, Part II: EDHF-Mediated Responses "The Classical Pathway"

Félétou, M. (2011) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00032ed1v01y201105isp020 · Cited by 20

Impact of Arginase II on CBF in Experimental Cortical Impact Injury in Mice Using MRI

Bitner, B. R., Brink, D. C., Mathew, L. C., Pautler, R. G., & Robertson, C. S. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.47 · Cited by 20

The role of L-arginine metabolism in neurocritical care patients

Mader, M. M.-D., & Czorlich, P. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.327331 · Cited by 19

L-arginine and glycine supplementation in the repair of the irradiated colonic wall of rats

Picanço, E. D. A., Paulo, F. L., Marques, R. G., Diestel, C. F., Caetano, C. E. R., de Souza, M. V. M., Moscoso, G. M., & Pazos, H. M. F. (2011) · International Journal of Colorectal Disease · doi:10.1007/s00384-011-1154-3 · Cited by 19

l -Arginine supplementation does not improve muscle function during recovery from resistance exercise

de Andrade, W. B., Jacinto, J. L., da Silva, D. K., Roveratti, M. C., Estoche, J. M., Oliveira, D. B., Balvedi, M. C. W., da Silva, R. A., & Aguiar, A. F. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0594 · Cited by 20

Effectiveness of arginase inhibitors against experimentally induced stroke

Barakat, W., Fahmy, A., Askar, M., & Elkannishy, S. (2018) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-018-1489-1 · Cited by 19

Up-regulation of arginase II contributes to pulmonary vascular endothelial cell dysfunction during experimental pulmonary embolism

Watts, J. A., Marchick, M. R., Gellar, M. A., & Kline, J. A. (2011) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2011.01.009 · Cited by 19

Increased expression of arginase I and II in allergic nasal mucosa

Cho, W. S., Kim, T. H., Kim, K. H., et al. (2011) · The Laryngoscope · doi:10.1002/lary.21288 · Cited by 19

The effects of caffeine, caffeic acid, and their combination on acetylcholinesterase, adenosine deaminase and arginase activities linked with brain function

Akomolafe, S. F. (2017) · Journal of Food Biochemistry · doi:10.1111/jfbc.12401 · Cited by 19

Kidney Mass Reduction Leads to l ‐Arginine Metabolism‐Dependent Blood Pressure Increase in Mice

Pillai, S. M., Seebeck, P., Fingerhut, R., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.008025 · Cited by 19

Vascular Arginase Contributes to Arteriolar Endothelial Dysfunction in a Rat Model of Hemorrhagic Shock

Johnson, R. A., Durante, W., Craig, T. A., Peyton, K. J., Myers, J. G., Stewart, R. M., & Johnson, F. K. (2010) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181e771a3 · Cited by 18

Arginase II is a target of miR-17-5p and regulates miR-17-5p expression in human pulmonary artery smooth muscle cells

Jin, Y., Jin, Y., Chen, B., et al. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00266.2013 · Cited by 18

The role of arginase in the microcirculation in cardiovascular disease

Wernly, B., Pernow, J., Kelm, M., & Jung, C. (2019) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-199237 · Cited by 18

Intestinal Transcriptomic and Histologic Profiling Reveals Tissue Repair Mechanisms Underlying Resistance to the Parasite Ceratonova shasta

Barrett, D., Estensoro, I., Sitjà‐Bobadilla, A., & Bartholomew, J. L. (2021) · Pathogens · doi:10.3390/pathogens10091179 · Cited by 17

Increased levels of circulating arginase I in overweight compared to normal weight adolescents

Jung, C., Figulla, H. R., Lichtenauer, M., Franz, M., & Pernow, J. (2013) · Pediatric Diabetes · doi:10.1111/pedi.12054 · Cited by 18

Single- and multiple-dose pharmacokinetics of arginase inhibitor Nω-hydroxy-nor-L-arginine, and its effect on plasma amino acids concentrations in Wistar rats

Havlínová, Z., Hroch, M., Nagy, A., Šišpera, L., Holeček, M., & Chládek, J. (2014) · General Physiology and Biophysics · doi:10.4149/gpb_2013078 · Cited by 19

Sodium nitrite therapy rescues ischemia-induced neovascularization and blood flow recovery in hypertension

Amin, A. H., Choi, S. K., Osman-Elazeik, Y., El-Din, N. K. B., Kevil, C. G., Navar, L. G. B., Kadowitz, P. J., Trebak, M., & Matrougui, K. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1167-y · Cited by 17

Gut permeability is associated with hypertension and measures of obesity but not with Endothelial Dysfunction in South African youth

Ntlahla, E. E., Mfengu, M. M., Engwa, G. A., Nkeh-Chungag, B. N., & Sewani-Rusike, C. R. (2021) · African Health Sciences · doi:10.4314/ahs.v21i3.26 · Cited by 17

Peroxynitrite and Peroxiredoxin in the Pathogenesis of Experimental Amebic Liver Abscess

Pacheco‐Yépez, J., Luna, R. A. J., Gutiérrez-Meza, J. M., Abarca‐Rojano, E., Larsen, B. A., & Campos‐Rodríguez, R. (2014) · BioMed Research International · doi:10.1155/2014/324230 · Cited by 18

The Importance of Nitric Oxide and Arginase in the Pathogenesis of Acute Neuroinflammation: Are Those Contra Players with the Same Direction?

Ljubisavljević, S., Stojanović, I. R., Pavlović, R., & Pavlovic, D. D. (2014) · Neurotoxicity Research · doi:10.1007/s12640-014-9470-3 · Cited by 19

Mechanotransduction in Blood and Lymphatic Vascular Development and Disease

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Cardiovascular Risk Factors and Their Relationship with Vascular Dysfunction in South African Children of African Ancestry

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