Cited by 577Nitric Oxide and Endothelin EffectsAmino Acid Enzymes and MetabolismPolyamine Metabolism and Applications

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ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR FUNCTION

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Durante, William, Johnson, Fruzsina K, Johnson, Robert A·2007·Clinical and Experimental Pharmacology and Physiology

DOI 10.1111/j.1440-1681.2007.04638.xPMC PMC1955221

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Abstract

SUMMARY: Arginase is the focal enzyme of the urea cycle hydrolysing l‐arginine to urea and l‐ornithine. Emerging studies have identified arginase in the vasculature and have implicated this enzyme in the regulation of nitric oxide (NO) synthesis and the development of vascular disease. Arginase inhibits the production of NO via several potential mechanisms, including competition with NO synthase (NOS) for the substrate l‐arginine, uncoupling of NOS resulting in the generation of the NO scavenger, superoxide and peroxynitrite, repression of the translation and stability of inducible NOS protein, inhibition of inducible NOS activity via the generation of urea and by sensitization of NOS to its endogenous inhibitor asymmetric dimethyl‐l‐arginine. Upregulation of arginase inhibits endothelial NOS‐mediated NO synthesis and may contribute to endothelial dysfunction in hypertension, ageing, ischaemia–reperfusion and diabetes. Arginase also redirects the metabolism of l‐arginine to l‐ornithine and the formation of polyamines and l‐proline, which are essential for smooth muscle cell growth and collagen synthesis. Therefore, the induction of arginase may also promote aberrant vessel wall remodelling and neointima formation. Arginase represents a promising novel therapeutic target that may reverse endothelial and smooth muscle cell dysfunction and prevent vascular disease.

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Authors: Durante, W., Johnson, F. K., & Johnson, R. A.
Affiliations: University of Missouri (US)
Tulane University (US)
Corresponding author: Durante, William
ORCID: Durante, William
Johnson, Robert A
Venue: Clinical and Experimental Pharmacology and Physiology
Publisher: Wiley
Published: 2007-04-26
Volume: 34
Issue: 9
Pages: 906-911
ISSN: 0305-1870 (ISSN-L)
1440-1681
DOI: 10.1111/j.1440-1681.2007.04638.x
PMC: PMC1955221
OpenAlex: W2125031388
Cited by: 577
References: 75
Citations by year: 2026: 25 · 2025: 29 · 2024: 21 · 2023: 27 · 2022: 32 · 2021: 45 · 2020: 33 · 2019: 21 · 2018: 25 · 2017: 23 · 2016: 33 · 2015: 25 · 2014: 45 · 2013: 40 · 2012: 29
FWCI: 2.88
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Clinical and Experimental Pharmacology and Physiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL074966, R01HL076187, R01HL059976)
National Center for Research Resources (P20RR017659)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
Keywords: arginase, nitric oxide production, nitric oxide synthase, arginine metabolism, urea cycle, endothelial dysfunction, vascular disease, asymmetric dimethylarginine, inducible nitric oxide synthase, superoxide, peroxynitrite, polyamines, proline, smooth muscle cell proliferation, neointima formation, hypertension, ischaemia-reperfusion, diabetes mellitus, aging
MeSH terms: Animals, Arginase, Arginine, Cardiovascular Diseases, Collagen, Endothelium, Vascular, Homeostasis, Humans, Muscle, Smooth, Vascular, Nitric Oxide, Urea, Reactive Oxygen Species, Cell Proliferation, Nitric Oxide Synthase Type III

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ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR FUNCTION

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