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Gut bacterial translocation is associated with microinflammation in end‐stage renal disease patients
Abstract
Aim: To investigate whether gut bacteria translocation occurs in end‐stage renal disease patients and contributes to microinflammation in end‐stage renal disease (ESRD). Methods: The subjects were divided into two groups: nondialysed ESRD patients (n = 30) and healthy controls (n = 10). Blood samples from all participants were subjected to bacterial 16S ribosomal DNA amplification and DNA pyrosequencing to determine the presence of bacteria, and the alteration of gut microbiomes were examined with the same methods. High‐sensitive C‐reactive protein and interleukin‐6 were detected. Plasma D‐lactate was tested for gut permeability. Results: Bacterial DNAs were detected in the blood of 20% (6/30) of the ESRD patients. All the observed genera in blood (Klebsiella spp, Proteus spp, Escherichia spp, Enterobacter spp, and Pseudomonas spp) were overgrown in the guts of the ESRD patients. Plasma D‐lactate, High‐sensitive C‐reactive protein, and interleukin‐6 levels were significantly higher in patients with bacterial DNA than those without. The control group showed the same results as that of patients without bacterial DNA. Conclusion: Bacterial translocation occurs in ESRD patients and is associated with microinflammation in end stage renal disease.
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“In contrast to Lactobacillus, the population of Enterobacteriaceae of the Proteobacteria phylum is expanded in CKD101,105.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [105]
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Metadata
- Authors
- WANG, F., JIANG, H., SHI, K., REN, Y., ZHANG, P., & CHENG, S.
- Affiliations
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
- Corresponding author
- JIANG, HONGLI
- Venue
- Nephrology
- Publisher
- Wiley
- Published
- 2012-10-29
- Volume
- 17
- Issue
- 8
- Pages
- 733-738
- ISSN
- 1320-5358 (ISSN-L)
- 1440-1797
- OpenAlex
- W2140999961
- Cited by
- 209
- References
- 32
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 17 · 2023: 18 · 2022: 19 · 2021: 22 · 2020: 24 · 2019: 23 · 2018: 16 · 2017: 13 · 2016: 17 · 2015: 14 · 2014: 9 · 2013: 4
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Keywords
- gut bacterial translocation, end-stage renal disease, microinflammation, gut microbiota, D-lactate, intestinal permeability, C-reactive protein, interleukin-6, Klebsiella, Proteus, Escherichia, Enterobacter, Pseudomonas, dialysis patients
- MeSH terms
- Adult, Aged, Bacteria, C-Reactive Protein, Feces, Female, Humans, Inflammation, Kidney Failure, Chronic, Male, Middle Aged, RNA, Ribosomal, 16S, Biomarkers, Interleukin-6, Up-Regulation, Chi-Square Distribution, Case-Control Studies, Sequence Analysis, DNA, Inflammation Mediators, Bacterial Translocation, Lactic Acid, Ribotyping, Gastrointestinal Tract, Metagenome
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